Nuclear DNA content of medullary thyroid carcinoma in a large family with the MEN-2A syndrome

1991 ◽  
Vol 14 (4) ◽  
pp. 261-264 ◽  
Author(s):  
H. R. Haak ◽  
C. J. Cornelisse ◽  
B. M. Goslings ◽  
G. J. Fleuren
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Large Family ◽  
Medullary Thyroid ◽  
Men 2A

Prognostic value of nuclear DNA content in medullary thyroid carcinoma

1985 ◽  
Vol 9 (6) ◽  
pp. 980-986 ◽  
Author(s):  
Martin Bäckdahl ◽  
Eva Tallroth ◽  
Gert Auer ◽  
Gun Forsslund ◽  
Per -Ola Granberg ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Dna Content ◽  
Prognostic Value ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Medullary Thyroid

scholarly journals Nuclear DNA content and survival in medullary thyroid carcinoma

Cancer ◽  
1990 ◽  
Vol 65 (3) ◽  
pp. 511-517 ◽  
Author(s):  
Eva Tallroth Ekman ◽  
Ulla Bergholm ◽  
Martin Bäckdahl ◽  
Hans-Olov Adami ◽  
Reinhold Bergström ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Medullary Thyroid

Prognostic impact of nuclear DNA content in medullary thyroid carcinoma; a retrospective pilot study

1985 ◽  
Vol 4 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Eva Tallroth ◽  
Martin Bäckdahl ◽  
Gert Auer ◽  
Gun Forsslund ◽  
Per-Ola Granberg ◽  
...  
Keyword(s):  
Pilot Study ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Prognostic Impact ◽  
Medullary Thyroid

Additional Endocrinopathies in a Large Family with Familial Medullary Thyroid Carcinoma: Implications for Treatment and Follow-Up

2015 ◽  
pp. 102-107
Author(s):  
C. Schaap ◽  
A. M. J. Moers ◽  
J. K. Ploos van Amstel ◽  
J. W. M. H�ppener ◽  
C. J. M. Lips
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Large Family ◽  
Medullary Thyroid ◽  
Familial Medullary Thyroid Carcinoma

Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma

1998 ◽  
Vol 21 (6) ◽  
pp. 358-364 ◽  
Author(s):  
E. Chiefari ◽  
D. Russo ◽  
D. Giuffrida ◽  
G. A. Zampa ◽  
D. Meringolo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Sporadic Medullary Thyroid Carcinoma ◽  
Medullary Thyroid ◽  
Men 2B ◽  
Men 2A

RET oncogene mutations in a large Korean kindred with familial medullary thyroid carcinoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6066-6066
Author(s):  
Y. Lee ◽  
H. Park ◽  
J. Jung ◽  
Y. Lim ◽  
S. Uchino
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Germ Line ◽  
Radical Neck Dissection ◽  
Gene Mutations ◽  
Large Family ◽  
Carrier Status ◽  
Medullary Thyroid ◽  
Familial Medullary Thyroid Carcinoma ◽  
The Family

6066 Background: Familial medullary thyroid carcinoma (FMTC) is related to germ-line mutations in the RET proto-oncogene. The mutations concern mainly cystein residues in exons 10 and 11, whereas noncystein mutations in exons 13–16 are rare. These mutations have been recorded in the different populations, but to date there is no corresponding study in Korean families. In this study, we identify the RET mutations in the Korean family with FMTC and propose therapeutic approach in managing the disorder. Methods: The large family consists of 4 generations with a total of 32 individuals. There was a history of MTC in five members of the family. The index case was a 67-yr- old woman who underwent total thyroidectomy and both modified radical neck dissection in our hospital at the age of 48. We analysed exons 10, 11, 13, 14, 15 and 16 in index patients using DNA sequencing. Twenty-nine subjects from the family were clinically assessed and subsequently molecularly analysed for the presence of RET gene mutations. Results: We have found a missense TGC?AGC mutation at codon 618 in Exon 10. This transversion leads to the substitution of cystein with serin. The mutation was detected in all five MTC patients as well as in 6 asymptomatic relatives. The mutation shows a wide clinical heterogenecity, as there are carrier patients with age of diagnosis ranging from 9 to 64 years. Conclusions: It is likely that the mutation causes FMTC, because no other mutation was found in RET. This study showed 100% accordance between presence of the disease and gene carrier status is reported. Total preventive thyroidectomy has been recommended in all carriers of RET genetic defects. No significant financial relationships to disclose.

Nuclear DNA Content in Anaplastic Giant-Cell Thyroid Carcinoma

1989 ◽  
Vol 12 (5) ◽  
pp. 442-446 ◽  
Author(s):  
Eva Tallroth Ekman ◽  
Göran Wallin ◽  
Martin Bäckdahl ◽  
Torsten Löwhagen ◽  
Gert Auer
Keyword(s):  
Thyroid Carcinoma ◽  
Giant Cell ◽  
Dna Content ◽  
Nuclear Dna ◽  
Nuclear Dna Content

MEN 2A with double mutation in RET gene: Ectopic ACTH production in medullary thyroid carcinoma

2016 ◽  
Vol 146 (9) ◽  
pp. 419-420
Author(s):  
Jessica Ares ◽  
Lucía Díaz-Naya ◽  
Alicia Martín-Nieto ◽  
Joaquín Pertierra
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Ectopic Acth ◽  
Double Mutation ◽  
Medullary Thyroid ◽  
Ret Gene ◽  
Ectopic Acth Production ◽  
Men 2A
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