scholarly journals Significance of Parkinsonian Manifestations in Essential Tremor

1993 ◽  
Vol 20 (2) ◽  
pp. 114-117 ◽  
Author(s):  
A.H. Rajput ◽  
B. Rozdilsky ◽  
L. Ang ◽  
Alex Rajput
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
General Population ◽  
Essential Tremor ◽  
Natural Evolution ◽  
Resting Tremor ◽  
Age Related

ABSTRACT:Parkinsonian features, notably resting tremor may be seen in some essential tremor patients but the significance of those is unknown. The reported risk of parkinsonism in essential tremor patients varies from being unchanged to 35 times higher than expected. We studied 9 patients with essential tremor who had autopsies. In 6 of the 9 (66%) resting tremor was noted and in 3 (33%) cases fully developed parkinsonism was noted. The parkinsonism was consequent to neuroleptic usage in 2 and to basal ganglia status lacunaris and cribrosus in one case but no consistent abnormalities were noted in 3 essential tremor only and 3 essential tremor plus resting tremor cases. We conclude that resting tremor is an age-related natural evolution in some essential tremor patients. We recommend that the additional diagnosis of parkinsonism in the essential tremor be made only when resting tremor, bradykinesia and rigidity are all evident. The risk of ideopathic Parkinson's disease in essential tremor cases is similar to the general population.

Neuronal Activity of the Human Subthalamic Nucleus in the Parkinsonian and Nonparkinsonian State

2008 ◽  
Vol 100 (5) ◽  
pp. 2515-2524 ◽  
Author(s):  
F. Steigerwald ◽  
M. Pötter ◽  
J. Herzog ◽  
M. Pinsker ◽  
F. Kopper ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Essential Tremor ◽  
Subthalamic Nucleus ◽  
Neuronal Activity ◽  
Single Units ◽  
Exact Test ◽  
Spectral Peaks ◽  
Time Changes

We recorded resting-state neuronal activity from the human subthalamic nucleus (STN) during functional stereotactic surgeries. By inserting up to five parallel microelectrodes for single- or multiunit recordings and applying statistical spike-sorting methods, we were able to isolate a total of 351 single units in 65 patients with Parkinson's disease (PD) and 33 single units in 9 patients suffering from essential tremor (ET). Among these were 93 pairs of simultaneously recorded neurons in PD and 17 in ET, which were detected either by the same ( n = 30) or neighboring microelectrodes ( n = 80). Essential tremor is a movement disorder without any known basal ganglia pathology and with normal dopaminergic brain function. By comparing the neuronal activity of the STN in patients suffering from PD and ET we intended to characterize, for the first time, changes of basal ganglia activity in the human disease state that had previously been described in animal models of Parkinson's disease. We found a significant increase in the mean firing rate of STN neurons in PD and a relatively larger fraction of neurons exhibiting burstlike activity compared with ET. The overall proportion of neurons exhibiting intrinsic oscillations or interneuronal synchronization as defined by significant spectral peaks in the auto- or cross-correlations functions did not differ between PD and ET when considering the entire frequency range of 1–100 Hz. The distribution of significant oscillations across the theta (1–8 Hz), alpha (8–12 Hz), beta (12–35 Hz), and gamma band (>35 Hz), however, was uneven in ET and PD, as indicated by a trend in Fisher's exact test ( P = 0.05). Oscillations and pairwise synchronizations within the 12- to 35-Hz band were a unique feature of PD. Our results confirm the predictions of the rate model of Parkinson's disease. In addition, they emphasize abnormalities in the patterning and dynamics of neuronal discharges in the parkinsonian STN, which support current concepts of abnormal motor loop oscillations in Parkinson's disease.

Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease

2020 ◽  
Vol 14 (6) ◽  
pp. 2606-2617
Author(s):  
Jun-ying Li ◽  
Zhong-jiao Lu ◽  
Xue-ling Suo ◽  
Nan-nan Li ◽  
Du Lei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Brain Activity ◽  
Resting Tremor ◽  
Intrinsic Brain Activity

Movement Disorders 1: Tourette’s Syndrome, Essential Tremor, and Parkinson’s Disease (DRAFT)

2018 ◽  
Author(s):  
Tamara Kaplan ◽  
Tracey Milligan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Movement Disorders ◽  
Postural Instability ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Resting Tremor ◽  
Kinetic Tremor ◽  
Vocal Tics

The video in this chapter explores movement disorders, and focuses on Tourette’s Syndrome, Essential tremor, and Parkinson’s Disease. It outlines the characteristics of each, such as motor and vocal tics in Tourette’s Syndrome, postural or kinetic tremor in Essential tremor, and the four hallmark features of Parkinson’s Disease (bradykinesia, resting tremor, cogwheel rigidity, and postural instability).

scholarly journals Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease–related from age-related changes in basal ganglia function

2015 ◽  
Vol 36 (2) ◽  
pp. 1174-1182 ◽  
Author(s):  
Anders H. Andersen ◽  
Peter A. Hardy ◽  
Eric Forman ◽  
Greg A. Gerhardt ◽  
Don M. Gash ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Age Related ◽  
Age Related Changes

scholarly journals Development and Validation of a New Wearable Mobile Device for the Automated Detection of Resting Tremor in Parkinson’s Disease and Essential Tremor

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 200
Author(s):  
Basilio Vescio ◽  
Rita Nisticò ◽  
Antonio Augimeri ◽  
Andrea Quattrone ◽  
Marianna Crasà ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Mobile Device ◽  
Low Cost ◽  
Digital Signal ◽  
New Device ◽  
Resting Tremor ◽  
Phase Displacement ◽  
Tremor Frequency

Involuntary tremor at rest is observed in patients with Parkinson’s disease (PD) or essential tremor (ET). Electromyography (EMG) studies have shown that phase displacement between antagonistic muscles at prevalent tremor frequency can accurately differentiate resting tremor in PD from that detected in ET. Currently, phase evaluation is qualitative in most cases. The aim of this study is to develop and validate a new mobile tool for the automated and quantitative characterization of phase displacement (resting tremor pattern) in ambulatory clinical settings. A new low-cost, wearable mobile device, called µEMG, is described, based on low-end instrumentation amplifiers and simple digital signal processing (DSP) capabilities. Measurements of resting tremor characteristics from this new device were compared with standard EMG. A good level of agreement was found in a sample of 21 subjects (14 PD patients with alternating resting tremor pattern and 7 ET patients with synchronous resting tremor pattern). Our results demonstrate that tremor analysis using µEMG is easy to perform and it can be used in routine clinical practice for the automated quantification of resting tremor patterns. Moreover, the measurement process is handy and operator-independent.

Resting tremor only: a variant of Parkinson's disease or of essential tremor

1995 ◽  
Vol 130 (2) ◽  
pp. 215-219 ◽  
Author(s):  
Ming-Hong Chang ◽  
Tso-Wen Chang ◽  
Ping-Hong Lai ◽  
Chern-Guey Sy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Resting Tremor

Erratum to “resting tremor only: a variant of Parkinson's disease or of essential tremor”

1996 ◽  
Vol 135 (2) ◽  
pp. 187
Author(s):  
Ming-Hong Chang ◽  
Tso-Wen Chang ◽  
Ping-Hong Lai ◽  
Chern-Guey Sy
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Resting Tremor

scholarly journals Prevalence of essential tremor in an idiopathic Parkinson’s disease patient population

2015 ◽  
Vol 42 (S1) ◽  
pp. S31-S31
Author(s):  
A Rana ◽  
AM Qureshi ◽  
MA Rana ◽  
M Rahman ◽  
I Abdullah ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
General Population ◽  
Essential Tremor ◽  
Chart Review ◽  
Disease Patient ◽  
Retrospective Chart Review ◽  
Type Frequency ◽  
Exact Relationship ◽  
Mutually Independent

Objective of this study was assess the prevalence of Essential of Essential Tremor in Parkinson’s disease population Essential tremor (ET) is the most common movement disorders and is much more common than Parkinson’s disease, in general population. Essential Tremor and Parkinson’s disease (PD) tremor differ in type, frequency and distribution. Despite being two separate disorders, there have been cases reported of coexistence of ET-PD. Some studies have reported an increase in the incidence of ET in relatives of patients with PD, yet the risk of developing PD in ET patients has not been thoroughly investigated. Our study set out to determine the prevalence of precedent ET in PD patients. We conducted a retrospective chart review analysis of 332 idiopathic PD patients to determine how many of them had ET prior to the diagnosis of PD and the percentage of them who were also diagnosed with ET. Our results indicated that the prevalence of precedent ET among a population of idiopathic PD patients was not any higher than the prevalence of ET in a comparable general population. Our results support the notion that ET and PD are mutually independent disorders. Further studies are needed to understand the exact relationship between these two disorders

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