Consideration of growth factors and bio-scaffolds for treatment of combined grade II MCL and ACL injury

Diabetic ulcer has been a challenge to be tackled since there is deficiency of growth factors and impaired immunity, which can lead to amputation if timely intervention is not done. A 59-year-old male patient with a history of uncontrolled diabetes mellitus for 10 years presented with a non-healing foot ulcer since 1year. He was managed with Ayurvedic internal and external medications at OPD level. After 3 months, the outcome was encouraging with complete epithelialization along with improvement in his generalized complaints like lethargy, irregular bowel movements etc.

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Treatment of Grade II Mandibular Furcation Defects by Concentrated Growth Factors and Hydroxyapatite Bone Substitute (Sybograf®): A Case Report

Journal of Health Sciences & Research ◽

10.5005/jp-journals-10042-1071 ◽

2018 ◽

Vol 9 (2) ◽

pp. 61-65

Author(s):

Krishna Kripal ◽

Senthil Rajan ◽

Kavita Chandrasekaran ◽

Thaslim Fathima

Keyword(s):

Case Report ◽

Growth Factors ◽

Bone Substitute ◽

Furcation Defects ◽

Concentrated Growth Factors ◽

Grade Ii

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Immunohistochemical expression of HGF and cMET in meningiomas

QJM ◽

10.1093/qjmed/hcab112.002 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Thanaa E Helal ◽

Faten W Ragheb ◽

Iman H Hewedi ◽

Nermine M Abd Raboh ◽

Mariam I Halim

Keyword(s):

Growth Factors ◽

Targeted Therapy ◽

Tyrosine Kinase Receptors ◽

P Value ◽

Immunohistochemical Expression ◽

Who Grade ◽

Brain Invasion ◽

Prognostic Stratification ◽

Grade Ii ◽

Intracranial Neoplasm

Abstract Background Meningiomas are the most common intracranial neoplasm together with gliomas; but unlike gliomas they are still graded according to their histopathological picture. Many growth factors and tyrosine kinase receptors have been studied in meningiomas in an attempt for prognostic stratification of patients, also to find a suitable targeted therapy for meningiomas. Aim of the study To correlate the immunohistochemical expression of HGF and cMET with the different WHO grades of meningioma in addition to brain invasion. Materials and methods This study included 60 cases of meningiomas (WHO grade I, n = 30 and WHO grade II & III, n = 30), brain invasion was present in 14 cases. Results HGF, cMET & HGF/cMET co-expression were positive in 60.0%, 65.0% and 58.3% respectively of the cases; WHO grade I meningioma showed positivity in 30.0%, 33.3% and 30.0% of the cases respectively in contrast with 90.0%, 96.7% and 86.7% of the cases of WHO grades II & III meningiomas respectively. The relation was statistically highly significant (p- value: <0.001). As regards cases with brain invasion the expression of HGF, cMET and HGF/cMET co-expression was found in 92.9%, 100.0% and 92.9% respectively in comparison with 50.0%, 54.3% and 47.8% in the rest of the cases of meningiomas respectively; the relation was statistically significant (p- value: 0.004). Conclusion The results suggest that HGF/cMET pathway may play a role in the progression of meningiomas from WHO grade I to higher grades II & III.

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Growth factors and the primary cilium in BALB/c 3T3 cells

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100128432 ◽

1987 ◽

Vol 45 ◽

pp. 830-831

Author(s):

R. W. Tucker ◽

N. S. More ◽

S. Jayaraman

Keyword(s):

Growth Factors ◽

Primary Cilium ◽

Cultured Cells ◽

Morphological Changes ◽

Calcium Ionophore ◽

Growth Stimulation ◽

Calcium Ionophore A23187 ◽

Ionophore A23187 ◽

3T3 Cells ◽

Microtubule Depolymerization

The mechanisms by which polypeptide growth factors Induce DNA synthesis in cultured cells is not understood, but morphological changes Induced by growth factors have been used as clues to Intracellular messengers responsible for growth stimulation. One such morphological change has been the transient disappearance of the primary cilium, a “9 + 0” cilium formed by the perinuclear centriole in interphase cells. Since calcium ionophore A23187 also produced both mitogenesis and ciliary changes, microtubule depolymerization might explain ciliary disappearance monitored by indirect immunofluorescence with anti-tubulin antibody. However, complete resorption and subsequent reformation of the primary cilium occurs at mitosis, and might also account for ciliary disappearance induced by growth factors. To settle this issue, we investigated the ultrastructure of the primary cilium using serial thin-section electron microscopy of quiescent BALB/c 3T3 cells before and after stimulation with serum.

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New insights into heparan sulphate biosynthesis from the study of mutant mice

Biochemical Society Symposium ◽

10.1042/bss0690047 ◽

2002 ◽

Vol 69 ◽

pp. 47-57 ◽

Cited By ~ 8

Author(s):

Catherine L. R. Merry ◽

John T. Gallagher

Keyword(s):

Growth Factors ◽

Biosynthetic Pathway ◽

Heparan Sulphate ◽

Mutant Mice ◽

Gene Products ◽

Multiple Gene ◽

Adhesion Proteins ◽

Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

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