The role of polymorphonuclear leukocytes in delayed hypersensitivity skin reactions: Suppressive effects of anti-polymorphonuclear leukocyte serum

1981 ◽  
Vol 37 (1) ◽  
pp. 191-198
Author(s):  
Takeshi Kambara ◽  
Tatsuomi Yasaka ◽  
Tadashi Nakamura
Keyword(s):  
Polymorphonuclear Leukocyte ◽  
Polymorphonuclear Leukocytes ◽  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Hypersensitivity Skin

scholarly journals THE ROLE OF THYMUS AND BONE MARROW CELLS IN DELAYED HYPERSENSITIVITY

1971 ◽  
Vol 134 (5) ◽  
pp. 1144-1154 ◽  
Author(s):  
David G. Tubergen ◽  
Joseph D. Feldman
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Specific Antigen ◽  
Delayed Hypersensitivity ◽  
Cell Type ◽  
Skin Reactions ◽  
Lymph Node Cells ◽  
Thymus Cells ◽  
Marrow Cells

Adoptive transfer experiments were performed to define the immunological role of thymus and bone marrow cells in the induction of delayed hypersensitivity (DH). The results indicated the following, (a) Bone marrow from immune donors contained cells capable of being stimulated by antigen to initiate the expression of DH. (b) Bone marrow from nonimmune or tolerant donors contained cells that were needed to complete the expression of DH after the infusion of immune lymph node cells. (c) Normal bone marrow and thymus cells cooperated in the irradiated recipient to induce the most vigorous skin reactions to specific antigen; these reactions were seen only when the recipients were stimulated by antigen. Either cell type alone was ineffective. (d) In the presence of tolerant bone marrow cells, thymus cells from immune donors gave a more vigorous response than did thymus cells from normal or tolerant donors. (e) There was suggestive evidence that thymus cells were the source of trigger elements that initiated DH. (f) Antigen in the irradiated recipient was necessary to induce DH after infusion of bone marrow cells alone, or bone marrow and thymus cells together.

ATAXIA TELANGIECTASIA WITH CEREBELLAR TUMOR

PEDIATRICS ◽  
1966 ◽  
Vol 37 (5) ◽  
pp. 776-786
Author(s):  
J. Shuster ◽  
Z. Hart ◽  
C. W. Stimson ◽  
A. J. Brough ◽  
M. D. Poulik
Keyword(s):  
Experimental Evidence ◽  
Ataxia Telangiectasia ◽  
Antibody Responses ◽  
Thymus Gland ◽  
Delayed Hypersensitivity ◽  
Cerebellar Tumor ◽  
Skin Grafts ◽  
Skin Reactions ◽  
Hypersensitivity Skin ◽  
Circulating Antibody

Two patients with ataxia telangiectasia were studied. There is absence of γA immunoglobulin, poor delayed hypersensitivity skin reactions, and abnormal rejection of skin grafts. The susceptibility to sinopulmonary infections is probably related to the abnormal cellular and circulating antibody responses which these patients demonstrate. Experimental evidence indicates that the fundamental immunologic defect in this disease lies in thymus gland. The etiology of the neurologic abnormalities is unknown. The first instance of a cerebellar tumor to develop in this syndrome is reported.

Delayed Hypersensitivity Skin Reactions in the Elderly

1982 ◽  
Vol 30 (7) ◽  
pp. 447-448 ◽  
Author(s):  
HOWARD LICHTENSTEIN ◽  
SARAH F. SCHWARTZBORD ◽  
W. LAWRENCE DREW ◽  
LAWRENCE Z. FEIGENBAUM ◽  
HAROLD BROWNSTEIN
Keyword(s):  
The Elderly ◽  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Hypersensitivity Skin

scholarly journals The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.

1977 ◽  
Vol 145 (5) ◽  
pp. 1288-1298 ◽  
Author(s):  
P Chao ◽  
L Francis ◽  
E Atkins
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Polymorphonuclear Leukocytes ◽  
Delayed Hypersensitivity ◽  
Endogenous Pyrogen ◽  
Phagocytic Cells ◽  
Relationship Of ◽  
The Relationship

Guinea pig periotoneal exudate (PE) cells incubated overnight in vitro with heat-killed Staphylococci released an endogenous pyrogen (EP) that could be assayed by intravenous injection in rabbits. The febrile responses were linearly related to the dosage of EP over an eightfold range. PE cells derived from guinea pigs with delayed hypersensitivity (DH) to bovine gamma globulin (BGG), also released EP when incubated with antigen in vitro. This reaction was specific and did not occur withe PE cells from normal or complete Freund's adjuvant-sensitized guinea pigs. Studies indicated that monos and/or polymorphonuclear leukocytes rather than lymphocytes were the source of EP. However, when incubated with BGG and sufficient dosages of BGG-sensitized lymphocytes, normal PE cells released EP over a 42 h period. These results suggest that antigen stimulates specifically sensitized lymphocytes to release an agent (perhaps a lymphokine) that activates phagocytic cells to release EP. This model offers unique advantages for investigating in vitro the role of the lymphocyte in antigen-induced fever in DH as well as the relationship of this lymphocyte-induced activity to other known biologic activities mediated by antigen stimulated lymphocytes.

Diagnosis of granulomatous starch peritonitis by delayed hypersensitivity skin reactions

1982 ◽  
Vol 69 (4) ◽  
pp. 197-199 ◽  
Author(s):  
J. B. F. Grant ◽  
J. D. Davies ◽  
H. J. Espiner ◽  
W. K. Eltringham
Keyword(s):  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Hypersensitivity Skin

scholarly journals Hapten-specific delayed hypersensitivity to epsilon-2,4-dinitrophenyl-L-lysine-Ficoll in guinea pigs immunized with 2,4-dinitrophenyl-keyhole limpet hemocyanin.

1977 ◽  
Vol 145 (5) ◽  
pp. 1101-1114 ◽  
Author(s):  
P R McMaster ◽  
J D Owens ◽  
H F Dvorak ◽  
R Weichbrod ◽  
R Asofsky
Keyword(s):  
Skin Reaction ◽  
Guinea Pigs ◽  
Polymorphonuclear Leukocytes ◽  
Keyhole Limpet Hemocyanin ◽  
Active Immunization ◽  
Delayed Hypersensitivity ◽  
Delayed Reaction ◽  
Skin Reactions ◽  
Pale Pink ◽  
Erythematous Skin

After active immunization with 2,4-dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH), 2,4-dinitropheynl-L-lysine (DNPL)-Ficoll may elicit indurated, erythematous skin reactions lasting 24-72 h. Histological sections of these reactions, examined by microscope techniques, showed they contained polymorphonuclear leukocytes and perivascularly situated lymphocytes and macrophages, but had very few basophils. Consequently, the reaction was interpreted as having an immediate component and a component typical of delayed hypersensitivity; this indicated that the delayed reaction could be specific for the DNP hapten. Although this delayed type of skin reaction was not transferred to recipients with anti-DNP-KLH serum, one pool of that serum did sensitize guinea pigs so that they could respond with a different skin reaction after challenge with DNPL-Ficoll. This reaction was soft, pale pink, and lasted for 24 h. Histologically, it contained only a few polymorphonuclear leukocytes. It differed from the delayed reaction in actively immunized animals in that it lacked induration, and was devoid of lymphocytes and macrophages.

INHIBITION OF DELAYED HYPERSENSITIVITY SKIN REACTIONS IN PATIENTS ON METHOXYPSORALEN PHOTOCHEMOTHERAPY

The Lancet ◽  
1980 ◽  
Vol 316 (8200) ◽  
pp. 922 ◽  
Author(s):  
Celia Moss ◽  
Peter Friedmann ◽  
Sam Shuster
Keyword(s):  
Delayed Hypersensitivity ◽  
Skin Reactions ◽  
Hypersensitivity Skin

Neutrophil Function during Cyclic Chemotherapy for Cancer Disease

1983 ◽  
Vol 69 (5) ◽  
pp. 409-415 ◽  
Author(s):  
Sebastiano Garelli ◽  
Giuseppe Schieppati ◽  
Luciano Banfi ◽  
Pierluigi Meroni
Keyword(s):  
Neutrophil Function ◽  
Delayed Hypersensitivity ◽  
Skin Tests ◽  
Cancer Disease ◽  
Skin Reactions ◽  
Leukocyte Mobilization ◽  
Tumor Dissemination ◽  
Dye Reduction ◽  
Hypersensitivity Skin ◽  
Granulocyte Function

A study of some aspects of granulocyte function was carried out before, during, and after cyclic chemotherapy in 9 patients surgically treated for carcinoma and in 6 patients with very advanced and inoperable cancer. In most patients, total leukocyte mobilization, Candida-stimulated nitroblue tetrazolium dye reduction, and phagocytosis increased after chemotherapy. Furthermore, delayed hypersensitivity skin reactions to PPD and above all to Varidase increased in the same cases. A significant correlation between accumulation of polymorphonuclear leukocytes into skin chambers and skin tests was found in both groups of patients (p < 0.001). In some instances, fluctuations in the levels of circulating immune complexes without a distinct correlation between these complexes and granulocyte function were found. The data support the hypothesis that depressed granulocyte function may contribute to an increased susceptibility to infections and may be considered an additional factor that favors tumor dissemination. Chemotherapy seems to restore polymorphonuclear function and delayed hypersensitivity skin reactions.

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