scholarly journals Postoperative biochemical remission of serum calcitonin is the best predictive factor for recurrence-free survival of medullary thyroid cancer: a large-scale retrospective analysis over 30 years

2015 ◽  
Vol 84 (4) ◽  
pp. 587-597 ◽  
Author(s):  
Kyong Yeun Jung ◽  
Seok-Mo Kim ◽  
Won Sang Yoo ◽  
Bup-Woo Kim ◽  
Yong Sang Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Retrospective Analysis ◽  
Predictive Factor ◽  
Large Scale ◽  
Medullary Thyroid Cancer ◽  
Recurrence Free Survival ◽  
Serum Calcitonin ◽  
Free Survival ◽  
Medullary Thyroid ◽  
Biochemical Remission

scholarly journals Metastatic Lymph Node Ratio for Predicting Recurrence in Medullary Thyroid Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5842
Author(s):  
Jinyoung Kim ◽  
Jun Park ◽  
Hyunju Park ◽  
Min Sun Choi ◽  
Hye Won Jang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Medullary Thyroid Cancer ◽  
Lymph Node Ratio ◽  
Serum Calcitonin ◽  
Free Survival ◽  
Medullary Thyroid ◽  
Node Ratio ◽  
Postoperative Serum

The lymph node ratio (LNR) has been investigated as a prognostic factor in many different types of cancers, including differentiated thyroid cancer; however, reports regarding medullary thyroid cancer (MTC) are limited. Therefore, this study aims to evaluate LNR as a risk factor for structural recurrence in patients with MTC. Medical records of patients treated for MTC in a single tertiary center between 1995 and 2017 were retrospectively reviewed. LNR is defined as the number of metastatic lymph nodes or lymph node metastases (LNM) divided by the number of retrieved lymph nodes or lymph node yield (LNY). In the survival analysis, recurrence-free survival was defined as the time from the date of total thyroidectomy to recurrence or last follow-up. To identify risk factors influencing structural recurrence, univariable and multivariable Cox proportional hazard models were used. A total of 132 patients were enrolled. The mean age of study participants was 49.7 years, and 86 patients (65%) were women. Structural recurrence was identified in 39 patients at the end of the study period, and the median follow-up period was 8.7 years. In univariable analyses, gross extra thyroidal extension, N stage, postoperative serum calcitonin and carcinoembryonic antigen (CEA) levels, and LNR were significant (p < 0.05) predictors of structural recurrence. In multivariable analysis, postoperative serum calcitonin, postoperative serum CEA, and LNR were identified as a predictor of disease-free survival (p < 0.05). LNR can potentially predict structural recurrence as a quantitative evaluation tool for lymph node metastasis in patients with MTC.

scholarly journals Carcinoembryonic antigen should be concurrently checked with calcitonin to identify distant metastases in medullary thyroid cancer

2020 ◽  
Vol 7 (1) ◽  
pp. IJE27
Author(s):  
Rui Zheng-Pywell ◽  
Anish Jacob Cherian ◽  
Macie Enman ◽  
Herbert Chen ◽  
Deepak Abraham
Keyword(s):  
Thyroid Cancer ◽  
Carcinoembryonic Antigen ◽  
Retrospective Analysis ◽  
Metastatic Disease ◽  
Medullary Thyroid Cancer ◽  
Distant Metastases ◽  
Single Institution ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Additional Imaging

Aim: This study investigates if serum calcitonin or carcinoembryonic antigen (CEA) levels can differentiate between locoregional and metastatic medullary thyroid cancer. Methods: A single institution retrospective analysis was performed on 88 patients with medullary thyroid cancer between 2008 and 2014. Results: In M0disease, calcitonin (p < 0.001) and CEA (p = 0.003) significantly decreased postoperatively. Not only was the correlation significant between calcitonin and CEA preoperatively (r = 0.72; p < 0.001) and postoperatively (r = 0.68; p < 0.001), calcitonin could extrapolate CEA levels (p < 0.001). These findings were statistically insignificant in metastatic disease. Conclusion: Independently, calcitonin and CEA fail to differentiate between locoregional and metastatic disease. Both are essential for prognostication: loss of concordance is suspicious for metastatic disease. Hence, discordant CEA and calcitonin levels should be an indication to pursue additional imaging.

Medullary Thyroid Cancer: A Retrospective Analysis of a Cohort Treated at a Single Tertiary Care Center Between 1970 and 2005

Thyroid ◽  
2007 ◽  
Vol 17 (6) ◽  
pp. 549-556 ◽  
Author(s):  
Simona Grozinsky-Glasberg ◽  
Carlos A. Benbassat ◽  
Gloria Tsvetov ◽  
Rafael Feinmesser ◽  
Hava Peretz ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Retrospective Analysis ◽  
Medullary Thyroid Cancer ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Medullary Thyroid

scholarly journals Surgical approach to medullary thyroid cancer

2007 ◽  
Vol 51 (5) ◽  
pp. 818-824 ◽  
Author(s):  
Catharina Ihre Lundgren ◽  
Leigh Delbridg ◽  
Diana Learoyd ◽  
Bruce Robinson
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Medullary Thyroid Cancer ◽  
Prophylactic Surgery ◽  
Surgical Removal ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Central Lymph Node Dissection ◽  
Familial Form ◽  
Men 2A

Medullary thyroid cancer (MTC) compromises 3-5% of all thyroid cancers and arises from parafollicular or calcitonin-producing C cells. It may be sporadic (75% of cases), or may occur as a manifestation of either the hereditary syndrome Multiple Endocrine Neoplasia type 2 (MEN 2A or MEN 2B) (25% of cases), or rarely as an isolated familial syndrome (FMTC). Complete surgical resection comprising in most cases total thyroidectomy with central lymph node dissection at an early stage of the disease is the only potential cure for MTC. The familial form of the disease, MEN-2A occupies a unique place in surgical history, having been the first disease where surgical removal of an affected organ was undertaken before the development of malignancy, solely on the basis of genetic testing. Total thyroidectomy prior to the development of invasive cancer completely avoids an otherwise lethal malignancy. Timing of prophylactic surgery is based on models that utilise genotype-phenotype correlations, which have now been stratified into three risk groups based on the specific codon involved. MTC should be followed with postoperative serial serum calcitonin levels to survey for persistent or recurrent disease as indicated by detectable levels. The challenge however, if calcitonin levels are increased, is to find the source of its production. The first localisation technique recommended would be ultrasound of the neck, since there is a high frequency of local recurrence and cervical node metastasis, followed by a total body CT scan and bone scintigraphy.

scholarly journals Hereditary Medullary Thyroid Cancer: Age-Appropriate Thyroidectomy Improves Disease-Free Survival

2012 ◽  
Vol 20 (5) ◽  
pp. 1451-1455 ◽  
Author(s):  
Kevin Shepet ◽  
Amal Alhefdhi ◽  
Ngan Lai ◽  
Haggi Mazeh ◽  
Rebecca Sippel ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Disease Free Survival ◽  
Free Survival ◽  
Medullary Thyroid ◽  
Hereditary Medullary Thyroid Cancer ◽  
Age Appropriate ◽  
Disease Free

Serum Calcitonin May Falsely Estimate Tumor Burden in Chronic Hypercalcemia: A Case of Prostatic and Multiple Bone Metastases from Medullary Thyroid Cancer

Thyroid ◽  
2014 ◽  
Vol 24 (3) ◽  
pp. 599-603 ◽  
Author(s):  
Hee Kyung Kim ◽  
Woo Kyun Bae ◽  
Yoo Duk Choi ◽  
Hyun Jeong Shim ◽  
Jee Hee Yoon ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Bone Metastases ◽  
Medullary Thyroid Cancer ◽  
Tumor Burden ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Multiple Bone Metastases

scholarly journals Diagnostics of medullary thyroid cancer and the strategy of its management in the absence of biochemical remission

2011 ◽  
Vol 57 (6) ◽  
pp. 45-51
Author(s):  
D O Gazizova ◽  
D G Bel'tsevich ◽  
A N Tiul'pakov ◽  
O V Simakina ◽  
T V Soldatova
Keyword(s):  
Thyroid Cancer ◽  
Early Diagnosis ◽  
Successful Treatment ◽  
Medullary Thyroid Cancer ◽  
Diagnostic Techniques ◽  
Term Treatment ◽  
Medullary Thyroid ◽  
Long Term Treatment ◽  
Biochemical Remission

Early diagnosis greatly facilitates successful treatment of medullary thyroid cancer. The present paper is designed to report the results of analysis of the studies carried out with the use of various diagnostic techniques and the data obtained during the long-term treatment of the patients with this pathology in the absence of biochemical remission.

Sign in / Sign up

Export Citation Format

Share Document