Mucosal defense against enteric pathogens

1983 ◽  
Vol 50 (3) ◽  
pp. 311-317
Author(s):  
S. C. Sanyal
Pathology ◽  
2001 ◽  
Vol 33 (3) ◽  
pp. 353-358 ◽  
Author(s):  
Christopher J. McIverw ◽  
Grant Hansman ◽  
Peter White ◽  
Jennifer C. Doultree ◽  
Michael Catton ◽  
...  
Keyword(s):  

2020 ◽  
Vol 28 (8) ◽  
pp. 976-981
Author(s):  
Elahe Tajeddin ◽  
Leila Ganji ◽  
Zahra Hasani ◽  
Fahimeh Sadat Ghoalm Mostafaei ◽  
Masoumeh Azimirad

1999 ◽  
Vol 40 (4-5) ◽  
pp. 363-368 ◽  
Author(s):  
C. P. Gerba ◽  
J. A. Thurston ◽  
J. A. Falabi ◽  
P. M. Watt ◽  
M. M. Karpiscak

The enhancement of water quality by artificial wetland systems is increasingly being employed throughout the world. Three wetlands were studied in Tucson, AZ to evaluate their individual performance in the removal of indicator bacteria (coliforms), coliphage, and enteric pathogens (Giardia and Cryptosporidium). A duckweed-covered pond, a multi-species subsurface flow (SSF) and a multi-species surface flow (SF) wetland were studied. Removal of the larger microorganisms, Giardia and Cryptosporidium, was the greatest in the duckweed pond at 98 and 89 percent, respectively. The lowest removal occurred in the SF wetland, 73 percent for Giardia and 58 percent removal for Cryptosporidium. In contrast, the greatest removal of coliphage, total and fecal coliforms occurred in the SSF wetland, 95, 99, and 98 percent respectively, whereas the pond had the lowest removals (40, 62, and 61 percent, respectively). Sedimentation may be the primary removal mechanism within the duckweed pond since the removal was related to size, removal of the largest organisms being the greatest. However, the smaller microorganisms were removed more efficiently in the SSF wetland, which may be related to the large surface area available for adsorption and filtration. This study suggests that in order to achieve the highest treatment level of secondary unchlorinated wastewater, a combination of aquatic ponds and subsurface flow wetlands may be necessary.


2013 ◽  
Vol 11 (4) ◽  
pp. 326-332 ◽  
Author(s):  
Arun Jha ◽  
Beena Uppal ◽  
Sanjim Chadha ◽  
Prabhav Aggarwal ◽  
Roumi Ghosh ◽  
...  

Science ◽  
2018 ◽  
Vol 362 (6418) ◽  
pp. eaat9076 ◽  
Author(s):  
Yael Litvak ◽  
Mariana X. Byndloss ◽  
Andreas J. Bäumler

An imbalance in the colonic microbiota might underlie many human diseases, but the mechanisms that maintain homeostasis remain elusive. Recent insights suggest that colonocyte metabolism functions as a control switch, mediating a shift between homeostatic and dysbiotic communities. During homeostasis, colonocyte metabolism is directed toward oxidative phosphorylation, resulting in high epithelial oxygen consumption. The consequent epithelial hypoxia helps to maintain a microbial community dominated by obligate anaerobic bacteria, which provide benefit by converting fiber into fermentation products absorbed by the host. Conditions that alter the metabolism of the colonic epithelium increase epithelial oxygenation, thereby driving an expansion of facultative anaerobic bacteria, a hallmark of dysbiosis in the colon. Enteric pathogens subvert colonocyte metabolism to escape niche protection conferred by the gut microbiota. The reverse strategy, a metabolic reprogramming to restore colonocyte hypoxia, represents a promising new therapeutic approach for rebalancing the colonic microbiota in a broad spectrum of human diseases.


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