Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis

2001 ◽  
Vol 50 (9) ◽  
pp. 474-482 ◽  
Author(s):  
M. Yamasaki ◽  
K. Sasaki ◽  
N. Mizutani ◽  
T. Nabe ◽  
Y. Sakura ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Pig Model ◽  
Antigen Challenge ◽  
Pharmacological Characterization ◽  
Guinea Pig Model

Time Course of Changes in Absorption of Macromolecule through the Nasal Mucosa after Antigen Challenge in Guinea Pig Model of Allergic Rhinitis

2000 ◽  
Vol 109 (12) ◽  
pp. 1120-1124 ◽  
Author(s):  
Akiyoshi Konno ◽  
Hiroshi Nagata ◽  
Tsutomu Numata ◽  
Nobuhisa Terada ◽  
Hideaki Motosugi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Nasal Mucosa ◽  
Time Course ◽  
Pig Model ◽  
Antigen Challenge ◽  
Guinea Pig Model

scholarly journals Effects of Bifidobacterium bifidum G9-1 on Nasal Symptoms in a Guinea Pig Model of Experimental Allergic Rhinitis

2011 ◽  
Vol 30 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Satoru Tsunemine ◽  
Yasuhiro Isa ◽  
Masaki Shimakawa ◽  
Hiroshi Ohno ◽  
Hideki Yamamura
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Bifidobacterium Bifidum ◽  
Pig Model ◽  
Nasal Symptoms ◽  
Guinea Pig Model ◽  
Experimental Allergic

scholarly journals Pharmacological analyses of mechanisms underlying nasal blockage using a guinea-pig model of allergic rhinitis

2005 ◽  
Vol 125 (5) ◽  
pp. 271-277
Author(s):  
Takeshi Nabe ◽  
Nobuaki Mizutani ◽  
Shigekatsu Kohno
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Pig Model ◽  
Nasal Blockage ◽  
Guinea Pig Model

Effect of TA-270, a novel quinolinone derivative, on antigen-induced nasal blockage in a guinea pig model of allergic rhinitis

2009 ◽  
Vol 602 (1) ◽  
pp. 138-142 ◽  
Author(s):  
Nobuaki Mizutani ◽  
Yasuo Aoki ◽  
Takeshi Nabe ◽  
Mitsuteru Ishiwara ◽  
Shin Yoshino ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Pig Model ◽  
Nasal Blockage ◽  
Guinea Pig Model

scholarly journals Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis

2007 ◽  
Vol 105 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Hai Yan Han ◽  
Takeshi Nabe ◽  
Nobuaki Mizutani ◽  
Masanori Fujii ◽  
Tetsuya Terada ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Oral Administration ◽  
Pig Model ◽  
Nasal Blockage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Guinea Pig Model

scholarly journals Effects of the Anti-allergic Agent (Mizolastine) in Guinea Pig Model of Allergic Rhinitis

1997 ◽  
Vol 36 (2) ◽  
pp. 111-116
Author(s):  
Shin-ichiro Narita ◽  
Kohji Asakura ◽  
Akikatsu Kataura ◽  
Fumiko Sano ◽  
Noboru Yamada
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis

2014 ◽  
Vol 307 (2) ◽  
pp. G149-G157 ◽  
Author(s):  
Youtian Hu ◽  
Zhenyu Liu ◽  
Xiaoyun Yu ◽  
Pankaj J. Pasricha ◽  
Bradley J. Undem ◽  
...  
Keyword(s):  
Mast Cells ◽  
Guinea Pig ◽  
Eosinophilic Esophagitis ◽  
Sensory Nerve ◽  
Pig Model ◽  
Antigen Challenge ◽  
Esophageal Wall ◽  
Patch Clamp Recording ◽  
Peripheral Tissues ◽  
Guinea Pig Model

Eosinophilic esophagitis (EoE) is characterized with eosinophils and mast cells predominated allergic inflammation in the esophagus and present with esophageal dysfunctions such as dysphagia, food impaction, and heartburn. However, the underlying mechanism of esophageal dysfunctions is unclear. This study aims to determine whether neurons in the vagal sensory ganglia are modulated in a guinea pig model of EoE. Animals were actively sensitized by ovalbumin (OVA) and then challenged with aerosol OVA inhalation for 2 wk. This results in a mild esophagitis with increases in mast cells and eosinophils in the esophageal wall. Vagal nodose and jugular neurons were disassociated, and their responses to acid, capsaicin, and transient receptor potential vanilloid type 1 (TRPV1) antagonist AMG-9810 were studied by calcium imaging and whole cell patch-clamp recording. Compared with naïve animals, antigen challenge significantly increased acid responsiveness in both nodose and jugular neurons. Their responses to capsaicin were also increased after antigen challenge. AMG-9810, at a concentration that blocked capsaicin-evoked calcium influx, abolished the increase in acid-induced activation in both nodose and jugular neurons. Vagotomy strongly attenuated those increased responses of nodose and jugular neurons to both acid and capsaicin induced by antigen challenge. These data for the first time demonstrated that prolonged antigen challenge significantly increases acid responsiveness in vagal nodose and jugular ganglia neurons. This sensitization effect is mediated largely through TRPV1 and initiated at sensory nerve endings in the peripheral tissues. Allergen-induced enhancement of responsiveness to noxious stimulation by acid in sensory nerve may contribute to the development of esophageal dysfunctions such as heartburn in EoE.

Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis

2011 ◽  
Vol 667 (1-3) ◽  
pp. 389-395 ◽  
Author(s):  
Daisuke Kajiwara ◽  
Hiroki Aoyagi ◽  
Kazuhiko Shigeno ◽  
Michinori Togawa ◽  
Katsunao Tanaka ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pig ◽  
Nasal Obstruction ◽  
Pig Model ◽  
Prostaglandin D Synthase ◽  
Guinea Pig Model ◽  
Experimental Allergic
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