Accumulation of thallium-201 in medullary thyroid cancer with negative serum calcitonin and carcinoembryonic antigens: A case report

1993 ◽  
Vol 7 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Mitsuru Koizumi ◽  
Tsutomu Watari ◽  
Kaoru Hirabayashi
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Medullary Thyroid Cancer ◽  
Thallium 201 ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Carcinoembryonic Antigens

scholarly journals SUN-LB82 Coexistence of Medullary Thyroid Cancer With Graves Disease: A Case Report

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Ogochukwu Okoli ◽  
Christine A Resta
Keyword(s):  
Systematic Review ◽  
Thyroid Cancer ◽  
Case Report ◽  
Thyroid Gland ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Cancer ◽  
Graves Disease ◽  
Serum Calcitonin ◽  
Medullary Thyroid

Abstract A 59 year old woman presented with enlarged thyroid, weight loss, and hot flushes. She had previously been treated for a thyroid problem in 2013 but was lost to follow up. On exam, she had a diffusely enlarged thyroid gland, without distinct nodule. She had brisk DTR’s and mild tremor. Lab results confirmed hyperthyroidism:TSH <0.01 mIU/L (0.27 to 4.2) FT4 2.4 ng/dL (0.9 to 1.8) FT3 7.95 pg/mL (1.8 to 4.6). TSI was 307 % (<140%). Thyroid ultrasound showed a few sub-centimeter nodules, and 2 clinically significant nodules on the right--1.5 x 1.2 x 1.4 cm, cystic with calcifications; and 1.3 x 0.7 x 1.2 cm hypoechoic. I-123 thyroid uptake/scan showed 61% uptake and 2 right sided cold nodules. FNA biopsy showed medullary thyroid carcinoma (MTC) with staining positive for calcitonin and negative for thyroglobulin. CT thyroid showed no adenopathy. Serum calcitonin was 71 pg/mL (<5), and CEA was elevated 5.4 ng/mL (<2.5). Work up was negative for pheochromocytoma and hyperparathyroidism.After pretreatment with methimazole, she underwent total thyroidectomy with bilateral TE groove dissection. Surgical pathology confirmed MTC pT1b pN1a. She was started on levothyroxine therapy post operatively. Discussion There are multiple reports of thyroid carcinoma (papillary and follicular) in Graves disease, but rarely MTC.1 A recent systematic review reports only 21 total cases of MTC in patients with hyperthyroidism, of whom 15 had Graves disease.2 MTC is derived from C-cells from the thyroid gland rather than from follicular cells. TSI, therefore, should not influence development or growth of MTC. Coexistence of the two conditions is likely coincidental rather than causative. ConclusionThyroid nodules in patients with Graves should be worked up as there is a possibility of co-existing thyroid carcinoma. This patient had hyperthyroidism with cold nodules on nuclear scan corresponding to sonographic nodules. Based on these results, she had biopsy leading to diagnosis of MTC. Follow up surgery lead to diagnosis of MTC at earlier stage and provided treatment for both conditions. References1. Staniforth, J. U. etal (2016). Thyroid carcinoma in Graves’ disease: a meta-analysis. International Journal of Surgery, 27, 118-125. 2. Sapalidis, K. etal (2019). A Rare Coexistence of Medullary Thyroid Cancer with Graves Disease: A Case Report and Systematic Review of the Literature. The American journal of case reports, 20, 1398

Medullary thyroid cancer and pseudocirrhosis: case report and literature review

2012 ◽  
Vol 19 (1) ◽  
Author(s):  
B. L. Harry ◽  
M.L. Smith ◽  
J.R. Burton Jr ◽  
A. Dasari ◽  
S.G. Eckhardt ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Literature Review ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

scholarly journals Surgical approach to medullary thyroid cancer

2007 ◽  
Vol 51 (5) ◽  
pp. 818-824 ◽  
Author(s):  
Catharina Ihre Lundgren ◽  
Leigh Delbridg ◽  
Diana Learoyd ◽  
Bruce Robinson
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Medullary Thyroid Cancer ◽  
Prophylactic Surgery ◽  
Surgical Removal ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Central Lymph Node Dissection ◽  
Familial Form ◽  
Men 2A

Medullary thyroid cancer (MTC) compromises 3-5% of all thyroid cancers and arises from parafollicular or calcitonin-producing C cells. It may be sporadic (75% of cases), or may occur as a manifestation of either the hereditary syndrome Multiple Endocrine Neoplasia type 2 (MEN 2A or MEN 2B) (25% of cases), or rarely as an isolated familial syndrome (FMTC). Complete surgical resection comprising in most cases total thyroidectomy with central lymph node dissection at an early stage of the disease is the only potential cure for MTC. The familial form of the disease, MEN-2A occupies a unique place in surgical history, having been the first disease where surgical removal of an affected organ was undertaken before the development of malignancy, solely on the basis of genetic testing. Total thyroidectomy prior to the development of invasive cancer completely avoids an otherwise lethal malignancy. Timing of prophylactic surgery is based on models that utilise genotype-phenotype correlations, which have now been stratified into three risk groups based on the specific codon involved. MTC should be followed with postoperative serial serum calcitonin levels to survey for persistent or recurrent disease as indicated by detectable levels. The challenge however, if calcitonin levels are increased, is to find the source of its production. The first localisation technique recommended would be ultrasound of the neck, since there is a high frequency of local recurrence and cervical node metastasis, followed by a total body CT scan and bone scintigraphy.

Selpercatinib as an alternative therapy to Lenvatinib for metastatic medullary thyroid cancer. A case report.

2021 ◽  
Author(s):  
Pascual Cristina Contreras ◽  
Mendez Cristina Montalban ◽  
Tirado Antonio Moreno ◽  
Zhao Montero Benítez Maria ◽  
González Lázaro Paloma ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Medullary Thyroid Cancer ◽  
Alternative Therapy ◽  
Medullary Thyroid

Abstract #1003222: Case Report: Medullary Thyroid Cancer as Part of the MEN2B Syndrome in an 8-year-old Male Patient

2021 ◽  
Vol 27 (6) ◽  
pp. S164-S165
Author(s):  
Maria P. Sarmiento ◽  
Judith S. Garcia ◽  
Susana gomez ◽  
Pilar Pereira ◽  
Nora Zuluaga ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Male Patient ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

Serum Calcitonin May Falsely Estimate Tumor Burden in Chronic Hypercalcemia: A Case of Prostatic and Multiple Bone Metastases from Medullary Thyroid Cancer

Thyroid ◽  
2014 ◽  
Vol 24 (3) ◽  
pp. 599-603 ◽  
Author(s):  
Hee Kyung Kim ◽  
Woo Kyun Bae ◽  
Yoo Duk Choi ◽  
Hyun Jeong Shim ◽  
Jee Hee Yoon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Bone Metastases ◽  
Medullary Thyroid Cancer ◽  
Tumor Burden ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Multiple Bone Metastases
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