p53 protein accumulation and p53 gene mutation in colorectal cancer

2000 ◽  
Vol 6 (4) ◽  
pp. 275-279 ◽  
Author(s):  
Anna Nasierowska-Guttmejer ◽  
Lech Trzeciak ◽  
Marek P. Nowacki ◽  
Jerzy Ostrowski
Keyword(s):  
Colorectal Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
Protein Accumulation ◽  
P53 Gene Mutation

scholarly journals p53 protein accumulation and p53 gene mutation in esophageal carcinoma

Cancer ◽  
1997 ◽  
Vol 79 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Guido Coggi ◽  
Silvano Bosari ◽  
Massimo Roncalli ◽  
Daniela Graziani ◽  
Paola Bossi ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
Protein Accumulation ◽  
P53 Gene Mutation

p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation

1995 ◽  
Vol 108 (4) ◽  
pp. 1176-1182 ◽  
Author(s):  
Jean-Christophe Bourdon ◽  
Antonia D'Errico ◽  
Patrizia Paterlini ◽  
Walter Grigioni ◽  
Evelyne May ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
Protein Accumulation ◽  
P53 Gene Mutation

Infrequent p53 gene mutation but UV gradient-like p53 protein positivity in keloids

2012 ◽  
Vol 21 (4) ◽  
pp. 277-280 ◽  
Author(s):  
Ellen Heitzer ◽  
Hannes Seidl ◽  
Isabella Bambach ◽  
Ulrike Schmidbauer ◽  
Lorenzo Cerroni ◽  
...  
Keyword(s):  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
P53 Gene Mutation

Accumulation of p53 Protein as an Indicator for p53 Gene Mutation in Breast Cancer

1993 ◽  
Vol 2 (1) ◽  
pp. 36-41 ◽  
Author(s):  
D. Lohmann ◽  
Ch. Ruhri ◽  
M. Schmitt ◽  
H. Graeff ◽  
H. Hofler
Keyword(s):  
Breast Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
P53 Gene Mutation

p53 gene mutation, tumor p53 protein overexpression, and serum p53 autoantibody generation in patients with breast cancer

2000 ◽  
Vol 33 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Katerina Angelopoulou ◽  
He Yu ◽  
Bhupinder Bharaj ◽  
Maurizia Giai ◽  
Eleftherios P Diamandis
Keyword(s):  
Breast Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
Protein Overexpression ◽  
P53 Gene Mutation ◽  
Serum P53

P53 protein over-expression but not p53 gene mutation is a poor prognostic marker and a predictive marker for survival benefit from adjuvant chemotherapy in non-small cell lung cancer (NSCLC) in the JBR.10 Trial

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7577-7577 ◽  
Author(s):  
M. S. Tsao ◽  
S. Aviel-Ronen ◽  
K. Ding ◽  
D. Lau ◽  
N. Liu ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Gene Mutation ◽  
Prognostic Marker ◽  
P53 Protein ◽  
P53 Gene ◽  
Predictive Marker ◽  
Phase Iii ◽  
Wild Type ◽  
P53 Gene Mutation ◽  
Over Expression

7577 Background: JBR.10, a phase III inter-group trial randomized 482 patients with resected stage IB & II NSCLC to receive 4 cycles of adjuvant cisplatin + vinorelbine or observation alone. Chemotherapy patients had an overall survival (OS) benefit (Hazard Ratio [HR] 0.69, p=0.04). P53 has important regulatory roles in cell cycle progression, apoptosis, gene transcription and DNA repair. We evaluated the prognostic and predictive value of p53 in JBR.10. Methods: P53 protein expression was evaluated by immunohistochemistry (IHC) on tissue micro-arrays (282 available blocks). We used the DO7 antibody, and defined ≥15% nuclear staining as the cutoff for over- expression. Mutations in exons 5–9 were determined by denaturing high performance liquid chromatography (446 available samples), followed by sequencing of aberrant PCR products. Results: Successful assays: p53 mutation, 403/446 patients; p53 IHC, 254/282 patients. P53 gene mutations were found in 126/403 (31%) patients. In the observation arm, mutations were not prognostic of poorer survival (HR = 1.18, 95% CI 0.77–1.81; p= 0.45). Adjuvant chemotherapy effect was not significantly different in p53 mutated and wild type patients (interaction p = 0.66), the estimated HR was 0.68 (95% CI 0.46–1, p=0.047) for patients with wild type p53, and 0.79 (95% CI 0.47–1.33, p=0.37) for mutated patients. P53 protein over-expression was found in 133/254 (52%) patients. Patients with over-expression in the observation arm had a higher risk of death than patients with low expression (HR 1.89, 95% CI 1.07–3.34, p=0.03). However, the adjuvant chemotherapy effect was significantly better in p53 over-expressing patients (interaction p= 0.018), with an estimated HR of 0.53 (95% C.I. 0.31–0.90, p=0.03) for p53 over-expressing patients, and 1.40 (95% C.I. 0.78–2.52, p=0.26) for low expressing patients. Conclusions: P53 protein overexpression but not p53 gene mutation is both a significant prognostic marker of poorer survival in the JBR 10 population and a significant predictive marker for the benefit of adjuvant chemotherapy. [Table: see text]

Accumulation of p53 Protein as an Indicator for p53 Gene Mutation in Breast Cancer

1993 ◽  
Vol 2 (1) ◽  
pp. 36-41
Author(s):  
D. Lohmann ◽  
Ch. Ruhri ◽  
M. Schmitt ◽  
H. Graeff ◽  
H. H??fler
Keyword(s):  
Breast Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
P53 Gene Mutation

scholarly journals Correlations between p53-protein accumulation, serum antibodies and gene mutation in colorectal cancer

1999 ◽  
Vol 81 (5) ◽  
pp. 712-718 ◽  
Author(s):  
Pascal Hammel ◽  
Karen Leroy-Viard ◽  
Marie-Th�r�se Chaumette ◽  
Jacqueline Villaudy ◽  
Marie-Claude Falzone ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Mutation ◽  
P53 Protein ◽  
Protein Accumulation ◽  
Serum Antibodies

A Correlative Study of p53 Protein Alteration and p53 Gene Mutation in Glioblastoma Multiforme

1993 ◽  
Vol 3 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Elizabeth W. Newcomb ◽  
William J. Madonia ◽  
Sobha Pisharody ◽  
Frederick F. Lang ◽  
Maxim Koslow ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Gene Mutation ◽  
P53 Protein ◽  
P53 Gene ◽  
P53 Gene Mutation ◽  
Correlative Study
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