acid compound
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2022 ◽  
Vol 71 (1) ◽  
pp. 127-134
Author(s):  
Maulidiyah Maulidiyah ◽  
Akhmad Darmawan ◽  
Wahyu Wahyu ◽  
Andi Musdalifah ◽  
La Ode Agus Salim ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7556
Author(s):  
Shengsheng Lu ◽  
Jianan Hu ◽  
Xi Xie ◽  
Runhong Zhou ◽  
Fangfang Li ◽  
...  

A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), ethyl homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture broth of Streptomyces sp. BM-8, an actinobacterial strain isolated from the feces of Equus quagga. The structures of these compounds were established by analyses of spectroscopic data, including 1D and 2D nuclear magnetic resonance spectra (NMR), as well as by HR-ESI-MS spectrometry and chemical derivative analyses. Additionally, a serial analogue of nonactic acid and homononacticacid (8–21) was synthesized. The cytotoxicity of 1–21 wastested against a panel of cancer cell lines, such as HT-29, MCF-7, A375 and K562, with MTT assay. In addition, the cytotoxicity tests revealed that 1 was less cytotoxic toward a panel of cancerous cells, as compared with valinomycin (6).


Author(s):  
Maulidiyah Maulidiyah ◽  
Muhammad Natsir ◽  
Wa Nazila ◽  
Andi Musdalifah ◽  
La Ode Agus Salim ◽  
...  

2021 ◽  
Vol 2076 (1) ◽  
pp. 012031
Author(s):  
Ya Zhang ◽  
Yuyi Wang ◽  
Wen Nie ◽  
Han Zheng ◽  
Qihao Wang ◽  
...  

Abstract The magnetic chitosan-stearic acid compound was prepared for using chitosan and stearic acid. The morphology, structure and hydrophobic property of the magnetic chitosan-stearic acid compound were characterized. The influences of oil type and temperature on its oil absorption performance were determined. The results shows that the magnetic chitosan-stearic acid compound has a fluffy structure with a contact angle of 133.65°, indicating that the compound has a good hydrophobic property. Different oils have various impact on the oil absorption performance of the magnetic chitosan-stearic acid compound. The magnetic chitosan-stearic acid compound has the best oil absorption to crude oil, with an oil absorption rate of 4.12 g/g. With the increase of temperature, the oil absorption rate first increases and then decreases. There is an optimal temperature for oil absorption, with a temperature of 40°C.


Author(s):  
A.A. Zubenko ◽  
L.N. Fetisov ◽  
K.N. Kononenko ◽  
A.E. Svyatogorova

The aim of the present work is to synthesize phenoxypyridine derivatives and to screen substances with a high level of biological activity within the series of synthesized compounds, which is essential for solving the problem of overcoming the growing drug resistance of bacteria and protozoa. The interaction of 2-chloro-5-nitro- and 2-chloro-3-nitro-pyridine with aromatic aldehydes containing phenolic hydroxyl gave 15 pyridine series aryl ethers in high yields when reacted in dimethylformamide (DMFA) or dimethyl sulfoxide (DMSO) in the presence of bases. In the reaction we used phenolic derivative of kojic acid (compound 1 of Table 1), a number of benzene series aldehydes with different substituents: 3-methoxy-4-hydroxybenzaldehyde (compound 2 of Table 1), 4-hydroxybenzaldehyde (compound 3 of Table 1), 2,4-dihydroxybenzaldehyde (compound 5 of Table 1), 3-methoxy-4-hydroxybenzaldehyde (compound 7 of Table 1 ), salicylic aldehyde (compound 11 of Table 1), 3,4-dihydroxybenzaldehyde (compound 12 of Table 1), vanillin (compound 13 of Table 1), and compound 15 (Table 1) of the benzene series with two hydroxyl and aldehyde groups. As well as benzene-type aldehydes, the methyl ester of salicylic acid (compound 4 of Table 1), 4-hydroxymethylphenol (compound 6 of Table 1), 4-acetylphenol (compound 8 of Table 1), and 3-hydroxy benzoic acid (compound 14 of Table 1) were used. In the reaction, in addition to the above compounds, 7-hydroxycoumarin (compound 9 of Table 1) and semicarbazide-4-hydroxybenzaldehyde (compound 10 of Table 1) were also used. Their purification was performed by recrystallization from organic solvents (ethyl acetate, benzene, ethanol, and isopropanol). The obtained compounds were studied as part of the institute's search for compounds to expand the range of active substances with protistoсid and antibacterial activity with low toxicity. Synthesized compounds have pronounced antiprotozoal activity against Colpoda steinii. the most active compound contains a nitro group in the 3rd position of the pyridine ring as well as an aldehyde and hydroxyl group in the benzene ring. The minimum protistocidal concentration of this compound is 0.9 µg/ml, which is 60 fold more active than toltrazuril and 8 fold more active than chloroquine. This compound is recommended for extended toxicological and pharmacological studies.


Author(s):  
L.N. Fetisov ◽  
A.A. Zubenko ◽  
K.N. Kononenko ◽  
A. E. Svyatogorova

By reaction of pyridine nitro derivatives containing a mobile halogen atom with thiols of the benzene series, twelve thioaryl ethers of nitropyridine were obtained. However, 2-chloro-3-nitropyridine and 2-chloro-5-nitropyridine were used as reactive pyridine compounds. The reaction was carried out in dimethylformamide (DMFA) or dimethyl sulfoxide (DMSO) in the presence of bases: sodium ethylate, potash, sodium hydride. Generally, the yields exceeded 90%. The sulfur containing derivatives of aromatic series were 2-mercaptobenzoic acid (compound 1 of Table 1), methyl ester of 2-mercaptobenzoic acid (compounds 2 and 3 of Table 1), compound 3 being obtained by reduction of nitro group of compound 2. Also the amides of 2-mercaptobenzoic acid were used: 3-dimethylaminopropylamide of 2-mercaptobenzoic acid (compound 4 of Table 1), and also the reduction product of compound 4 to 3-aminopyridine derivative (compound 5 of Table 1) and morfolide of 2-mercaptobenzoic acid (compound 6 of Table 1). To make the water-soluble a sodium salt of 2-mercaptobenzoic acid was obtained (compound 7 of Table 1). A number of compounds with the pyridine ring nitrogroup reduced to amine (compounds 8, 10 of Table 1), as well as a number of derivatives containing both free (compounds 9, 10 of Table 1) and acylated amino group (compound 11 of Table 1) were also obtained. We also prepared compound 12 representing a product of interaction of 2-chloro-3-nitropyridine with 2-mercapto-3-acetylpyridine. We should note that the best nitrogroup reductant for the synthesis of compounds 3, 5, 7, and 10 is powdered iron in alcohol medium containing both inorganic and organic acids (hydrochloric or acetic acid). The application of other reducing agents (sodium sulfide and ammonium sulfide) led to strong resinification of the reaction mixture. The compounds were recrystallized from organic solvents (ethyl acetate, benzene, ethanol) for purification. Significant antiprotozoic activity was found in 7 of 12 compounds (58%), with 3-nitro-2-chloropyridine being the most active (7.8 and 3.9 ?g/ml). To enhance the activity, the synthesis of compounds with an amino group in the benzene ring as well as the introduction of both donor and acceptor substituents into the benzene ring is recommended.


BioResources ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 5901-5914
Author(s):  
Minjay Chung ◽  
Sensung Cheng ◽  
Chunya Lin ◽  
Shangtzen Chang

This study focuses on volatile aromatic constituents extracted using solid-phase microextraction (SPME) from underground and aboveground Bambusa oldhamii shoots. Analysis was conducted using the extracts after heating at various temperatures and for various durations. Results of gas chromatography-mass spectrometry (GC-MS) revealed six SPME-extracted volatile aromatic compounds in underground B. oldhamii shoots and eleven in aboveground B. oldhamii shoots. Methyl salicylate with a characteristic mint aroma and methoxy-phenyl oxime that gives a smell of fresh shrimp and crabs are the main volatile compounds found in underground and aboveground shoots of B. oldhamii, respectively. Moreover, the two types of shoots tested also contain volatile compounds including fatty acids: n-hexadecanoic acid (27.94%) and aliphatic aldehyde: trans-2-nonenal (16.31%), respectively. The GC-MS analysis of underground and aboveground B. oldhamii shoots steamed at 100 C for 60 min revealed n-hexadecanoic acid as the main fatty acid compound.


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