scholarly journals 5-fluorouracil, 4-epidoxorubicin, and mitomycin C (FEM) for advanced gastric carcinoma. A phase II trial

1986 ◽  
Vol 111 (S1) ◽  
pp. S85-S85 ◽  
Author(s):  
W. Queißer ◽  
H. Flechtner ◽  
M. E. Heim ◽  
H. Henß ◽  
H. Arnold ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Mitomycin C ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Gastric Carcinoma

scholarly journals A phase II trial of 5-fluorouracil, doxorubicin, mitomycin C, and leucovorin in advanced gastric carcinoma

Cancer ◽  
1990 ◽  
Vol 65 (11) ◽  
pp. 2442-2445 ◽  
Author(s):  
Susan G. Arbuck ◽  
Yusuf Silk Md ◽  
Harold O. Douglass ◽  
Hector Nava ◽  
Youcef M. Rustum ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Mitomycin C ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Gastric Carcinoma

Phase II trial of trimetrexate for patients with advanced gastric carcinoma

Cancer ◽  
1999 ◽  
Vol 86 (4) ◽  
pp. 572-576 ◽  
Author(s):  
Ramesh K. Ramanathan ◽  
Stuart Lipsitz ◽  
Robert F. Asbury ◽  
Raman Qazi ◽  
Bernard R. Greenberg ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Gastric Carcinoma

Docetaxel, Cisplatin, and Fluorouracil; Docetaxel and Cisplatin; and Epirubicin, Cisplatin, and Fluorouracil As Systemic Treatment for Advanced Gastric Carcinoma: A Randomized Phase II Trial of the Swiss Group for Clinical Cancer Research

2007 ◽  
Vol 25 (22) ◽  
pp. 3217-3223 ◽  
Author(s):  
Arnaud D. Roth ◽  
Nicola Fazio ◽  
Roger Stupp ◽  
Stephen Falk ◽  
Jürg Bernhard ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Performance Status ◽  
Infectious Complications ◽  
Phase Iii ◽  
Survival Times ◽  
Clinical Cancer Research ◽  
Advanced Gastric Carcinoma ◽  
Randomized Phase Ii

PurposeThis randomized phase II trial evaluated two docetaxel-based regimens to see which would be most promising according to overall response rate (ORR) for comparison in a phase III trial with epirubicin-cisplatin-fluorouracil (ECF) as first-line advanced gastric cancer therapy.Patients and MethodsChemotherapy-naïve patients with measurable unresectable and/or metastatic gastric carcinoma, a performance status ≤ 1, and adequate hematologic, hepatic, and renal function randomly received ≤ eight 3-weekly cycles of ECF (epirubicin 50 mg/m2on day 1, cisplatin 60 mg/m2on day 1, and fluorouracil [FU] 200 mg/m2/d on days 1 to 21), TC (docetaxel initially 85 mg/m2on day 1 [later reduced to 75 mg/m2as a result of toxicity] and cisplatin 75 mg/m2on day 1), or TCF (TC plus FU 300 mg/m2/d on days 1 to 14). Study objectives included response (primary), survival, toxicity, and quality of life (QOL).ResultsORR was 25.0% (95% CI, 13% to 41%) for ECF, 18.5% (95% CI, 9% to 34%) for TC, and 36.6% (95% CI, 23% to 53%) for TCF (n = 119). Median overall survival times were 8.3, 11.0, and 10.4 months for ECF, TC, and TCF, respectively. Toxicity was acceptable, with one toxic death (TC arm). Grade 3 or 4 neutropenia occurred in more treatment cycles with docetaxel (TC, 49%; TCF, 57%; ECF, 34%). Global health status/QOL substantially improved with ECF and remained similar to baseline with both docetaxel regimens.ConclusionTime to response and ORR favor TCF over TC for further evaluation, particularly in the neoadjuvant setting. A trend towards increased myelosuppression and infectious complications with TCF versus TC or ECF was observed.

The addition of pravastatin to chemotherapy in advanced gastric carcinoma: A randomised phase II trial

2010 ◽  
Vol 46 (18) ◽  
pp. 3200-3204 ◽  
Author(s):  
Inge R.H.M. Konings ◽  
A. van der Gaast ◽  
Lidemarie J. van der Wijk ◽  
Felix E. de Jongh ◽  
Ferry A.L.M. Eskens ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Gastric Carcinoma

Phase II trial of trimetrexate in untreated advanced gastric carcinoma

1994 ◽  
Vol 12 (2) ◽  
pp. 155-157 ◽  
Author(s):  
Alexander Hantel ◽  
Catherine M. Tangen ◽  
John S. Macdonald ◽  
Stephen P. Richman ◽  
Reginald P. Pugh ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Advanced Gastric Carcinoma
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