Inhibitory effect of papaverine on the contraction induced by transmural stimulation in the isolated mouse vas deferens

1992 ◽  
Vol 15 (2) ◽  
pp. 134-137 ◽  
Author(s):  
Eun-Hee Park ◽  
Yoon Sun Song
Keyword(s):  
Vas Deferens ◽  
Inhibitory Effect ◽  
Mouse Vas Deferens ◽  
Transmural Stimulation

Antagonism by the tetramine disulfide benextramine of the inhibitory effects mediated by prejunctional alpha2-adrenoceptors and by postjunctional histamine H2 receptors in the mouse vas deferens

1984 ◽  
Vol 62 (9) ◽  
pp. 1147-1151 ◽  
Author(s):  
M. M. Vohra ◽  
A. Chaudhry
Keyword(s):  
Vas Deferens ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Mouse Vas Deferens ◽  
Alpha Adrenoceptors ◽  
Twitch Response ◽  
H2 Receptors ◽  
A Site ◽  
Non Equilibrium

The actions of benextramine, which blocks postjunctional alpha-adrenoceptors noncompetitively and irreversibly (non-equilibrium type) on prejunctional alpha-adrenoceptors (alpha2) and postjunctional histamine H2 receptors, were studied in the mouse vas deferens, using clonidine and histamine, respectively, as the agonists. Both agonists caused a dose-related inhibition of the electrically evoked twitch responses, an inhibition that their respective antagonists (yohimbine or phentolamine, and cimetidine) antagonized competitively. Benextramine, however, antagonized the agonists' inhibitory effect noncompetitively. At the concentrations used, while clonidine or yohimbine and phentolamine protected the prejunctional alpha-adrenoceptors (alpha2) against the benextramine noncompetitive blockade, histamine or cimetidine failed to protect the histamine H2 receptor against benextramine blockade. Therefore, although benextramine acts prejunctionally to block the alpha2-adrenoceptors in the mouse vas deferens either by interacting directly with the same site as clonidine or yohimbine and phentolamine, or allosterically with a site close to it, it does not appear to act irreversibly, either directly or allosterically, with the same site as histamine or cimetidine. The mechanism by which benextramine blocks the histamine-induced inhibition of the electrically evoked twitch response in the mouse vas deferens remains to be established.

Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens

1997 ◽  
Vol 772 (1-2) ◽  
pp. 102-106 ◽  
Author(s):  
Ge Zhang ◽  
Thomas F Murray ◽  
David K Grandy
Keyword(s):  
Guinea Pig ◽  
Vas Deferens ◽  
Inhibitory Effect ◽  
Orphanin Fq ◽  
Guinea Pig Ileum ◽  
Mouse Vas Deferens

scholarly journals A non-opioid mechanism in the inhibitory effect of ginseng saponins on electrically evoked contractions of guinea-pig ileum and mouse vas deferens.

1988 ◽  
Vol 11 (6) ◽  
pp. 453-458 ◽  
Author(s):  
Joe WATANABE ◽  
KiWan OH ◽  
HackSeang KIM ◽  
Masakatsu TAKAHASHI ◽  
Hiroshi KANETO
Keyword(s):  
Guinea Pig ◽  
Vas Deferens ◽  
Inhibitory Effect ◽  
Guinea Pig Ileum ◽  
Mouse Vas Deferens ◽  
Electrically Evoked Contractions ◽  
Evoked Contractions

scholarly journals EFFECT OF ENKEPHALIN AND SUBSTANCE P ON SYMPATHETIC NERVE TRANSMISSION IN MOUSE VAS DEFERENS

1978 ◽  
Vol 28 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Tomio SEGAWA ◽  
Hiroko MURAKAMI ◽  
Hiroshi OGAWA ◽  
Haruaki YAJIMA
Keyword(s):  
Substance P ◽  
Sympathetic Nerve ◽  
Vas Deferens ◽  
Mouse Vas Deferens

Opioid agonist affinity in the guinea-pig ileum and mouse vas deferens

1990 ◽  
Vol 179 (1-2) ◽  
pp. 129-139 ◽  
Author(s):  
Frank Porreca ◽  
Diane LoPresti ◽  
Susan J. Ward
Keyword(s):  
Guinea Pig ◽  
Vas Deferens ◽  
Guinea Pig Ileum ◽  
Opioid Agonist ◽  
Mouse Vas Deferens ◽  
Agonist Affinity

scholarly journals Bretylium or 6-OHDA-resistant, action potential-evoked Ca2+ transients in varicosities of the mouse vas deferens

2002 ◽  
Vol 135 (8) ◽  
pp. 1845-1850 ◽  
Author(s):  
V Margaret Jackson ◽  
Tom C Cunnane
Keyword(s):  
Action Potential ◽  
Vas Deferens ◽  
Mouse Vas Deferens
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