Effect of arterial administration of a high molecular weight anti-tumor agent, styrene maleic acid neocarzinostatin, for multiple small liver cancer—A pilot study

1997 ◽  
Vol 32 (4) ◽  
pp. 513-520 ◽  
Author(s):  
Kenji Ikeda ◽  
Satoshi Saitoh ◽  
Yoshiyuki Suzuki ◽  
Akihito Tsubota ◽  
Isao Koida ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pilot Study ◽  
Liver Cancer ◽  
High Molecular Weight ◽  
Maleic Acid ◽  
Small Liver Cancer ◽  
Styrene Maleic Acid Neocarzinostatin ◽  
Tumor Agent

Effect of arterial administration of a high-molecular weight antitumor agent, styrene maleic acid neocarzinostatin, in embolization-resistant liver cancer

1999 ◽  
Vol 4 (3) ◽  
pp. 148-155
Author(s):  
K. Ikeda ◽  
Satoshi Saitoh ◽  
Yoshiyuki Suzuki ◽  
Akihito Tsubota ◽  
Masahiro Kobayashi ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Liver Cancer ◽  
High Molecular Weight ◽  
Maleic Acid ◽  
Antitumor Agent ◽  
Styrene Maleic Acid Neocarzinostatin

scholarly journals Effects of Delayed Sample Processing on Determination of Total and High Molecular Weight (HMW) Adiponectin in Serum and Plasma: A Pilot Study

2016 ◽  
Vol 8 (3) ◽  
pp. 19
Author(s):  
Choaping Ng ◽  
Felicity J Rose ◽  
Sahar Keshvari ◽  
Marina M Reeves ◽  
Goce Dimeski ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pilot Study ◽  
High Molecular Weight ◽  
Accurate Determination ◽  
Mean Difference ◽  
Serum Samples ◽  
Blood Samples ◽  
Hmw Adiponectin ◽  
Total Adiponectin

<p>Adiponectin is a beneficial adipocyte-secreted hormone, which circulates in a variety of multimeric forms termed low and high molecular weight (LMW/HMW). Effectiveness of clinical therapeutic trials which target adiponectin rely on accurate determination of circulating total and HMW adiponectin levels but the accuracy may be influenced by variations in sample handling processes. The aim of this pilot study was to investigate the effects of delayed processing of blood samples on the concentration of total and HMW adiponectin.</p><p>Materials and Methods: Fasting blood samples were collected for analysis of total and HMW adiponectin concentrations in EDTA plasma and serum from eight healthy participants.  Samples were centrifuged post 15 min storage at 4<sup>o</sup>C as the comparative ‘ideal’ method or after up to 72 h of refrigerated storage or 6 h at room temperature. Total and HMW adiponectin concentrations were measured by ELISA.</p><p>Results: Under ideal handling conditions measurements of total and HMW adiponectin concentrations were significantly higher in serum than in plasma (mean difference: -1.3 µg/mL [95% CI: -1.6, -1.0], p&lt;0.001; and, -0.6 µg/mL [95% CI: -0.7, -0.5], p&lt;0.001, respectively).  Storage of blood samples at 4<sup>o</sup>C for 72 h resulted in significant reductions in concentration of total adiponectin in serum (mean difference: -1.4 µg/mL [95% CI: -2.0, -0.8], p=0.001) and HMW adiponectin in plasma (mean difference: -0.6 µg/mL [95%CI: -0.9, -0.2], p=0.007), compared with ideal conditions.  Further analysis of serum samples showed a significant decrease in total adiponectin concentration after 6 h storage at 4<sup>o</sup>C (mean difference: -1.4 µg/mL [95% CI: -2.0, -0.8], p=0.001) compared with ideal conditions.</p><p>Conclusions: Delayed processing of samples may have differential effects on the concentration of total and HMW adiponectin in serum or plasma. Larger studies are warranted for clinical intervention trials.</p>

ChemInform Abstract: High-Molecular Weight Styrene-Maleic Acid Copolymers as Corrosion Inhibitors for Aluminum Pigments.

ChemInform ◽  
2010 ◽  
Vol 26 (37) ◽  
pp. no-no
Author(s):  
B. MUELLER ◽  
T. SCHMELICH
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Maleic Acid ◽  
Corrosion Inhibitors

High-molecular weight styrene-maleic acid copolymers as corrosion inhibitors for aluminium pigments

1995 ◽  
Vol 37 (6) ◽  
pp. 877-883 ◽  
Author(s):  
B. Müller ◽  
T. Schmelich
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Maleic Acid ◽  
Corrosion Inhibitors

Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study

2021 ◽  
Author(s):  
Michael Baboudjian ◽  
Marc Fourmarier ◽  
Christophe Clement ◽  
Arnaud Cherasse ◽  
Jean-Pierre Graziana ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pilot Study ◽  
High Molecular Weight ◽  
Sodium Hyaluronate ◽  
Intravesical Instillation ◽  
Prospective Pilot Study ◽  
Radiation Induced

Two new approaches based on dynamic carboxyl–hydroxyl or hydroxyl–carboxyl transformation for high molecular weight poly(butylene maleate)

2020 ◽  
Vol 11 (36) ◽  
pp. 5884-5892
Author(s):  
Tong Chen ◽  
Sunan Tian ◽  
Zhining Xie ◽  
Zhao-Xia Guo ◽  
Jun Xu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Maleic Acid ◽  
New Approaches ◽  
Green Approach ◽  
Huge Challenge ◽  
High Molecular Weight Poly

Synthesis of high molecular weight maleic acid-based polyesters via a green approach is of great significance but also a huge challenge.

Pilot study on the effects of high molecular weight sodium hyaluronate in the treatment of chronic pharyngitis

2015 ◽  
Vol 28 (4) ◽  
pp. 532-538 ◽  
Author(s):  
CA Leone ◽  
A Armone Caruso ◽  
V Allocca ◽  
E Barra ◽  
R Leone
Keyword(s):  
Molecular Weight ◽  
Pilot Study ◽  
High Molecular Weight ◽  
Sodium Hyaluronate

Studies on Chemically Modified Fibrinogen

1976 ◽  
Vol 35 (02) ◽  
pp. 324-333 ◽  
Author(s):  
M Kloczewiak ◽  
Z Wegrzynowicz ◽  
F.R Matthias ◽  
D.L Heene ◽  
Maria Zajdel
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Functional Properties ◽  
Maleic Acid ◽  
Acid Anhydride ◽  
Polymerization Process ◽  
Chemically Modified ◽  
Fibrinogen Molecule

SummaryTreatment of fibrinogen with maleic acid anhydride renders fibrinogen unclottable depending on the degree of modification of the molecule. According to radioactive studies the release of fibrinopeptides by thrombin or reptilase is undisturbed. The incoagulability is due to inhibition of the polymerization process of fibrinmonomers derived from modified fibrinogen, mainly caused by the increase of electronegative charges upon the fibrinogen molecule. According to discelectrophoretic analysis modified fibrinogen fails to produce fragments D and E following plasmic digestion, however, may be degraded to high molecular weight products. Modified fibrinogen reveals some similarities to abnormal fibrinogens in congenital dysfibrinogenemia with regard to its functional properties.

scholarly journals Oral Intake of a Liquid High-Molecular-Weight Hyaluronan Associated with Relief of Chronic Pain and Reduced Use of Pain Medication: Results of a Randomized, Placebo-Controlled Double-Blind Pilot Study

2015 ◽  
Vol 18 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Gitte S. Jensen ◽  
Victoria L. Attridge ◽  
Miki R. Lenninger ◽  
Kathleen F. Benson
Keyword(s):  
Molecular Weight ◽  
Chronic Pain ◽  
Pilot Study ◽  
High Molecular Weight ◽  
Oral Intake ◽  
Pain Medication ◽  
Double Blind
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