Role of the inositol 1,4,5-trisphosphate receptor in early embryonic development

1999 ◽  
Vol 56 (3-4) ◽  
pp. 296-304 ◽  
Author(s):  
S. Kume
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca2+signaling

2010 ◽  
Vol 3 (6) ◽  
pp. 530-532 ◽  
Author(s):  
Eva Sammels ◽  
Benoit Devogelaere ◽  
Djalila Mekahli ◽  
Geert Bultyncki ◽  
Ludwig Missiaen ◽  
...  
Keyword(s):  
Receptor Interaction ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

122 Role of calmodulin on the calcium-dependent regulation of the inositol 1,4,5-trisphosphate receptor

1996 ◽  
Vol 25 ◽  
pp. S24
Author(s):  
Takayuki Michikawa ◽  
Junji Hirota ◽  
Seiko Kawano ◽  
Masayasu Hiraoka ◽  
Teiichi Furuichi ◽  
...  
Keyword(s):  
Calcium Dependent ◽  
Inositol 1,4,5 Trisphosphate ◽  
Trisphosphate Receptor

scholarly journals Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Mohamed Ashry ◽  
Sandeep K. Rajput ◽  
Joseph K. Folger ◽  
Jason G. Knott ◽  
Nabil A. Hemeida ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Functional Role ◽  
Akt Signaling ◽  
Early Embryonic Development ◽  
Development Potential ◽  
Potential Link

scholarly journals The role of apoptosis in early embryonic development of the adenohypophysis in rats

2008 ◽  
Vol 4 (1) ◽  
Author(s):  
Jens Weingärtner ◽  
Kristina Lotz ◽  
Andreas Faltermeier ◽  
Oliver Driemel ◽  
Johannes Kleinheinz ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development

scholarly journals Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†

2020 ◽  
Vol 102 (4) ◽  
pp. 795-805 ◽  
Author(s):  
Sandeep K Rajput ◽  
Chunyan Yang ◽  
Mohamed Ashry ◽  
Joseph K Folger ◽  
Jason G Knott ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Bone Morphogenetic Proteins ◽  
Mammalian Species ◽  
Cell Lineage ◽  
Bmp Signaling ◽  
Early Embryonic Development ◽  
Protein Signaling ◽  
Bovine Embryos ◽  
Embryonic Genome

Abstract Characterization of the molecular factors regulating early embryonic development and their functional mechanisms is critical for understanding the causes of early pregnancy loss in monotocous species (cattle, human). We previously characterized a stage specific functional role of follistatin, a TGF-beta superfamily binding protein, in promoting early embryonic development in cattle. The mechanism by which follistatin mediates this embryotropic effect is not precisely known as follistatin actions in cattle embryos are independent of its classically known activin inhibition activity. Apart from activin, follistatin is known to bind and modulate the activity of the bone morphogenetic proteins (BMPs), which signal through SMAD1/5 pathway and regulate several aspects of early embryogenesis in other mammalian species. Present study was designed to characterize the activity and functional requirement of BMP signaling during bovine early embryonic development and to investigate if follistatin involves BMP signaling for its stage specific embryotropic actions. Immunostaining and western blot analysis demonstrated that SMAD1/5 signaling is activated after embryonic genome activation in bovine embryos. However, days 1–3 follistatin treatment reduced the abundance of phosphorylated SMAD1/5 in cultured embryos. Inhibition of active SMAD1/5 signaling (8–16 cell to blastocyst) using pharmacological inhibitors and/or lentiviral-mediated inhibitory SMAD6 overexpression showed that SMAD1/5 signaling is required for blastocyst production, first cell lineage determination as well as mRNA and protein regulation of TE (CDX2) cell markers. SMAD1/5 signaling was also found to be essential for embryotropic actions of follistatin during days 4–7 but not days 1–3 of embryo development suggesting a role for follistatin in regulation of SMAD1/5 signaling in bovine embryos.

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