scholarly journals Effects of naloxone on Morris water maze learning in the rat: Enhanced acquisition with pretraining but not posttraining administration

Psychobiology ◽  
1989 ◽  
Vol 17 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Michael W. Decker ◽  
Ines B. Introini-Collison ◽  
James L. Mcgaugh
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning

scholarly journals Involvement of cholinergic systems in deficit of Morris water-maze learning induced by baclofen.

1995 ◽  
Vol 67 ◽  
pp. 299
Author(s):  
Yutaka Nakagawa ◽  
Yoshinori Ishibashi ◽  
Toshio Yashli ◽  
Eijim Taeashira
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning ◽  
Cholinergic Systems

Protein tyrosine phosphatase alpha (PTPα) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety

2003 ◽  
Vol 984 (1-2) ◽  
pp. 1-10 ◽  
Author(s):  
Matthew R Skelton ◽  
Sathivel Ponniah ◽  
Dennis Z.-M Wang ◽  
Thomas Doetschman ◽  
Charles V Vorhees ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Morris Water Maze ◽  
Protein Tyrosine Phosphatase ◽  
Knockout Mice ◽  
Water Maze ◽  
Tyrosine Phosphatase ◽  
Maze Learning ◽  
Protein Tyrosine

scholarly journals Unraveling Early Signs of Navigational Impairment in APPswe/PS1dE9 Mice Using Morris Water Maze

2020 ◽  
Vol 14 ◽  
Author(s):  
Smitha Karunakaran
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning ◽  
Wild Type ◽  
Behavioral Deficits ◽  
Model Of Alzheimer’S Disease ◽  
Error Learning ◽  
Early Indicators

Mild behavioral deficits, which are part of normal aging, can be early indicators of an impending Alzheimer's disease. Using the APPswe/PS1dE9 (APP/PS1) mouse model of Alzheimer's disease, we utilized the Morris water maze spatial learning paradigm to systematically evaluate mild behavioral deficits that occur during the early stages of disease pathogenesis. Conventional behavioral analysis using this model indicates that spatial memory is intact at 2 months of age. In this study, we used an alternative method to analyze the behavior of mice, aiming to gain a better understanding of the nature of cognitive deficits by focusing on the unsuccessful trials during water maze learning rather than on the successful ones. APP/PS1 mice displayed a higher number of unsuccessful trials during the initial days of training, unlike their wild-type counterparts. However, with repeated trial and error, learning in APP/PS1 reached levels comparable to that of the wild-type mice during the later days of training. Individual APP/PS1 mice preferred a non-cognitive search strategy called circling, which led to abrupt learning transitions and an increased number of unsuccessful trials. These findings indicate the significance of subtle intermediate readouts as early indicators of conditions such as Alzheimer's disease.

scholarly journals Deficits of Morris water maze learning in rats with striatal kainic acid lesions.

2000 ◽  
Vol 70 (6) ◽  
pp. 469-476
Author(s):  
Sachiko Takahama ◽  
Yukio Ichitani
Keyword(s):  
Kainic Acid ◽  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning

scholarly journals Modafinil and memory: Effects of modafinil on Morris water maze learning and Pavlovian fear conditioning.

2009 ◽  
Vol 123 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Tristan Shuman ◽  
Suzanne C. Wood ◽  
Stephan G. Anagnostaras
Keyword(s):  
Fear Conditioning ◽  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning ◽  
Memory Effects ◽  
Pavlovian Fear Conditioning

scholarly journals Effects of acute and repeated administration of Staphylococcal enterotoxin A on Morris water maze learning, corticosterone and hippocampal IL-1β and TNFα

2011 ◽  
Vol 25 (5) ◽  
pp. 938-946 ◽  
Author(s):  
Randall T. Woodruff ◽  
Kristen M. Schorpp ◽  
Agniesczka J. Lawrenczyk ◽  
Trisha Chakraborty ◽  
Alexander W. Kusnecov
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Repeated Administration ◽  
Maze Learning ◽  
Staphylococcal Enterotoxin ◽  
Staphylococcal Enterotoxin A

Nonlinear Mixed Effects Modeling of Morris Water Maze Learning

2008 ◽  
Author(s):  
Michael E. Young ◽  
M. H. Clark ◽  
Andrea M. Goffus ◽  
Michael R. Hoane
Keyword(s):  
Morris Water Maze ◽  
Water Maze ◽  
Maze Learning ◽  
Mixed Effects ◽  
Nonlinear Mixed Effects ◽  
Nonlinear Mixed Effects Modeling ◽  
Mixed Effects Modeling
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