The Role of Rapid Antigen Testing for Influenza in the Era of Molecular Diagnostics

2010 ◽  
Vol 14 (4) ◽  
pp. 205-214 ◽  
Author(s):  
Suzanne E. Dale
Keyword(s):  
Molecular Diagnostics ◽  
Antigen Testing

scholarly journals Role of Pathologist as an Educator in Lifestyle Medicine in Era of Molecular Diagnostics

2018 ◽  
Vol 150 (suppl_1) ◽  
pp. S85-S86
Author(s):  
Ritcha Saxena ◽  
Ananya Saxena ◽  
Mithilesh Chandra ◽  
Ritwik Saxena
Keyword(s):  
Molecular Diagnostics ◽  
Lifestyle Medicine

scholarly journals The State of Cell Blocks and Ancillary Testing: Past, Present, and Future

2016 ◽  
Vol 140 (12) ◽  
pp. 1318-1322 ◽  
Author(s):  
Anjali Saqi
Keyword(s):  
Molecular Diagnostics ◽  
Significant Role ◽  
The State ◽  
Cell Block ◽  
Block Method ◽  
Alternative Techniques

Cell blocks are an integral part of cytology, but their utility is recognized probably more now than ever before, largely owing to the significant role they play in ancillary testing, particularly molecular diagnostics. Modifications to improve the cell block method initially introduced more than a century ago have been made over the years. Though their value is acknowledged and they are widely used across laboratories, cell block preparations are not standardized and results of ancillary testing performed on them are inconsistent. This article reviews the state of cell blocks—summarizes the more common, currently available and used methods and their corresponding advantages and shortcomings, outlines the role of alternative techniques (eg, smears), and proposes methods to optimize results.

scholarly journals Outbreak of Histoplasmosis in a School Party That Visited a Cave in Belize: Role of Antigen Testing in Diagnosis

2002 ◽  
Vol 9 (1) ◽  
pp. 48-50 ◽  
Author(s):  
Jane A. Buxton ◽  
Meenakshi Dawar ◽  
L. Joseph Wheat ◽  
William A. Black ◽  
Nelson G. Ames ◽  
...  
Keyword(s):  
Antigen Testing

scholarly journals Role of Rapid Antigen Testing in Population-Based SARS-CoV-2 Screening

2021 ◽  
Vol 10 (17) ◽  
pp. 3854
Author(s):  
Vicente Martín-Sánchez ◽  
Tania Fernández-Villa ◽  
Ana Carvajal Urueña ◽  
Ana Rivero Rodríguez ◽  
Sofía Reguero Celada ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Diagnostic Test ◽  
Internal Validity ◽  
High Specificity ◽  
Population Based ◽  
Predictive Values ◽  
Asymptomatic Patients ◽  
Screening Performance ◽  
Antigen Testing

This study evaluates a population-based screening of asymptomatic people, using a rapid antigen diagnostic test (RADT), in areas of high transmission. To detect sources of SARS-CoV-2 infection, nasopharyngeal samples were taken and were tested using RADT. Confirmatory RT-qPCR tests were performed in both positive and negative cases. The internal validity of the RADT, the prevalence of infection, and the positive and negative predictive values (PPV and NPV) were estimated, based on the percentages of confirmed cases with 95% confidence interval. Of the 157,920 people registered, 50,492 participated in the screening; 50,052 were negative, and 440 were positive on the RADT (0.87%). A total of 221 positive RADT samples were reanalysed using RT-qPCR and 214 were confirmed as positive (96.8%; 95% CI: 93.5–98.7%), while 657 out of 660 negative RADT samples were confirmed as RT-qPCR negative (99.5%; 95% CI 98.7–99.9%). The sensitivity obtained was 65.1% (38.4–90.2%) and the specificity was 99.97% (99.94–99.99%). The prevalence of infection was 1.30% (0.95–2.13%). The PPVs were 95.4% (85.9–98.9%) and 97.9% (93.3–99.5%), respectively, while the NPVs were 99.7% (99.4–100%) and 99.2% (98.7–100%), respectively. The high specificity found allow us to report a high screening performance in asymptomatic patients, even in areas where the prevalence of infection was less than 2%.

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