Multi-omics analysis reveals metabolism of okadaic acid in gut lumen of rat

2022 ◽  
Author(s):  
Yang Liu ◽  
Yang Lu ◽  
Yu-Hu Jiao ◽  
Da-Wei Li ◽  
Hong-Ye Li ◽  
...  
Keyword(s):  
Okadaic Acid ◽  
Omics Analysis

Analysis of Purified Okadaic Acid and Dinophysis Toxin 1 from Prorocentrum Lima Dodge

2013 ◽  
Vol 40 (4) ◽  
pp. 539-544
Author(s):  
Zhen-Zhou FENG ◽  
Ren-Cheng YU ◽  
Ming-Jiang ZHOU
Keyword(s):  
Okadaic Acid ◽  
Prorocentrum Lima

Multi-Omics Analysis of Respiratory Specimen Characterizes Baseline Molecular Determinants Associated with COVID-19 Diagnosis and Outcome

2020 ◽  
Author(s):  
Jaswinder Singh Maras ◽  
Shvetank Sharma ◽  
Adil Bhat ◽  
sheetalnath Rooge ◽  
Reshu Agarwal ◽  
...  
Keyword(s):  
Respiratory Specimen ◽  
Omics Analysis ◽  
Molecular Determinants

scholarly journals Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp.

2021 ◽  
Vol 10 (10) ◽  
pp. 2100
Author(s):  
Hiroshi Sakagami ◽  
Sachie Nakatani ◽  
Ayame Enomoto ◽  
Sana Ota ◽  
Miku Kaneko ◽  
...  
Keyword(s):  
Culture Medium ◽  
Growth Stimulation ◽  
Pge2 Production ◽  
Oral Diseases ◽  
Total Glutathione ◽  
Simultaneous Treatment ◽  
Alkaline Extract ◽  
Omics Analysis ◽  
Anti Inflammatory ◽  
Inflammatory Action

Efficient utilization of alkaline extracts of several plants for the treatment of oral diseases has been reported. To investigate the mechanism of anti-inflammatory activity of alkaline extract of the leaves of Sasa sp. (SE), multi-omics analysis using metabolomics and DNA array was performed. Human gingival fibroblasts (HGFs) were treated for IL-1β to induce inflammation (detected by PGE2 production in culture medium) in the presence or absence of SE. Both IL-1β and SE showed slight hormetic growth stimulation against HGF. SE inhibited PGE2 production dose- and time-dependently. Its inhibitory action was more pronounced by first treating the cells with SE, rather than with IL-1β. At 3 h after IL-1β treatment, 18 amino acids (except cysteine and glutamic acid), total glutathione (GSH, GSSG, Cys-GSH disulfide), Met-sulfoxide, 5-oxoproline, and SAM declined, whereas DNA expressions of AKT, CASP3, and CXCL3 were elevated. These changes were reversed by simultaneous treatment with SE. The present study suggests that the anti-inflammatory action of SE is mediated via various metabolic pathways for cell survival, apoptosis, and leukocyte recruitment.

Multiple 'omics'-analysis reveals the role of prostaglandin E2 in Hirschsprung's disease

2021 ◽  
Vol 164 ◽  
pp. 390-398
Author(s):  
Weibing Tang ◽  
Minjian Chen ◽  
Xuejiang Guo ◽  
Kun Zhou ◽  
Zechao Wen ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Hirschsprung's Disease ◽  
Hirschsprung’S Disease ◽  
Omics Analysis
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