Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice

2009 ◽  
Vol 19 (3) ◽  
pp. 275-282 ◽  
Author(s):  
S. C. Udem ◽  
O. Obidoa ◽  
I. U. Asuzu
Keyword(s):  
Chronic Toxicity ◽  
Stem Bark ◽  
Bark Extract ◽  
Toxicity Studies ◽  
Acute And Chronic Toxicity ◽  
Stem Bark Extract

Antibacterial Activity and Sub-chronic Toxicity Studies of Vitellaria paradoxa Stem Bark Extract

2012 ◽  
Vol 7 (6) ◽  
pp. 298-304 ◽  
Author(s):  
A.A. Ayankunle ◽  
O.T. Kolawole ◽  
A.A. Adesokan ◽  
M.O. Akiibinu
Keyword(s):  
Antibacterial Activity ◽  
Chronic Toxicity ◽  
Stem Bark ◽  
Bark Extract ◽  
Vitellaria Paradoxa ◽  
Toxicity Studies ◽  
Stem Bark Extract

Acute and sub-chronic oral toxicity studies of an aqueous stem bark extract of Pterocarpus soyauxii Taub (Papilionaceae) in rodents

2011 ◽  
Vol 133 (2) ◽  
pp. 329-335 ◽  
Author(s):  
M.C. Tchamadeu ◽  
P.D.D. Dzeufiet ◽  
P. Nana ◽  
C.C. Kouambou Nouga ◽  
F. Ngueguim Tsofack ◽  
...  
Keyword(s):  
Stem Bark ◽  
Bark Extract ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Stem Bark Extract

Subchronic toxicity studies of aqueous leaf and stem bark extract of Irvingia gabonensis in male albino wistar rats

2017 ◽  
Vol 26 (3) ◽  
pp. 553-559 ◽  
Author(s):  
Chukwunonso K. Ezeasor ◽  
Chigozie Chukwuma ◽  
Samuel O. Ekere ◽  
Patrick Abah
Keyword(s):  
Wistar Rats ◽  
Stem Bark ◽  
Bark Extract ◽  
Subchronic Toxicity ◽  
Toxicity Studies ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague–Dawley rats

2013 ◽  
Vol 55 ◽  
pp. 617-626 ◽  
Author(s):  
Seo-Ho Shin ◽  
Kyo-Hwan Koo ◽  
Jin-Sook Bae ◽  
Seung-Bum Cha ◽  
In-Soo Kang ◽  
...  
Keyword(s):  
Oral Dose ◽  
Stem Bark ◽  
Bark Extract ◽  
Sprague Dawley ◽  
Toxicity Studies ◽  
Rhus Verniciflua ◽  
Sprague Dawley Rats ◽  
Stem Bark Extract

scholarly journals Acute and sub-acute toxicity studies of Methanol stem bark extract of Cadaba farinosa (Forssk) in wistar rats.

2021 ◽  
Vol 6 (3) ◽  
pp. 81-88
Author(s):  
M.L. Umaru ◽  
G.N. Uyaiabasi
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Stem Bark ◽  
Ion Concentration ◽  
Bark Extract ◽  
Long Term Conditions ◽  
Follicular Hyperplasia ◽  
Toxicity Studies ◽  
Stem Bark Extract

The study focused on evaluating the toxicity profile of the methanol stem bark extract of Cadaba farinose (Forssk), considering possibilities of adverse effects arising from continual use of herbal plants especially in the management of long-term conditions. Cadaba farinosa is a slender shrub plant widely used traditionally in the treatment of various diseases such as diabetes mellitus, inflammations, rheumatic pains and various infections including skin and intestine both in Africa and India. The acute toxicity study and sub-acute toxicity studies were carried out in Wistar rats using Lorkes Method (1983) and the OECD Guidelines 425. For the sub-acute toxicity studies, twenty rats weighing between 120 and 170g were randomly grouped into 4 groups of 5 rats each. Group 1 (control) received 10ml/kg of distilled water and the others received doses of 40, 200 and 1000mg/kg p.o of extract for 28 days. The acute toxicity revealed no mortality or behavioural signs of toxicity in both phases up to 5000mg/kg. The haematological indices revealed a significant (p<0.05) increase in the WBC count, MCV and PLT of the groups that received 1000mg/kg of the extract after treatment for 28 days. The liver function test showed a significant increase (p<0.05) in AST and ALT. Renal indices showed a significant decrease in creatinine and a significant increase (p<0.05) in plasma Na+, K+ and Cl- ion concentration across the groups. Histopathological section of the spleen revealed follicular hyperplasia. The results suggest that the plant could be slightly toxic to the liver and the spleen on long-term use.

scholarly journals Acute and Sub-chronic Toxicity Studies on Methanol Stem Bark Extract of Frankincense Tree (Boswellia dalzielii) and Leaves Extract of Kenaf (Hibiscus cannabinus)

2021 ◽  
pp. 33-38
Author(s):  
S. Salihu ◽  
C. A. Otitolaiye ◽  
M. U. Hizbullah
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Chronic Toxicity ◽  
Stem Bark ◽  
Toxicity Study ◽  
Bark Extract ◽  
Albino Rats ◽  
Liver And Kidney ◽  
Stem Bark Extract ◽  
Oral Acute Toxicity

Aim: Frankincense tree (Boswellia dalzielii) and Kenaf (H. cannabinus) are plants abundantly found in north-western Nigeria. These plants are very popular among the locals as potent sources of ethno medicine. The present study investigates the oral acute toxicity potentials of methanolic stem bark extract of frankincense tree and Kenaf leaves, as well as sub-chronic toxicity potentials of the plants extracts on the kidney and liver of Albino rats. Study Design: Laboratory-experimental design was used for this study. Place and Duration of Study: This study was carried out between September 2019 and November 2019 at Biochemistry laboratory, Sokoto State University, Sokoto, Nigeria. Methodology: For the oral acute toxicity study, the revised “Up and Down” test (Limit Dose Test) was used to determine the LD50 of the extracts. For sub-chronic toxicity study, twenty albino rats were used for each plant, and were divided into four groups of five animals each. Group I (control), Group II (received 200 mg extract/kg body weight), Group III (received 400 mg extract/kg body weight) and Group IV (received 800 mg extract/kg body weight). All administrations were given orally for 28 days. Liver and kidney markers were determined using standard methods. Result: The oral acute toxicity test of the plant extracts at 3000 mg/kg body weight showed no mortality for 24 hours and subsequent 14days of administration. LD50 for both plants is therefore greater than 3000 mg/kg. The result shows no significant differences (p > 0.05) on liver and kidney function biomarkers investigated when Group II, III and IV are compared with control. Conclusion: This suggests that Frankincense stem bark and kenaf leaves extracts may be safe in rats at doses less than or equal 3000 mg/kg.

scholarly journals Sub-chronic toxicity study of ethanol stem-bark extract of Blighia sapida (Sapindaceae) in wistar rats

Heliyon ◽  
2020 ◽  
Vol 6 (2) ◽  
pp. e02801 ◽  
Author(s):  
M.B. Adekola ◽  
J.O. Areola ◽  
N.O. Omisore ◽  
F.T. Asaolu ◽  
S.G. Ogunleye ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Chronic Toxicity ◽  
Stem Bark ◽  
Toxicity Study ◽  
Bark Extract ◽  
Stem Bark Extract ◽  
Blighia Sapida
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