Renal Stones and Primary Hyperparathyroidism: Natural History of Renal Stone Disease after Successful Parathyroidectomy

1999 ◽  
Vol 23 (2) ◽  
pp. 173-176 ◽  
Author(s):  
Charlotte L. Mollerup ◽  
Helle Lindewald
Keyword(s):  
Natural History ◽  
Primary Hyperparathyroidism ◽  
Renal Stone ◽  
Renal Stones ◽  
Stone Disease ◽  
Renal Stone Disease ◽  
History Of

MO1029RENAL STONE DISEASE IN 193 PONTIFFS: FROM VIGILUS TO PIUS VIII (537-1830)*

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Natale Gaspare De Santo ◽  
Carmela Bisaccia ◽  
Luca Salvatore De Santo
Keyword(s):  
Time Course ◽  
Renal Stone ◽  
Renal Stones ◽  
Stone Disease ◽  
Postmortem Examination ◽  
Renal Stone Disease ◽  
European Universities ◽  
Stone Formers ◽  
Age Related ◽  
History Of

Abstract Background and Aims The history of popes is an untapped treasure for historian of medicine for many reasons including i. number, ii. richness of documents available on their lives, iii. gender homogeneity, iiii. Long lasting lives, v. their affluence, vi. number of archiaters and personal physicians and surgeon of high professional level, viii. lived for many years in the same environment (Rome). Taking into consideration the availability of documents from 1100 onward (10 centuries of European history), popes represent good models to study a. the diseases of popes, b. social medicine, c. history of European universities and beyond, d. the history of hospitals, e. the history of archiaters, and f. the diseases of power. We are studying renal stone disease in popes from St Peter to John Paul II (34-2005). Preliminary results on gouty popes have been presented at ERA-EDTA Congress in Budapest and Milan pointing that out 20 gouty pontiffs 12 were stone formers or died because of its complications and 6 popes died because of non-gouty renal stones. The goal of this study is to provide an historical outline on renal stone disease in gouty and not gouty popes reigning in the years 537-1830 (from Vigilius―the 1st stone former pope―to Pius VIII, the last gouty pope). Methods We have studied history of popes on many books including those authored by von Ranke, von Pastor, de Novaes, Henrion, Paravicini Bagliani, Reardon, Rendina, Ceccarelli and Cosmacini. We have also studied the histories of archiaters of Platina and Marini. Results 25 out 193 popes were found gouty. Their mean age at start of pontiff was 64.6 and 70.6 at death, that nearly correspond to the time-course decline of age-related uric acid excretion. Thirteen of these popes had histories, signs, symptoms, and /or postmortem examination compatible with a diagnosis of renal stone disease. Six of them died with uremia, 4 were hydropics, 6 died because of stroke. In addition we have also outlined the narratives of 14 non gouty popes who had renal stone disease. The last pope affected by renal stone disease was Pius VI (1775-1779) , the last gouty popes was Pius VIII (1829-1830). Conclusion We have excluded from gouty popes Alexander VII erroneously defined gouty by Giuseppe De Novaes in 1815 and also excluded John IX since his gout―hypothesized by Wendy J Reardon in 1971―is not supported by documents. There are a few available specific data on the topic. A fundamental contribution was published by Lorenzo Gualino in 1934. He reported on 19 gouty popes, 12 of whom with histories or signs, or symptoms, and/or postmortem examination confirming renal stone diseaase. He also reported on 8 non gouty popes suffering from or died of renal stone disease. The findings should be matched also with those of Giovanni Ceccarelli (2001) who reported on 11 gouty popes 6 presenting with signs of stones and five dying anuric and/or hydropic. This paper includes on all popes with renal stone disease. Stroke and heart failure in gouty popes are a priority. In the last 2 centuries renal stone disease was no more a papal disease.

Primary Hyperparathyroidism: Is There an Increased Prevalence of Renal Stone Disease?

2008 ◽  
Vol 191 (3) ◽  
pp. 908-911 ◽  
Author(s):  
Jane M. Suh ◽  
John J. Cronan ◽  
Jack M. Monchik
Keyword(s):  
Primary Hyperparathyroidism ◽  
Renal Stone ◽  
Stone Disease ◽  
Renal Stone Disease

scholarly journals Renal stones

2018 ◽  
Vol 56 (1) ◽  
pp. 15-27 ◽  
Author(s):  
Adie Viljoen ◽  
Rabia Chaudhry ◽  
John Bycroft
Keyword(s):  
Risk Assessment ◽  
High Risk ◽  
Renal Stone ◽  
Surgical Intervention ◽  
Recurrent Disease ◽  
Renal Stones ◽  
Evidence Base ◽  
Stone Disease ◽  
Significant Morbidity ◽  
Renal Stone Disease

Renal stone disease is a worldwide problem which carries significant morbidity. It frequently requires specialist urology intervention. Patients with recurrent disease and those at high risk require specialist investigations and review. Certain cases benefit from medical and surgical intervention. In this review, we discuss the pathophysiology, risk assessment, specialist investigations and various interventions, their rationale and evidence base. This review aims to provide an update of the previous publication in 2001 in this journal on this topic.

Watchful waiting for stone disease

2017 ◽  
Author(s):  
John Reynard ◽  
Ben Turney
Keyword(s):  
Natural History ◽  
Predictive Power ◽  
Renal Stones ◽  
Stone Disease ◽  
Stone Size ◽  
Number Of Patients ◽  
Natural History Studies ◽  
Stone Migration ◽  
History Of ◽  
Ureteric Colic

Renal stones are highly prevalent and while many cause symptoms or are of a size that requires treatment even if asymptomatic, the natural history of stones suggests that treatment may not be necessary in all cases. Stone size, position, and number are related, to a degree, to the likelihood of a subsequent stone event such as stone migration causing ureteric colic or increase in stone size, but the predictive power of ‘natural history’ studies is limited by the small number of patients in these studies. In this chapter, the evidence for watchful and waiting for asymptomatic stone disease is explored, and situations in which it is reasonable and conversely unreasonable are discussed.

scholarly journals Composition of Renal Stone– An experience at Armed Forces Institute of Pathology

2016 ◽  
Vol 12 (2) ◽  
pp. 21-25
Author(s):  
Lubna Naznin ◽  
Debashish Saha ◽  
Md Jahangir Chowdhury ◽  
Yasmin Akter ◽  
Most Sarmin Sultana ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Renal Stone ◽  
Colorimetric Method ◽  
Ammonium Phosphate ◽  
Armed Forces ◽  
Renal Stones ◽  
Stone Disease ◽  
Urinary Stones ◽  
Female Ratio ◽  
Renal Stone Disease

Introduction: In Asia the stone belt has been reported to stretch across our neighbouring countries Pakistan, India, Myanmar etc signifies a higher incidence of renal stone disease in Bangladesh. Objective: To determine the pattern of chemical composition of renal stones by semi-quantitative technique in patients presented to Armed Forces Institute of Pathology (AFIP) and to evaluate the predominant constituent present in them. Materials and Methods: This descriptive study was conducted at Armed Forces Institute of Pathology (AFIP), Chemical pathology department from October 2013 to October 2014. Renal stones of 37 Urolithiasis patients were analyzed chemically, using DiaSys analysis kit, employing titrimetric method for estimation of calcium and colorimetric method for Oxalate, Ammonium, Phosphate, Magnesium, Uric Acid and Cystine. Concentration of each individual component then was expressed in percentage and used to interpret renal stone composition using the calculation scale. Results: Males were more prone to renal stone disease, having male to female ratio 5.2:1. Urinary stones occur in all age groups, in this study age ranged from 4 to 72 years with mean age 38.8±16.0 years and mostly affected was the working age group 21 to 50 years (70.2%). Mixed components (i.e. mixed stone) rather than a single component was the commonest type constituting 83.8% of all renal stones. The commonest mixed stone found was Calcium Oxalate with Apatite (41.9 %). Pure Calcium Oxalate was the 2nd most common (10.8%) variant followed by Struvite stones (5.4%). Cystine and Brushite were the least common renal stones in this study. Conclusion: Calcium Oxalate was the most predominant chemical component in renal stones (94.6%). More research is needed to assess the frequency, types, and correlation of renal stones with environmental, dietary and genetic factors in Bangladesh. Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 21-25

Bone Mineral Content in Idiopathic Renal Stone Disease and in Primary Hyperparathyroidism

1983 ◽  
Vol 9 (1) ◽  
pp. 32-34 ◽  
Author(s):  
Michel Fuss ◽  
Clémentine Gillet ◽  
Jacques Simon ◽  
Jean-Claude Vandewalle ◽  
André Schoutens ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Renal Stone ◽  
Stone Disease ◽  
Renal Stone Disease

Recurrence and Family History of Renal Stone Disease

2015 ◽  
pp. 30-33 ◽  
Author(s):  
A. Trinchieri ◽  
A. Mandressi ◽  
P. Luongo ◽  
L. Mazza ◽  
C. Zaatar ◽  
...  
Keyword(s):  
Family History ◽  
Renal Stone ◽  
Stone Disease ◽  
Renal Stone Disease ◽  
History Of

scholarly journals Progressive Bilateral Childhood Urolithiasis of Rare Etiology: Ultrasound Images and Evidence-Based Therapeutic Recommendations.

2021 ◽  
pp. 1-5
Keyword(s):  
Renal Stone ◽  
Renal Stones ◽  
Stone Disease ◽  
Evidence Based ◽  
Ultrasound Images ◽  
Rare Presentation ◽  
Renal Stone Disease ◽  
Urinary Infections ◽  
Medical Therapies ◽  
Infective Etiology

Background: Multiple, recurrent and bilateral renal stones causing progressive bilateral urolithiasis is rare during childhood and metabolic disorder such as cystinuria and oxalosis are commonly. The aim of this paper is to report the very rare presentation of hypercalciuria and hypercalciuria with progressive bilateral renal stone disease, with stones predominantly composed of ammonium and phosphate suggesting infective etiology. Patients and methods: A boy with progressive bilateral renal stone disease since early infancy and had been treated by several urologist during the previous three years was studied. He was first referred at the age of five years requesting the opinion about the use of medical therapies and therefore an evidence-based recommendation was made. Results: The boy was initially diagnosed as having bilateral urolithiasis at about the age of two years and during the previous three years with three surgical operations and two lithotripsy sessions. Stone were predominantly composed of ammonium (++++) and phosphate (++++), but they also contained calcium (+++) and uric acid (+). There was evidence of urinary infections with Klebsiella and Enterobacter species suggesting an infective etiology of the stone disease. On referral, Sodium nitroprusside test for cystine was negative and paper chromatography for cystine was also negative. 24-hour urine examination (volume 1600 ml): Calcium 264 mg/24 hr (more than 12 mg/kg/24hr) and oxalate 0.17 g/24 hr (Normal: 0.01-0.04 g /24). Conclusion: Urologists should make an early consultation with a pediatrician expert in renal disorders to provide the necessary medical therapies. Bilateral progressive renal stone disease is rarely caused by infective etiologies alone and the presence of recurrent urinary infections should not lead to ignoring the possibility of metabolic abnormalities.

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