Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury

2006 ◽  
Vol 32 (11) ◽  
pp. 1889-1894 ◽  
Author(s):  
Jean-Christophe Richard ◽  
Didier Le Bars ◽  
Nicolas Costes ◽  
Fabienne Bregeon ◽  
Christian Tourvieille ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Alveolar Recruitment ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Mechanical Power Correlates With Lung Inflammation Assessed by Positron-Emission Tomography in Experimental Acute Lung Injury in Pigs

2021 ◽  
Vol 12 ◽  
Author(s):  
Martin Scharffenberg ◽  
Jakob Wittenstein ◽  
Xi Ran ◽  
Yingying Zhang ◽  
Anja Braune ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Uptake Rate ◽  
Emission Tomography ◽  
Mechanical Power ◽  
Relative Mass ◽  
Neutrophilic Inflammation ◽  
Positron Emission ◽  
Pet Ct

Background: Mechanical ventilation (MV) may initiate or worsen lung injury, so-called ventilator-induced lung injury (VILI). Although different mechanisms of VILI have been identified, research mainly focused on single ventilator parameters. The mechanical power (MP) summarizes the potentially damaging effects of different parameters in one single variable and has been shown to be associated with lung damage. However, to date, the association of MP with pulmonary neutrophilic inflammation, as assessed by positron-emission tomography (PET), has not been prospectively investigated in a model of clinically relevant ventilation settings yet. We hypothesized that the degree of neutrophilic inflammation correlates with MP.Methods: Eight female juvenile pigs were anesthetized and mechanically ventilated. Lung injury was induced by repetitive lung lavages followed by initial PET and computed tomography (CT) scans. Animals were then ventilated according to the acute respiratory distress syndrome (ARDS) network recommendations, using the lowest combinations of positive end-expiratory pressure and inspiratory oxygen fraction that allowed adequate oxygenation. Ventilator settings were checked and adjusted hourly. Physiological measurements were conducted every 6 h. Lung imaging was repeated 24 h after first PET/CT before animals were killed. Pulmonary neutrophilic inflammation was assessed by normalized uptake rate of 2-deoxy-2-[18F]fluoro-D-glucose (KiS), and its difference between the two PET/CT was calculated (ΔKiS). Lung aeration was assessed by lung CT scan. MP was calculated from the recorded pressure–volume curve. Statistics included the Wilcoxon tests and non-parametric Spearman correlation.Results: Normalized 18F-FDG uptake rate increased significantly from first to second PET/CT (p = 0.012). ΔKiS significantly correlated with median MP (ρ = 0.738, p = 0.037) and its elastic and resistive components, but neither with median peak, plateau, end-expiratory, driving, and transpulmonary driving pressures, nor respiratory rate (RR), elastance, or resistance. Lung mass and volume significantly decreased, whereas relative mass of hyper-aerated lung compartment increased after 24 h (p = 0.012, p = 0.036, and p = 0.025, respectively). Resistance and PaCO2 were significantly higher (p = 0.012 and p = 0.017, respectively), whereas RR, end-expiratory pressure, and MP were lower at 18 h compared to start of intervention.Conclusions: In this model of experimental acute lung injury in pigs, pulmonary neutrophilic inflammation evaluated by PET/CT increased after 24 h of MV, and correlated with MP.

scholarly journals POSITRON EMISSION TOMOGRAPHY (PET) OF 18FDG UPTAKE IS AN ACCURATE IN VIVO MEASURE OF NEONATAL ACUTE LUNG INJURY † 1316

1996 ◽  
Vol 39 ◽  
pp. 222-222
Author(s):  
Haresh Kirpalani ◽  
Kabir Abubakar ◽  
Claude Nahmias ◽  
Derek deSa ◽  
Geoffrey Coates ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Emission Tomography ◽  
Positron Emission ◽  
18Fdg Uptake

Modeling kinetics of infused 13NN-saline in acute lung injury

2003 ◽  
Vol 95 (6) ◽  
pp. 2471-2484 ◽  
Author(s):  
K. O'Neill ◽  
J. G. Venegas ◽  
T. Richter ◽  
R. S. Harris ◽  
J. D. H. Layfield ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Volume Of Distribution ◽  
Model Fit ◽  
Emission Tomography ◽  
Central Venous ◽  
Blood Concentrations ◽  
Positron Emission ◽  
Gas Volume ◽  
Kinetics Of

A mathematical model was developed to estimate right-to-left shunt (Fs) and the volume of distribution of 13NN in alveolar gas (VA) and shunt tissue (Vs). The data obtained from this model are complementary to, and obtained simultaneously with, pulmonary functional positron emission tomography (PET). The model describes 13NN kinetics in four compartments: central mixing volume, gas-exchanging lung, shunting compartment, and systemic recirculation. To validate the model, five normal prone (NP) and six surfactant-depleted sheep in the supine (LS) and prone (LP) positions were studied under general anesthesia. A central venous bolus of 13NN-labeled saline was injected at the onset of apnea as PET imaging and arterial 13NN sampling were initiated. The model fit the tracer kinetics well (mean r2 = 0.93). Monte Carlo simulations showed that parameters could be accurately identified in the presence of expected experimental noise. Fs derived from the model correlated well with shunt estimates derived from O2 blood concentrations and from PET images. Fs was higher for LS (54 ± 18%) than for LP (5 ± 4%) and NP (1 ± 1%, P < 0.01). VA, as a fraction of PET-measured lung gas volume, was lower for LS (0.18 ± 0.09) than for LP (0.96 ± 0.28, P < 0.01), whereas Vs, as a fraction of PET-measured lung tissue volume, was higher for LS (0.46 ± 0.26) than for LP (0.05 ± 0.08, P < 0.01). The main conclusions are as follows: 1) the model accurately describes measured arterial 13NN kinetics and provides estimates of Fs, and 2) in this animal model of acute lung injury, the fraction of available gas volume participating in gas exchange is reduced in the supine position.

Fluoro-D-glucose-micro positron emission tomography as a diagnostic tool to confirm brain death in a murine donor lung injury model

2013 ◽  
Vol 180 (2) ◽  
pp. 343-348 ◽  
Author(s):  
Shana Wauters ◽  
Michel Koole ◽  
Peter Vermaelen ◽  
Jana Somers ◽  
Koen Van Laere ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Lung Injury ◽  
Brain Death ◽  
Diagnostic Tool ◽  
Emission Tomography ◽  
Positron Emission ◽  
Injury Model ◽  
Donor Lung ◽  
Lung Injury Model

Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury

2002 ◽  
Vol 93 (6) ◽  
pp. 2181-2191 ◽  
Author(s):  
J. C. Richard ◽  
M. Janier ◽  
F. Lavenne ◽  
V. Berthier ◽  
D. Lebars ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Positron Emission Tomography ◽  
Oleic Acid ◽  
Lung Injury ◽  
Prone Position ◽  
Supine Position ◽  
Porcine Model ◽  
Emission Tomography ◽  
Almitrine Bismesylate ◽  
Positron Emission

In a porcine model of oleic acid-induced lung injury, the effects of inhaled nitric oxide (iNO) and intravenous almitrine bismesylate (ivALM), which enhances the hypoxic pulmonary vasoconstriction on the distribution of regional pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets [weight of 25 ± 2.6 (SD) kg] were randomly divided into four groups: supine position, prone position, and 10 ppm iNO for 40 min followed by 4 μg · kg−1 · min−1ivALM for 40 min in supine position and in prone position. PBF was measured with positron emission tomography and H2 15O. The redistribution of PBF was studied on a pixel-by-pixel basis. Positron emission tomography scans were performed before and then 120, 160, and 200 min after injury. With prone position alone, although PBF remained prevalent in the dorsal regions it was significantly redistributed toward the ventral regions ( P < 0.001). A ventral redistribution of PBF was also obtained with iNO regardless of the position ( P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.

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