Changes in lymphoid organs of Ames dwarf mice after treatment with growth hormone, prolactin or ectopic pituitary transplants

1992 ◽  
Vol 15 (8) ◽  
pp. 587-595 ◽  
Author(s):  
M. A. Villanua ◽  
A. Szary ◽  
A. Bartke ◽  
A. I. Esquifino
Keyword(s):  
Growth Hormone ◽  
Lymphoid Organs ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice.

Endocrinology ◽  
1993 ◽  
Vol 132 (6) ◽  
pp. 2518-2524 ◽  
Author(s):  
K Tang ◽  
A Bartke ◽  
C S Gardiner ◽  
T E Wagner ◽  
J S Yun
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Gonadotropin Secretion ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Thymostimulin effects on lymphoid organs in Ames dwarf mice

1993 ◽  
Vol 128 (1) ◽  
pp. 74-80
Author(s):  
Maria A Villanua ◽  
Agnieszka Szary ◽  
Ana I Esquifino ◽  
Andrzej Bartke
Keyword(s):  
Immune Function ◽  
Lymphoid Organs ◽  
Plasma Prolactin ◽  
Nk Activity ◽  
Spleen Cells ◽  
Adult Mice ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Spleen Lymphocytes ◽  
Dwarf Mice

This work was undertaken to study the effects of thymostimulin (TP-1) on the immune function in Ames dwarf mice, and to relate these effects to PRL and/or GH deficiency in these animals. Male Ames dwarf mice implanted with pituitaries from normal mice under the kidney capsule, sham-operated dwarf mice and normal immature or adult mice were injected daily for five days with TP-1. In comparison to normal animals, sham-operated dwarf mice had markedly lower body, thymus and spleen weights, as well as a lower number of lymphocytes in the spleen and in the thymus and the natural killer (NK) activity of spleen lymphocytes. Ectopic pituitary transplants produced the expected enhancement of body weight gain and increased spleen and thymus weights, which reached the values found in normal (non-dwarf) animals. The numbers of lymphocytes in the spleen and thymus were significantly increased in pituitary-grafted dwarf mice, but the grafts did not modify the cytotoxic activity of NK spleen cells, or the number of peripheral white blood cells (PWBC). In sham-operated dwarf mice, TP-1 treatment did not modify the number of cells in the spleen and thymus, or the NK activity. In pituitary-grafted dwarf mice, treatment with TP-1 induced an increase in the number of spleen lymphocytes and in the NK activity of spleen cells without affecting the weight of lymphoid organs or the number of thymic cells. Plasma prolactin (PRL) and growth hormone (GH) levels of pituitary-grafted dwarf mice were not changed after TP-1 administration. Surprisingly, the NK activity of spleen lymphocytes in normal adult mice was greatly increased after TP-1 administration. These findings suggest that the thymic extract TP-1 can exert a major stimulatory influence on NK activity of spleen lymphocytes in adult mice, and potentiate some of the stimulatory effects of hormones secreted by ectopic pituitary transplants on the immune function of Ames dwarf mice. These effects are not mediated by modifications of the release of PRL or GH.

Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice

2005 ◽  
Vol 126 (3) ◽  
pp. 389-398 ◽  
Author(s):  
Holly M. Brown-Borg ◽  
Sharlene G. Rakoczy ◽  
Eric O. Uthus
Keyword(s):  
Growth Hormone ◽  
Glutathione Metabolism ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Body Composition of Prolactin-, Growth Hormone-, and Thyrotropin-Deficient Ames Dwarf Mice

Endocrine ◽  
2003 ◽  
Vol 20 (1-2) ◽  
pp. 149-154 ◽  
Author(s):  
Mark L. Heiman ◽  
Frank C. Tinsley ◽  
Julie A. Mattison ◽  
Steven Hauck ◽  
Andrzej Bartke
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Growth Hormone Alters Components of the Glutathione Metabolic Pathway in Ames Dwarf Mice

2004 ◽  
Vol 1019 (1) ◽  
pp. 317-320 ◽  
Author(s):  
HOLLY M. BROWN-BORG ◽  
SHARLENE G. RAKOCZY ◽  
ERIC O. UTHUS
Keyword(s):  
Growth Hormone ◽  
Metabolic Pathway ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Ectopic pituitary transplants restore immunocompetence in Ames dwarf mice

1991 ◽  
Vol 125 (1) ◽  
pp. 67-72 ◽  
Author(s):  
A. I. Esquifino ◽  
M. A. Villanúa ◽  
A. Szary ◽  
J. Yau ◽  
A. Bartke
Keyword(s):  
Growth Hormone ◽  
Direct Action ◽  
White Blood Cells ◽  
Natural Killer Activity ◽  
Plasma Prolactin ◽  
Killer Activity ◽  
Male And Female ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Abstract. This work was undertaken to study the effects of prolactin on immune function in Ames dwarf mice. For that purpose, adult Ames dwarf mice were implanted with pituitaries from normal mice under the kidney capsule. Ectopic pituitary transplants produced the expected increase in plasma prolactin levels in male and female dwarf mice as compared to sham-operated dwarf or untreated normal mice. Body weight was significantly increased in pituitary-grafted dwarf mice of both sexes, but did not reach the values found in normal (non-dwarf) animals. Pituitary transplants induced an increase in thymus weight and in the number of lymphocytes in the thymus in dwarf mice of both sexes as compared to sham-operated dwarf controls. The weight of the thymus in grafted dwarf mice remained below values found in normal mice, while the number of thymic lymphocytes became indinstinguishable from those recorded in normal mice, Effects of pituitary transplants on the spleen were similar to those described for the thymus; however, neither the weight nor the lymphocyte number in pituitary-grafted dwarfs reached the values found in normal animals. Natural killer activity of spleen lymphocytes from pituitary-grafted male and female dwarf mice was greatly enhanced as compared to lymphocytes from sham-operated dwarfs. This effect was greater in males than in females. The number of white blood cells in pituitary-grafted male dwarf mice was increased and indistinguishable from the values found in normal males. Surprisingly, this effect was absent in the females. These findings suggest that hormones secreted by the transplants, most likely prolactin and growth hormone, can enhance the immune response. This action may be mediated by direct action of prolactin and/or growth hormone on immune cells or by indirect effects.

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