A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans

1997 ◽  
Vol 72 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Joost DeJongh ◽  
Henk J. M. Verhaar ◽  
Joop L. M. Hermens
Keyword(s):  
Partition Coefficients ◽  
Organic Chemicals ◽  
Property Relationship ◽  
Quantitative Property

Equilibrium distribution of radioxenon in tissue: xenon-hemoglobin association curve

1961 ◽  
Vol 16 (6) ◽  
pp. 1065-1070 ◽  
Author(s):  
Hadley L. Conn
Keyword(s):  
Partition Coefficients ◽  
Equilibrium Distribution ◽  
Hemoglobin Concentration ◽  
Gas Diffusion ◽  
In Vivo Studies ◽  
Diffusion Method ◽  
Body Tissues ◽  
Gas Diffusion Method

In vitro and in vivo studies were made of the equilibrium distribution of radioxenon in various organs and tissues of the dog and the xenon uptake compared with a water standard. Tissue-blood partition coefficients were calculated. The radioxenon-hemoglobin association curve was determined for dog and human hemoglobin and methemoglobin. The uptake of radioxenon by blood, due in particular to xenon-hemoglobin affinity, was appreciably greater than uptake either by water or by most other body tissues. Fat and brain were notable exceptions. Consequently, tissue-blood partition coefficients were about eight for fat, one for brain, and significantly less than one for other tissues studied. Acceptable accuracy for blood flow determinations with a radioxenon inert gas diffusion method would seem to depend on the use of a partition coefficient correction in turn corrected at least for the existing hemoglobin concentration. The uptake of xenon by hemoglobin had the characteristics of a solubility or a quasi-solubility phenomenon. The problem of the nature of the interaction is apparently not resolved. Submitted on June 19, 1961

In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals

2017 ◽  
Vol 36 (7) ◽  
pp. 1934-1946 ◽  
Author(s):  
Yung-Shan Lee ◽  
Justin C. Lo ◽  
S.Victoria Otton ◽  
Margo M. Moore ◽  
Chris J. Kennedy ◽  
...  
Keyword(s):  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
In Vivo Extrapolation

Hydrophobic interaction of organic chemicals with microtubule assembly in vitro

2008 ◽  
Vol 82 (9) ◽  
pp. 601-606 ◽  
Author(s):  
Thomas Stoiber ◽  
Eberhard Unger ◽  
Susanne B. Dorn ◽  
Gisela H. Degen ◽  
Hermann M. Bolt
Keyword(s):  
Hydrophobic Interaction ◽  
Microtubule Assembly ◽  
Organic Chemicals

IN VITRO HEPATIC METABOLISM OF PCBTF: DEVELOPMENT OF Vmax AND Km VALUES AND PARTITION COEFFICIENTS AND THEIR USE IN AN INHALATION PBPK MODEL

1998 ◽  
Vol 10 (1) ◽  
pp. 65-85 ◽  
Author(s):  
B. Knaak James ◽  
W. Smith Ladd ◽  
D. Fitzpatrick Richard ◽  
R. Olson James ◽  
E. Newton Paul
Keyword(s):  
Partition Coefficients ◽  
Pbpk Model ◽  
Hepatic Metabolism

scholarly journals Age-dependent changes in phenytoin tissue bindings in rats: Comparison between in vivo and in vitro tissue-to-blood partition coefficients (Kp values) of phenytoin.

1987 ◽  
Vol 10 (9) ◽  
pp. 470-477 ◽  
Author(s):  
YOSHITERU KATO ◽  
JUNJI HIRATE ◽  
KAZUO SAKAGUCHI ◽  
MASAHARU UENO ◽  
ISAMU HORIKOSHI
Keyword(s):  
Partition Coefficients ◽  
Age Dependent
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