ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model

1998 ◽  
Vol 47 (10) ◽  
pp. 375-383 ◽  
Author(s):  
T. Horizoe ◽  
N. Nagakura ◽  
K. Chiba ◽  
H. Shirota ◽  
M. Shinoda ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Inflammatory Activity ◽  
Cyclooxygenase Inhibitor ◽  
Inflammation Model ◽  
Anti Inflammatory

scholarly journals Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice

Medicines ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. 65 ◽  
Author(s):  
Rosa Direito ◽  
João Rocha ◽  
Ana Lima ◽  
Maria Margarida Gonçalves ◽  
Maria Paula Duarte ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Colon Injury ◽  
Mentha Spicata ◽  
Inflammation Model ◽  
Bowel Diseases ◽  
Phenolic Extract ◽  
Anti Inflammatory ◽  
Ht 29

Background: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused on the essential oil suggesting an anti-inflammatory activity. This work aimed to perform a preliminary screening of the in vivo anti-inflammatory effects of a spearmint phenolic extract in an acute inflammation model, in a chronic inflammation model of colitis, and also study the effects in vitro on a colon cancer model. Methods: Spearmint extract was administered to rats of a paw oedema model (induced by carrageenan) and to mice from a TNBS-induced colitis model in parallel with studies using HT-29 CRC cells. Results: Administration of the extract led to reduced paw inflammation, reduction of colon injury and inflammation, with attenuation of histological markers, and reduction of iNOS expression. It repressed the in vitro movement of HT-29 cells in a wound healing assay. Conclusions: These findings suggest that spearmint extract exhibits acute and chronic anti-inflammatory activity and is able to inhibit migration of cancer cells, suggesting a potential role in the supplementary therapy of IBD patients.

scholarly journals Effects of Flavonoids from French Marigold (Florets ofTagetes patulaL.) on Acute Inflammation Model

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ken Yasukawa ◽  
Yoshimasa Kasahara
Keyword(s):  
Arachidonic Acid ◽  
Oral Administration ◽  
Topical Application ◽  
Acute Inflammation ◽  
Topical Administration ◽  
Tagetes Patula ◽  
Paw Edema ◽  
Ear Edema ◽  
Inflammation Model ◽  
Anti Inflammatory

The major components patuletin and patulitrin were isolated from French marigold (florets ofTagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

Cellular and Biochemical Characterization of the Anti-Inflammatory Effects of DuP 654 in the Arachidonic Acid Murine Skin Inflammation Model (Part 1 of 2)

1990 ◽  
Vol 3 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Richard R. Harris ◽  
William M. Mackin ◽  
Douglas G. Batt ◽  
Suzanne M. Rakich ◽  
Robert J. Collins ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Biochemical Characterization ◽  
Skin Inflammation ◽  
Inflammation Model ◽  
Anti Inflammatory

scholarly journals In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid

Folia Medica ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 270-274
Author(s):  
Hristina Zlatanova ◽  
Stanislava Vladimirova ◽  
Ilia Kostadinov ◽  
Atanas T. Bijev
Keyword(s):  
Chronic Inflammation ◽  
Butyric Acid ◽  
Inflammatory Activity ◽  
Control Group ◽  
Paw Edema ◽  
In Vivo Evaluation ◽  
Continuous Administration ◽  
Inflammation Model ◽  
Anti Inflammatory ◽  
Acid Compound

Abstract Background: Persisting inflammatory stimuli cause chronic inflammation recognized as the major factor contributing to the development of a number of diseases. One group of drugs used in the treatment of chronic inflammation is the group of non-steroidal anti-inflammatory drugs and, more specifically, the selective COX-2 inhibitors (coxibs). However, most of the coxibs were withdrawn from the market in view of their safety profile. In the present study, 2-[3-Acetyl-5-(4-chlorophenyl)- 2-methyl-pyrrol-1-yl]-4-methylsulfanyl-butyric acid (compound 3e), an Npyrrolylcarboxylic acid derivative structurally related to celecoxib, is evaluated for anti-inflammatory activity after single and multiple (14 days) administration using an animal inflammation model. Aim: To evaluate the anti-inflammatory properties of 2-[3-Acetyl-5-(4-chlorophenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanyl-butyric acid (compound 3e) after single and multiple (14 days) administration using an animal inflammation model. Materials and methods: Forty Wistar rats were allocated into 5 groups (n=8) treated with saline (controls), diclofenac (25 mg/kg b.w.), compound 3e (10, 20 and 40 mg/kg b.w.) intraperitoneally. The volume of the right hind paw of the animals of all groups is measured prior to treatment and two, three and four hours after administration of carrageenan using a plethysmometer (Ugo Basile, Italy). The percentage of paw edema is calculated using the Trinus formula. Results: In a single administration, compound 3e in doses of 10 and 20 mg/kg b.w. did not inhibit paw edema, while a dose of 40 mg/kg b.w. significantly inhibited carrageenan-induced paw edema at 2 hours in comparison with the control group. After continuous administration, compound 3e in doses of 10, 20 and 40 mg/kg b.w. significantly reduced paw edema at 2, 3, and 4 hours compared to animals treated with saline. Conclusions: Compound 3e shows anti-inflammatory properties similar to those of diclofenac after continuous administration.

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