Ritanserin: has no effect on patients with essential tremor, but improves resting tremor in patients with Parkinson's disease

ABSTRACT:Parkinsonian features, notably resting tremor may be seen in some essential tremor patients but the significance of those is unknown. The reported risk of parkinsonism in essential tremor patients varies from being unchanged to 35 times higher than expected. We studied 9 patients with essential tremor who had autopsies. In 6 of the 9 (66%) resting tremor was noted and in 3 (33%) cases fully developed parkinsonism was noted. The parkinsonism was consequent to neuroleptic usage in 2 and to basal ganglia status lacunaris and cribrosus in one case but no consistent abnormalities were noted in 3 essential tremor only and 3 essential tremor plus resting tremor cases. We conclude that resting tremor is an age-related natural evolution in some essential tremor patients. We recommend that the additional diagnosis of parkinsonism in the essential tremor be made only when resting tremor, bradykinesia and rigidity are all evident. The risk of ideopathic Parkinson's disease in essential tremor cases is similar to the general population.

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Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease

Brain Imaging and Behavior ◽

10.1007/s11682-019-00214-4 ◽

2020 ◽

Vol 14 (6) ◽

pp. 2606-2617

Author(s):

Jun-ying Li ◽

Zhong-jiao Lu ◽

Xue-ling Suo ◽

Nan-nan Li ◽

Du Lei ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Essential Tremor ◽

Brain Activity ◽

Resting Tremor ◽

Intrinsic Brain Activity

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Movement Disorders 1: Tourette’s Syndrome, Essential Tremor, and Parkinson’s Disease (DRAFT)

10.1093/med/9780190650261.003.0011 ◽

2018 ◽

Author(s):

Tamara Kaplan ◽

Tracey Milligan

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Essential Tremor ◽

Movement Disorders ◽

Postural Instability ◽

Tourette's Syndrome ◽

Tourette’S Syndrome ◽

Resting Tremor ◽

Kinetic Tremor ◽

Vocal Tics

The video in this chapter explores movement disorders, and focuses on Tourette’s Syndrome, Essential tremor, and Parkinson’s Disease. It outlines the characteristics of each, such as motor and vocal tics in Tourette’s Syndrome, postural or kinetic tremor in Essential tremor, and the four hallmark features of Parkinson’s Disease (bradykinesia, resting tremor, cogwheel rigidity, and postural instability).

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Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor

Diagnostics ◽

10.3390/diagnostics11020200 ◽

2021 ◽

Vol 11 (2) ◽

pp. 200

Author(s):

Basilio Vescio ◽

Rita Nisticò ◽

Antonio Augimeri ◽

Andrea Quattrone ◽

Marianna Crasà ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Essential Tremor ◽

Mobile Device ◽

Low Cost ◽

Digital Signal ◽

New Device ◽

Resting Tremor ◽

Phase Displacement ◽

Tremor Frequency

Involuntary tremor at rest is observed in patients with Parkinson’s disease (PD) or essential tremor (ET). Electromyography (EMG) studies have shown that phase displacement between antagonistic muscles at prevalent tremor frequency can accurately differentiate resting tremor in PD from that detected in ET. Currently, phase evaluation is qualitative in most cases. The aim of this study is to develop and validate a new mobile tool for the automated and quantitative characterization of phase displacement (resting tremor pattern) in ambulatory clinical settings. A new low-cost, wearable mobile device, called µEMG, is described, based on low-end instrumentation amplifiers and simple digital signal processing (DSP) capabilities. Measurements of resting tremor characteristics from this new device were compared with standard EMG. A good level of agreement was found in a sample of 21 subjects (14 PD patients with alternating resting tremor pattern and 7 ET patients with synchronous resting tremor pattern). Our results demonstrate that tremor analysis using µEMG is easy to perform and it can be used in routine clinical practice for the automated quantification of resting tremor patterns. Moreover, the measurement process is handy and operator-independent.

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