scholarly journals Acute and chronic toxicity studies on partially purified hypoglycemic preparation from water extract of bark ofFicus bengalensis

2002 ◽  
Vol 17 (1) ◽  
pp. 58-63 ◽  
Author(s):  
S. Gupta ◽  
R. Shukla ◽  
K. M. Prabhu ◽  
S. Aggrawal ◽  
U. Rusia ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Water Extract ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity

Acute and chronic toxicity studies on Polygonum glabrum in experimental animals

2020 ◽  
Vol 3 (1) ◽  
pp. 7-10
Author(s):  
Saravanakumar A ◽  
Gandhimathi R
Keyword(s):  
Chronic Toxicity ◽  
Clinical Stage ◽  
Herbal Medicines ◽  
Plant Roots ◽  
Root Extract ◽  
Experimental Animals ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
Diuretic Agents

Polygonum glabrum is being used in traditional and folklore medicine to treat pneumonia and jaundice. Plant roots are used in ayurvedic preparations to treat fever and colic. The leaves are used as diuretic agents and process vermifuge action. Plant decoction is also used in the treatment of Rheumatism. Besides having many uses and folklore claims, herbal medicines are to be thoroughly investigated for their toxicity also. Therefore this work is being carried out to examine the toxicity of the drug and established dose is safe to use in the clinical stage. The current research studied the acute and chronic toxicity of Polygonum glabrum root extract in rats. It is proved that there was no change in any parameter tested both in acute and chronic toxicity, which means the extract is safe and non-toxic at the dose of 2g/kg also.

scholarly journals Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats

2017 ◽  
Vol 4 (2) ◽  
pp. 45-56
Author(s):  
Piao-Piao Zhang ◽  
Xiao-Dan Yan ◽  
Xiao-Yu Fan ◽  
Ya-Hao Ling ◽  
Chao Li ◽  
...  
Keyword(s):  
Chronic Toxicity ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity

THE EFFECT OF LYNESTRENOL) ON ANIMAL REPRODUCTION

1962 ◽  
Vol 41 (3) ◽  
pp. 351-370 ◽  
Author(s):  
G. A. Overbeek ◽  
Z. Madjerek ◽  
J. de Visser
Keyword(s):  
Inhibitory Action ◽  
Chronic Toxicity ◽  
List Type ◽  
Low Doses ◽  
Animal Reproduction ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
General Toxicity ◽  
Oral Activity

ABSTRACT Lynestrenol is a potent oral pregestagen. The oral activities in the Clauberg and Corner & Allen tests are of the same order as that of subcutaneously administered progesterone. No effect was found in the tests for deciduomagenic activity in the mouse and for the maintenance of pregnancy in the rat. Lynestrenol has a marked inhibitory action on ovulation in the rat. This effect can be enhanced by low doses of oestrogen, which themselves are inactive in this respect. The main cause of this effect seems to be an inhibition of the development of the follicles. Lynestrenol is a weak oestrogen with an activity of about 1–2% of that of ethinyloestradiol. Its effects on fertilized ova in the rat are in agreement with what could be expected from its oestrogenic activity. There is little or no effect on nidation. Lynestrenol is a weak androgen, the oral activity in the rat amounting to 1/3–1/4 of that of methyltestosterone. 5. Acute and chronic toxicity studies demonstrate the absence of any general toxicity.

Acute and chronic toxicity studies with monochlorobenzene in rainbow trout

1982 ◽  
Vol 2 (3) ◽  
pp. 127-142 ◽  
Author(s):  
George M. Dalich ◽  
Robert E. Larson ◽  
William H. Gingerich
Keyword(s):  
Rainbow Trout ◽  
Chronic Toxicity ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity
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