80-year-old men have elevated plasma concentrations of catecholamines but decreased plasma renin activity and aldosterone as compared to young men

We evaluated the effects of selective dietary chloride loading (without sodium) on plasma renin activity (PRA) and plasma aldosterone in the sodium-deprived Sprague-Dawley rat. Three groups of animals were fed one of the following diets for 13 days: 1) low NaCl; 2) high NaCl; or 3) low sodium, high chloride, provided as glycine hydrochloride. Compared with NaCl-deprived animals, PRA and plasma aldosterone were lower (P less than 0.01) in animals fed low sodium high chloride, whereas aldosterone in animals fed glycine hydrochloride was higher (P less than 0.01) than that of NaCl-deprived animals. In contrast, plasma concentrations of corticosterone and 18-hydroxycorticosterone were not increased by selective chloride loading. Glycine chloride-fed animals were acidotic and had elevated plasma concentrations of potassium and ionized calcium. Thus stimulation of aldosterone by selective chloride loading is not related to PRA or ACTH but may be due to a direct effect of acidosis or an indirect effect of acidosis on potassium and/or calcium. Additionally, selective chloride loading appears to stimulate the conversion of 18-hydroxycorticosterone to aldosterone.

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PLASMA CONCENTRATIONS OF NORADRENALINE AND ADRENALINE AND PLASMA RENIN ACTIVITY DURING EXTRADURAL BLOCKADE IN DOGS

British Journal of Anaesthesia ◽

10.1093/bja/52.3.305 ◽

1980 ◽

Vol 52 (3) ◽

pp. 305-311 ◽

Cited By ~ 13

Author(s):

B. STANEK ◽

M. SCHWARZ ◽

M. ZIMPFER ◽

G. RABERGER

Keyword(s):

Plasma Renin Activity ◽

Plasma Concentrations ◽

Plasma Renin ◽

Renin Activity ◽

Noradrenaline And Adrenaline

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DIURNAL VARIATIONS OF PLASMA ALDOSTERONE IN SUPINE MAN: RELATIONSHIP TO PLASMA RENIN ACTIVITY AND PLASMA CORTISOL

Acta Endocrinologica ◽

10.1530/acta.0.0800095 ◽

1975 ◽

Vol 80 (1) ◽

pp. 95-103 ◽

Cited By ~ 43

Author(s):

Helmut Armbruster ◽

Wilhelm Vetter ◽

Rainer Beckerhoff ◽

Jürg Nussberger ◽

Hans Vetter ◽

...

Keyword(s):

Plasma Renin Activity ◽

Plasma Cortisol ◽

Sodium Intake ◽

Plasma Concentrations ◽

Renin Angiotensin System ◽

Plasma Renin ◽

Plasma Aldosterone ◽

Renin Activity ◽

Dominant Factor ◽

Sodium Restriction

ABSTRACT In order to investigate the role of renin secretion and of ACTH on the circadian rhythm of plasma aldosterone (PA), plasma renin activity (PRA), plasma cortisol (PC) and PA were determined at short-time intervals in 10 normal supine men. Six subjects were studied under a normal sodium intake and 4 under sodium restriction. In 4 subjects the secretion of ACTH was suppressed by dexamethasone. Under normal sodium intake changes in PA seemed to be more in parallel with changes in PC than by those in PRA as indicated by a higher significant correlation between PA and PC than between PA and PRA in 3 of the 4 subjects. In 1 subject no correlation was observed between PA and PC despite visual synchronism between the plasma concentrations of both hormones. Under dexamethasone medication fluctuations in PA were followed by those in PRA while PC was less than 2 μg/100 ml. In the sodium restricted state, changes in PA were closely paralleled and significantly correlated to PRA while no correlation was seen between PA and PC. Under dexamethasone medication the significant correlation between PA and PRA persisted. Our results indicate that in normal supine man the influence of ACTH and renin on PA may vary with different sodium intakes. Under normal sodium intake ACTH seems to be the dominant factor controlling PA, whereas under sodium restriction changes in PA are mediated through the renin angiotensin system. When the secretion of ACTH is suppressed by dexamethasone, renin controls PA both under normal and low sodium intake.

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ELEVATED PLASMA RENIN ACTIVITY AND “BIG RENIN” IN MESOBLASTIC NEPHROMA

Pediatric Research ◽

10.1203/00006450-197704000-01088 ◽

1977 ◽

Vol 11 (4) ◽

pp. 551-551

Author(s):

Ted P Groshong ◽

Judith H Miles ◽

John H Bauer ◽

Myron Weinberger ◽

Nasrollah Hakami ◽

...

Keyword(s):

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Mesoblastic Nephroma ◽

Elevated Plasma

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Relation of Elevated Plasma Renin Activity at Baseline to Cardiac Events in Patients With Angiographically Proven Coronary Artery Disease

The American Journal of Cardiology ◽

10.1016/j.amjcard.2010.04.040 ◽

2010 ◽

Vol 106 (6) ◽

pp. 764-769 ◽

Cited By ~ 38

Author(s):

Joseph B. Muhlestein ◽

Heidi T. May ◽

Tami L. Bair ◽

Margaret F. Prescott ◽

Benjamin D. Horne ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Elevated Plasma ◽

Cardiac Events ◽

Artery Disease

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Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00660.2002 ◽

2003 ◽

Vol 284 (4) ◽

pp. R1031-R1036 ◽

Cited By ~ 12

Author(s):

Cindy Wang ◽

Julie Chao ◽

Lee Chao

Keyword(s):

Blood Pressure ◽

Gene Transfer ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Plasma Aldosterone ◽

Renin Activity ◽

Sodium Reabsorption ◽

Elevated Plasma ◽

Aldosterone Production ◽

Renal Kallikrein

Prostasin has been demonstrated to be an activator of epithelial sodium channels in cultured renal and bronchial epithelial cells. In this study, we evaluated the effects of adenovirus-mediated gene transfer of human prostasin on blood pressure regulation and sodium reabsorption in Wistar rats. Expression of human prostasin mRNA was identified in rat adrenal gland, liver, kidney, heart, lung, and aorta, and immunoreactive human prostasin was detected in the circulation and urine of rats receiving prostasin gene transfer. A single injection of adenovirus carrying the prostasin gene caused prolonged increases in blood pressure for 3–4 wk. Blood pressure increase was accompanied by elevated plasma aldosterone levels and reduced plasma renin activity. The increase in blood pressure and plasma aldosterone levels as well as the reduction of plasma renin activity correlated with the expression of human prostasin transgene. Elevated plasma aldosterone levels were detected at 3 days after gene transfer before the development of hypertension, indicating that stimulation of mineralocorticoid production is the primary target of prostasin. Prostasin gene transfer significantly reduced urinary K+ excretion but increased urinary Na+ and kallikrein excretion. Elevated renal kallikrein levels promote natriuresis, which may lead to sodium escape and prevent further increases of blood pressure after prostasin gene transfer. In summary, these results suggest that prostasin participates in blood pressure and electrolyte homeostasis by regulating the renin-angiotensin-aldosterone and kallikrein-kinin systems.

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