Age-dependent expression of high-voltage activated calcium currents during cerebellar granule cell development in situ

1994 ◽  
Vol 429 (1) ◽  
pp. 107-116 ◽  
Author(s):  
Paola Rossi ◽  
Egidio D'Angelo ◽  
Jacopo Magistretti ◽  
Mauro Toselli ◽  
Vanni Taglietti
Keyword(s):  
High Voltage ◽  
Granule Cell ◽  
Cell Development ◽  
Cerebellar Granule Cell ◽  
Calcium Currents ◽  
Cerebellar Granule ◽  
Age Dependent

scholarly journals BDNF-Mediated Cerebellar Granule Cell Development Is Impaired in Mice Null for CaMKK2 or CaMKIV

2009 ◽  
Vol 29 (28) ◽  
pp. 8901-8913 ◽  
Author(s):  
M. Kokubo ◽  
M. Nishio ◽  
T. J. Ribar ◽  
K. A. Anderson ◽  
A. E. West ◽  
...  
Keyword(s):  
Granule Cell ◽  
Cell Development ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule

scholarly journals Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development

2001 ◽  
Vol 154 (6) ◽  
pp. 1259-1274 ◽  
Author(s):  
Takeshi Sakurai ◽  
Marc Lustig ◽  
Joanne Babiarz ◽  
Andrew J.W. Furley ◽  
Steven Tait ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Granule Cell ◽  
Cell Adhesion Molecules ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Cell Development ◽  
Cerebellar Granule Cell ◽  
Granule Cell Layer ◽  
Cerebellar Granule

The structurally related cell adhesion molecules L1 and Nr-CAM have overlapping expression patterns in cerebellar granule cells. Here we analyzed their involvement in granule cell development using mutant mice. Nr-CAM–deficient cerebellar granule cells failed to extend neurites in vitro on contactin, a known ligand for Nr-CAM expressed in the cerebellum, confirming that these mice are functionally null for Nr-CAM. In vivo, Nr-CAM–null cerebella did not exhibit obvious histological defects, although a mild size reduction of several lobes was observed, most notably lobes IV and V in the vermis. Mice deficient for both L1 and Nr-CAM exhibited severe cerebellar folial defects and a reduction in the thickness of the inner granule cell layer. Additionally, anti-L1 antibodies specifically disrupted survival and maintenance of Nr-CAM–deficient granule cells in cerebellar cultures treated with antibodies. The combined results indicate that Nr-CAM and L1 play a role in cerebellar granule cell development, and suggest that closely related molecules in the L1 family have overlapping functions.

Expression of transcription factors and signaling molecules in the cerebellar granule cell development

2019 ◽  
Vol 34 ◽  
pp. 119068 ◽  
Author(s):  
Ryo D. Shiraishi ◽  
Sathoshi Miyashita ◽  
Mariko Yamashita ◽  
Toma Adachi ◽  
Mana M. Shimoda ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Granule Cell ◽  
Cell Development ◽  
Signaling Molecules ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule

scholarly journals Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation

2018 ◽  
Vol 38 (5) ◽  
pp. 1277-1294 ◽  
Author(s):  
Tomoo Owa ◽  
Shinichiro Taya ◽  
Satoshi Miyashita ◽  
Mariko Yamashita ◽  
Toma Adachi ◽  
...  
Keyword(s):  
Granule Cell ◽  
Cell Development ◽  
Bmp Signaling ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule

The Transcription Factor Cux1 in Cerebellar Granule Cell Development and Medulloblastoma Pathogenesis

2014 ◽  
Vol 13 (6) ◽  
pp. 698-712 ◽  
Author(s):  
Sabine Topka ◽  
Alexander Glassmann ◽  
Gunnar Weisheit ◽  
Ulrich Schüller ◽  
Karl Schilling
Keyword(s):  
Transcription Factor ◽  
Granule Cell ◽  
Cell Development ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule
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