Arachidonic acid peroxidation in inflammation and its inhibition as a mechanism for anti-inflammatory activity

1980 ◽  
pp. 115-127 ◽  
Author(s):  
G. Higgs ◽  
K. Eakins
Keyword(s):  
Arachidonic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model

1998 ◽  
Vol 47 (10) ◽  
pp. 375-383 ◽  
Author(s):  
T. Horizoe ◽  
N. Nagakura ◽  
K. Chiba ◽  
H. Shirota ◽  
M. Shinoda ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Inflammatory Activity ◽  
Cyclooxygenase Inhibitor ◽  
Inflammation Model ◽  
Anti Inflammatory

Anti-Inflammatory Activity of Croconazole, a Broad-Spectrum Antimycotic Agent, in the Arachidonic Acid-Induced Mouse Ear Swelling Test

1995 ◽  
Vol 8 (4) ◽  
pp. 211-214 ◽  
Author(s):  
Dierk Steinmann ◽  
Joachim Barth ◽  
Gottfried Wozel
Keyword(s):  
Arachidonic Acid ◽  
Broad Spectrum ◽  
Inflammatory Activity ◽  
Mouse Ear ◽  
Antimycotic Agent ◽  
Anti Inflammatory

Study of Three Sesquiterpene Lactones fromTithonia diversifoliaon their Anti-Inflammatory Activity Using the Transcription Factor NF-κB and Enzymes of the Arachidonic Acid Pathway as Targets

Planta Medica ◽  
1998 ◽  
Vol 64 (07) ◽  
pp. 588-593 ◽  
Author(s):  
Peter Rüngeler ◽  
Guido Lyß ◽  
Victor Castro ◽  
Gerardo Mora ◽  
Heike Pahl ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Arachidonic Acid ◽  
Sesquiterpene Lactones ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions

1995 ◽  
Vol 351 (3) ◽  
Author(s):  
Gloria Bustos ◽  
MariaLuisa Ferr�ndiz ◽  
MariaJes�s Sanz ◽  
Miguel Pay� ◽  
MariaJos� Alcaraz
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Arachidonic Acid Metabolism ◽  
Inflammatory Activity ◽  
The Novel ◽  
Inflammatory Agent ◽  
Anti Inflammatory

Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids

1991 ◽  
Vol 32 (3-4) ◽  
pp. 283-288 ◽  
Author(s):  
M. L. Ferrándiz ◽  
M. J. Alcaraz
Keyword(s):  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Arachidonic Acid Metabolism ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

Inflammation ◽  
2015 ◽  
Vol 38 (4) ◽  
pp. 1639-1648 ◽  
Author(s):  
Chunfeng Xie ◽  
Xiaoting Li ◽  
Jieshu Wu ◽  
Zhaofeng Liang ◽  
Feifei Deng ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Phospholipase A2 ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway ◽  
Magnesium Isoglycyrrhizinate

scholarly journals Study of In silico Anti-Inflammatory Potential of Tyramine-Fe complex in Brotowali Plants

2020 ◽  
Author(s):  
T.W. Wimbuh ◽  
B.S. Sutiman ◽  
Sri Widyarti ◽  
H. S Djoko
Keyword(s):  
Arachidonic Acid ◽  
In Silico ◽  
Docking Simulation ◽  
Inflammatory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fe Complex

AbstractTyramine-Fe complex is a bioinorganic complex that is formed in brotowali. The complex is thought to play a role in the anti-inflammatory activity of brotowali. The mechanism of anti-inflammatory drugs such as aspirin and ibuprofen is to inhibit the reaction of prostaglandin formation from COX2 and arachidonic acid. In this study, a docking simulation was performed between COX2 with single tyramine, tyramine-Fe complex ibuprofen, and aspirin. The results showed that the COX2-single tyramine bond overlapped with COX2-aspirin, while COX2-tyramine-Fe complex bond overlapped with COX2-ibuprofen. The energy required to form COX2-tyramine-Fe complex bond was smaller than that of single tyramine, aspirin, and ibuprofen. The number of bonds of COX2-tyramine-Fe complex bond is higher than that of single tyramine. These results proved that COX2-tyramine-Fe complex bond had anti-inflammatory activity and greater activity than single tyramine.

Sign in / Sign up

Export Citation Format

Share Document