The role of insulin-like growth factor-1 (IGF-1) in follicular thyroid cancer cell line CGTH W-1

1995 ◽  
Vol 31 (11) ◽  
pp. 817-821 ◽  
Author(s):  
J. D. Lin ◽  
H. Y. Chang ◽  
Y. S. Ho ◽  
H. F. Weng
1992 ◽  
Vol 28 (11) ◽  
pp. 1904-1909 ◽  
Author(s):  
Noritaka Onoda ◽  
Eiji Ohmura ◽  
Toshio Tsushima ◽  
Yoshito Ohba ◽  
Naoya Emoto ◽  
...  

2003 ◽  
Vol 179 (3) ◽  
pp. 387-394 ◽  
Author(s):  
JW Chang ◽  
KY Yeh ◽  
YC Shen ◽  
JJ Hsieh ◽  
CK Chuang ◽  
...  

An anaplastic thyroid cancer cell line, Thena, was recently established in our laboratory following radical thyroidectomy of a patient with anaplastic thyroid cancer. Microscopically, Thena cells were spindle-shaped or small round cells. Thena cells were reactive with cytokeratin AE1/AE3 antibodies, epithelial membrane antigen, interleukin (IL)-6, epithelial growth factor receptor, transforming growth factor (TGF)-alpha, vascular endothelial growth factor, and vimentin. Thena cells secreted high levels of IL-6, leukemia inhibitor factor (LIF), tumor necrosis factor (TNF)-alpha, and TGF-beta1 in the culture supernatants, as determined by enzyme-linked immunosorbent assay. When subcutaneously injected with Thena cells, athymic nude mice developed tumor masses in the skin within 2 weeks. Furthermore, Thena cells induced cachexia in these tumor-bearing mice. High levels of human IL-6, LIF and TGF-beta1 were detected in the mouse sera. To our knowledge, the Thena cell line is the first thyroid cancer cell line reported to induce cachexia in nude mice. This cachectic animal model is worthy of further study to explore the treatment of thyroid cancer-induced cachexia.


2021 ◽  
Vol 123 (3) ◽  
pp. 151700
Author(s):  
Marjan Ghorbani-Anarkooli ◽  
Sara Dabirian ◽  
Adib Zendedel ◽  
Hasan Moladoust ◽  
Mohammad hadi Bahadori

2002 ◽  
Vol 80 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Kana Ogisawa ◽  
Naoyoshi Onoda ◽  
Tetsuro Ishikawa ◽  
Chiemi Takenaka ◽  
Masaaki Inaba ◽  
...  

2009 ◽  
Vol 50 (8) ◽  
pp. 1364-1370 ◽  
Author(s):  
O. Prante ◽  
S. Maschauer ◽  
V. Fremont ◽  
J. Reinfelder ◽  
R. Stoehr ◽  
...  

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