Follow-up study of thyroid function in polytransfused thalassemic patients

AbstractThe non-thyroidal illness syndrome (NTIS) is considered a transient and completely reversible phenomenon, but it has been shown that it may last for several days postoperatively after coronary artery bypass grafting (CABG) surgery. This study was undertaken to assess thyroid function 6 months after uncomplicated CABG. The thyroid profile was evaluated in 40 consecutive patients undergoing CABG preoperatively, at 0, 12, 48, and 120h postoperatively, and at 6-month follow-up. Triiodothyronine (T

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Growth and Thyroid Function in Children With In Utero Exposure to Dioxin: A 5-Year Follow-Up Study

Pediatric Research ◽

10.1203/pdr.0b013e3181c8f04b ◽

2010 ◽

Vol 67 (2) ◽

pp. 205-210 ◽

Cited By ~ 26

Author(s):

Pen-Hua Su ◽

Jia-Yuh Chen ◽

Jein-Wen Chen ◽

Shu-Li Wang

Keyword(s):

Thyroid Function ◽

In Utero ◽

In Utero Exposure ◽

Follow Up Study

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Short-term Follow-up Study of Thyroid Function in Polytransfused Thalassemic Patients

Endocrine Disorders in Thalassemia ◽

10.1007/978-88-470-2183-9_3 ◽

1995 ◽

pp. 11-17

Author(s):

S. Andò ◽

M. Maggiolini ◽

G. De Luca ◽

M. Bria ◽

D. Sisci ◽

...

Keyword(s):

Thyroid Function ◽

Short Term ◽

Follow Up Study

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Ten-Year Follow-Up Study of Thyroid Function in Euthyroid Patients with Simple Goiter or Hashimoto's Thyroiditis.

Internal Medicine ◽

10.2169/internalmedicine.34.371 ◽

1995 ◽

Vol 34 (5) ◽

pp. 371-375 ◽

Cited By ~ 3

Author(s):

Akira SATO ◽

Toru AIZAWA ◽

Yoichi KOIZUMI ◽

Ichiro KOMIYA ◽

Kazuo ICHIKAWA ◽

...

Keyword(s):

Thyroid Function ◽

Hashimoto’S Thyroiditis ◽

Hashimoto's Thyroiditis ◽

Follow Up Study

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Early Follow-up of Atypical Thyroiditis Induced by SARS-CoV-2

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.124 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A61-A61

Author(s):

Ilaria Muller ◽

Daniele Cannavaro ◽

Davide Dazzi ◽

Giovanna Mantovani ◽

Virgilio Longari ◽

...

Keyword(s):

Thyroid Function ◽

Post Infection ◽

Thyroid Dysfunction ◽

Subacute Thyroiditis ◽

Full Blood Count ◽

Control Group ◽

Thyroid Peroxidase ◽

Follow Up Study ◽

Serum Tsh

Abstract Background: In Spring 2020 the severe acute respiratory syndrome coronavirus 2 pandemic disease (Covid-19) badly affected Northern Italy. We have described for the first time the occurrence of thyrotoxicosis due to atypical subacute thyroiditis in 15% of patients hospitalised for Covid-19 pneumonia, compared with only 1% among patients hospitalised in the same wards during Spring 2019, thus before the Covid-19 pandemic. The whole group of Covid-19 patients also had median serum TSH concentrations significantly lower compared with the control group. The atypical thyroiditis induced by Covid-19 is not associated with neck pain, affects more men than women and especially those severely ill, thus coexists with non-thyroidal illness syndrome. Subacute thyroiditis is classically followed by subsequent occurrence of permanent thyroid dysfunction and autoimmunity, thus we have started a systematic follow-up program of these patients. Methods: Longitudinal follow-up study of survived Covid-19 patients without previous known history of thyroid disorders and/or medications, assessing serum thyroid function and autoantibodies, C reactive protein (CRP), full blood count (FBC) and thyroid ultrasound (US) every 3 months. Patients showing baseline (at hospitalisation for Covid-19) thyroid dysfunction and/or focal hypoechoic areas suggestive for subacute thyroiditis at US performed 3 months post-infection, also underwent thyroid 99mTc or I123uptake. Results: To date, 53 patients have been included in the follow-up study. At 3 months post-infection, all of them presented with increased median (IQR) serum TSH concentrations compared with baseline: 1.3 (0.9–2.0) mIU/L versus 0.9 (0.5–1.8) mIU/L (p=0.0001). Similarly, serum concentrations of free-thyroxine, free-triiodothyronine, CRP and FBC had normalised compared with baseline. All patients had negative autoantibodies to TSH receptor; autoantibodies to thyroglobulin and to thyroid peroxidase were positive in 6/53 (11%) and 5/53 (9%) of patients, respectively. The thyroid US showed the presence of focal hypoechoic areas of thyroiditis in 16/51 (32%) patients, with thyroid uptake normal in 6/16 (37%), focally reduced in 8/16 (50%) and diffusely reduced in 2/16 (12%). Conclusions: At 3 months after Covid-19 disease all patients had a normalised thyroid function, however imaging findings suggestive for subacute thyroiditis were still present in about one third of cases. The thyroid dysfunction induced by Covid-19 seems not mediated by autoimmunity. It is important to continue to follow these patients since they might develop thyroid dysfunction during the following months.

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Serum thyroglobulin in hospitalized chronic geriatric patients: its relationship to age, non-thyroidal illness, goitre and thyroid dysfunction in a follow-up study

Acta Endocrinologica ◽

10.1530/eje.0.1310462 ◽

1994 ◽

Vol 131 (5) ◽

pp. 462-466 ◽

Cited By ~ 1

Author(s):

István Szabolcs ◽

Wolfdieter Bernard ◽

Franz A Horster

Keyword(s):

Thyroid Function ◽

Predictive Value ◽

Thyroid Dysfunction ◽

Geriatric Patients ◽

Clinical State ◽

Serum Thyroglobulin ◽

Follow Up Study ◽

Healthy Control ◽

Clear Differentiation

Szabolcs I, Bernard W, Horster FA. Serum thyroglobulin in hospitalized chronic geriatric patients: its relationship to age, non-thyroidal illness, goitre and thyroid dysfunction in a follow-up study. Eur J Endocrinol 1994;131:462–6. ISSN 0804–4643 The objectives were to determine whether the serum thyroglobulin (TG) level is influenced by age or by non-thyroidal illness (NTI) of the aged, to investigate the constancy of the TG level after 1- and 2-month intervals and to investigate if the TG level could help to differentiate whether a subnormal thyrotrophin (TSH) level in a geriatric patient is caused by autonomous thyroid function, by age or by NTI. Two-hundred and twenty-six non-selected, chronic hospitalized patients over 60 years old and 82 healthy adults (20–40 years) participated in the study, and TSH, thyroxine, free thyroxine, triiodothyronine and TG were estimated. In 122 euthyroid geriatric patients with normal TSH the mean TG was normal (12.18 μg/l), but elevated (> 45 μg/l) TG values occurred more often than in healthy control persons (15/122 vs 3/82; χ(1)2 = 4.54, p = 0.03). The severity of the clinical state of the euthyroid patients had no influence on the TG values. If TG was measured after 1 and/or 2 months, in only 3/123 non-selected geriatric patients was there a fluctuation between the normal and abnormal range (versus fluctuation of the corresponding TSH values in 19/123 cases; χ(1)2 = 12.78, p = 0.0012). In 28 patients with subnormal TSH, a normal TG value had a predictive value of 0.6 to exclude autonomous thyroid function. Age and NTI of the geriatric patients have no significant influence on their mean TG level but high TG levels occur more often, even in euthyroid patients. The predictive value of TG is not sufficiently high to allow a clear differentiation of whether a subnormal TSH is caused by autonomous thyroid function or by the age process or by NTI. Nevertheless, the advantage of TG estimation to be more constant than TSH could be of benefit in screening studies. I Szabolcs, HIETE I. Bel., Budapest, PO Box 112, 1389, Hungary

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Weight Gain and Serum TSH Increase within the Reference Range after Hemithyroidectomy Indicate Lowered Thyroid Function

Journal of Thyroid Research ◽

10.1155/2014/892573 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Tina Toft Kristensen ◽

Jacob Larsen ◽

Palle Lyngsie Pedersen ◽

Anne-Dorthe Feldthusen ◽

Christina Ellervik ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Thyroid Function ◽

Reference Range ◽

Matched Control ◽

Follow Up Study ◽

Median Serum ◽

Laboratory Reference ◽

Serum Tsh

Background. Weight gain is frequently reported after hemithyroidectomy but the significance is recently discussed. Therefore, the aim of the study was to examine changes in body weight of hemithyroidectomized patients and to evaluate if TSH increase within the reference range could be related to weight gain.Methods. In a controlled follow-up study, two years after hemithyroidectomy for benign euthyroid goiter, postoperative TSH and body weight of 28 patients were compared to preoperative values and further compared to the results in 47 matched control persons, after a comparable follow-up period.Results. Two years after hemithyroidectomy, median serum TSH was increased over preoperative levels (1.23 versus 2.08 mIU/L,P<0.01) and patients had gained weight (75.0 versus 77.3 kg,P=0.02). Matched healthy controls had unchanged median serum TSH (1.70 versus 1.60 mIU/L,P=0.13) and weight (69.3 versus 69.3 kg,P=0.71). Patients on thyroxin treatment did not gain weight. TSH increase was significantly correlated with weight gain (r=0.43,P<0.01).Conclusion. Two years after hemithyroidectomy for benign euthyroid goiter, thyroid function is lowered within the laboratory reference range. Weight gain of patients who are biochemically euthyroid after hemithyroidectomy may be a clinical manifestation of a permanently decreased metabolic rate.

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