Glucose and free fatty acid turnover in Cushing’s syndrome

The accuracy of non-steady-state equations for measuring changes in free fatty acid rate of appearance (Ra) is unknown. In the present study, endogenous lipolysis (traced with [14C]-linoleate) was pharmacologically suppressed in six conscious mongrel dogs. A computer-responsive infusion pump was then used to deliver an intravenous oleic acid emulsion in both constant and linear gradient infusion modes. Both non-steady-state equations with various effective volumes of distribution (V) and steady-state equations were used to measure oleate Ra [( 14C]oleate). Endogenous lipolysis did not change during the experiment. When oleate Ra increased in a linear gradient fashion, only non-steady-state equations with a large (150 ml/kg) V resulted in erroneous values (9% overestimate, P less than 0.05). In contrast, when oleate Ra decreased in a similar fashion, steady-state and standard non-steady-state equations (V = plasma volume = 50 ml/kg) overestimated total oleate Ra (18 and 7%, P less than 0.001 and P less than 0.05, respectively). Overall, non-steady-state equations with an effective V of 90 ml/kg (1.8 x plasma volume) allowed the most accurate estimates of oleate Ra.

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Free fatty acid turnover and lipolysis in septic mechanically ventilated cancer-bearing humans

Metabolism ◽

10.1016/0026-0495(88)90078-9 ◽

1988 ◽

Vol 37 (7) ◽

pp. 618-625 ◽

Cited By ~ 17

Author(s):

M.R. Levinson ◽

J.S. Groeger ◽

M. Jeevanandam ◽

M.F. Brennan

Keyword(s):

Fatty Acid ◽

Free Fatty Acid ◽

Mechanically Ventilated ◽

Fatty Acid Turnover

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Plasma free fatty acid turnover in carbon tetrachloride-treated rats

Metabolism ◽

10.1016/0026-0495(65)90118-6 ◽

1965 ◽

Vol 14 (9) ◽

pp. 1023-1026 ◽

Cited By ~ 4

Author(s):

Michael C. Schotz ◽

Nome Baker ◽

Margarito N. Chavez

Keyword(s):

Fatty Acid ◽

Carbon Tetrachloride ◽

Free Fatty Acid ◽

Plasma Free Fatty Acid ◽

Fatty Acid Turnover

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Plasma Free Fatty Acid Turnover and Oxidation during Fat‐Free and Intralipid TPN

Journal of Parenteral and Enteral Nutrition ◽

10.1177/0148607180004006572 ◽

1980 ◽

Vol 4 (6) ◽

pp. 572-574 ◽

Cited By ~ 4

Author(s):

Charles L. Skutches ◽

Richard N. Myers ◽

Pavle Paul ◽

Robert D. Smink ◽

George A. Reichard

Keyword(s):

Fatty Acid ◽

Free Fatty Acid ◽

Plasma Free Fatty Acid ◽

Fatty Acid Turnover

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Increased free fatty acid turnover in CSF during hypotension in dogs

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1979.236.6.h802 ◽

1979 ◽

Vol 236 (6) ◽

pp. H802-H807

Author(s):

E. Fritschka ◽

J. L. Ferguson ◽

J. J. Spitzer

Keyword(s):

Blood Flow ◽

Cerebrospinal Fluid ◽

Cerebral Blood Flow ◽

Fatty Acid ◽

Free Fatty Acid ◽

Lateral Ventricle ◽

Turnover Rates ◽

Fatty Acid Turnover ◽

Ventriculocisternal Perfusion ◽

Arteriovenous Difference

Cerebrospinal fluid turnover rates of FFA were investigated using ventriculocisternal perfusion techniques. Seven conscious dogs were perfused over a 6-h period from the lateral ventricle to the cisterna magna with mock cerebrospinal fluid (CSF) containing [14C]palmitate and 100 mumol/l of FFA. One hundred and twenty minutes of perfusion were allowed to establish equilibrium of the FFA concentration in the ventricular space. Moderate hemorrhage hypotension was then induced (MABP greater than 60 mmHg) for 3 h, followed by rapid retransfusion and a final hour of perfusion. Cerebral blood flow did not change significantly (45 +/- 6 before, 53 +/- 6 after hemorrhage, and 47 +/- 5 ml.min-1. 100 g-1 after retransfusion). Cerebral arteriovenous difference of O2, glucose, and pH increased significantly during hemorrhage. Hypotension was accompanied by an increased turnover of FFA from 60 to 120 nmol/min (P less than 0.01) in the CSF. FFA turnover was directly correlated with the fatty acid concentration of the CSF (r = 0.77). It is speculated that the increased fatty acid turnover during hypotension may indicate increased phospholipid turnover and/or increased oxidation by tissues lining the ventricular space.

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