Зміни варіабельності серцевого ритму щурів при модуляції аміназином центральної норадренергічної нейротрансмісії протягом тривалого стресу

It’s established that under the prolonged stress there were changes of geometric and spectral indices of the rats’ heart rate variability (HRV), manifestations of which depended on duration of stressful factors acting and represented the stress reaction development from the stage of anxiety to the exhaustion phase. Application of chlorpromazine at the beginning and against the background of stress blocked the central alpha adrenoceptors and contributed to renewal of the most HRV indices into the limits of control values at the end of experiment. The results of research show that the modulation of functional state of central noradrenergic system plays a great role in the changes of HRV during prolonged stress.