Design, synthesis, and QSAR study of novel 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N-phenylacetamide derivatives as cytotoxic agents

2010 ◽  
Vol 20 (5) ◽  
pp. 615-625 ◽  
Author(s):  
Neha R. Modi ◽  
Ravi J. Shah ◽  
Manish J. Patel ◽  
Maulik Suthar ◽  
Bhupendrasinh F. Chauhan ◽  
...  
Keyword(s):  
Cytotoxic Agents ◽  
Qsar Study ◽  
Design Synthesis

Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

2017 ◽  
Vol 126 ◽  
pp. 853-869 ◽  
Author(s):  
Md Jawaid Akhtar ◽  
Anees Ahmad Siddiqui ◽  
Ahsan Ahmed Khan ◽  
Zulphikar Ali ◽  
Rikeshwer Prasad Dewangan ◽  
...  
Keyword(s):  
Cytotoxic Agents ◽  
Qsar Study ◽  
Design Synthesis ◽  
Erbb2 Receptor

scholarly journals Discovery of pyrano[2,3-d]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4454-4464
Author(s):  
Nour E. A. Abd El-sattar ◽  
Eman H. K. Badawy ◽  
Eman Z. Elrazaz ◽  
Nasser S. M. Ismail
Keyword(s):  
Cell Death ◽  
Dna Repair ◽  
Antitumor Activity ◽  
Cancer Cell ◽  
Cytotoxic Agents ◽  
Repair Mechanism ◽  
Design Synthesis ◽  
Parp 1

PARP-1 are involved in DNA repair damage and so PARP-1 inhibitors have been used as potentiators in combination with DNA damaging cytotoxic agents to compromise the cancer cell DNA repair mechanism, resulting in genomic dysfunction and cell death.

Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: design, synthesis and evaluation as potential cytotoxic agents

2021 ◽  
pp. 131222
Author(s):  
Jyoti Mareddy ◽  
Kazi Amirul Hossain ◽  
N. Sudhakar Yadav ◽  
Venkanna Banothu ◽  
Jaya Shree Anireddy ◽  
...  
Keyword(s):  
Triazole Ring ◽  
Structural Features ◽  
Cytotoxic Agents ◽  
Design Synthesis

scholarly journals Design, synthesis and QSAR study of 2′-hydroxy-4′-alkoxy chalcone derivatives that exert cytotoxic activity by the mitochondrial apoptotic pathway

2019 ◽  
Vol 27 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Silvia Marquina ◽  
Maritza Maldonado-Santiago ◽  
Jessica Nayelli Sánchez-Carranza ◽  
Mayra Antúnez-Mojica ◽  
Leticia González-Maya ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Qsar Study ◽  
Apoptotic Pathway ◽  
Design Synthesis ◽  
Mitochondrial Apoptotic Pathway ◽  
Chalcone Derivatives
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