Mutational analysis of rhodotorulic acid synthesis in Rhodotorula pilimanae

Author(s):  
Alexander Liu ◽  
J. B. Neilands





1991 ◽  
Vol 69 (7) ◽  
pp. 1107-1116 ◽  
Author(s):  
Frédéric Chaubet ◽  
Marguerite Nguyen Van Duong ◽  
Jacques Courtieu ◽  
Alain Gaudemer ◽  
Aurore Gref ◽  
...  

With a view to preparing stable iron(III) complexes that can be used as contrast agents in magnetic resonance imaging, we have prepared a series of dihydroxamates that are analogs of rhodotorulic acid, a natural siderophore. These new ligands have been synthesized by condensation of 2,6-pyridine dicarboxylic acid chloride with protected N-aminopropyl-N-acetylhydroxylamine. In addition to the ligand derived from 2,6-pyridine dicarboxylic acid, four other ligands have thus been prepared, having substituents O-C2H5, O-nC5H11, O-nC3H6CN, O-nC4H8NH2•HCl. respectively, in the 4 position. Key words: medical imaging, contrast agents, rhodotorulic acid, synthesis of analogs.







2004 ◽  
Vol 36 (05) ◽  
Author(s):  
U Schmidt ◽  
M Rosenhagen ◽  
F Holsboer ◽  
T Rein
Keyword(s):  


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