Anandamide and methanandamide induce both vanilloid VR1- and cannabinoid CB1 receptor-mediated changes in heart rate and blood pressure in anaesthetized rats

2001 ◽  
Vol 364 (6) ◽  
pp. 562-569 ◽  
Author(s):  
Barbara Malinowska ◽  
Grzegorz Kwolek ◽  
Manfred Göthert
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Anaesthetized Rats

scholarly journals Methane, a gut bacteria-produced gas, does not affect arterial blood pressure in normotensive anaesthetized rats.

2021 ◽  
Author(s):  
Ewelina Zaorska ◽  
Marta Gawrys-Kopczynska ◽  
Ryszard Ostaszewski ◽  
Dominik Koszelewski ◽  
Marcin Ufnal
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Arterial Blood Pressure ◽  
Acute Administration ◽  
Hemodynamic Effects ◽  
Arterial Blood ◽  
Anaesthetized Rats ◽  
Carbohydrate Fermentation ◽  
Oxidative Effects ◽  
Lines Of Evidence

Methane is produced by carbohydrate fermentation in the gastrointestinal tract through the metabolism of methanogenic microbiota. Several lines of evidence suggest that methane exerts anti-inflammatory, anti-apoptotic and anti-oxidative effects. The effect of methane on cardiovascular system is obscure. The objective of the present study was to evaluate the hemodynamic response to methane. A vehicle or methane-rich saline were administered intravenously or intraperitoneally in normotensive anaesthetized rats. We have found no significant effect of the acute administration of methane-rich saline on arterial blood pressure and heart rate in anaesthetized rats. Our study suggests that methane does not influence the control of arterial blood pressure. However, further chronic studies may be needed to fully understand hemodynamic effects of the gas.

Blocking properties of terguride at the 5-HT2 receptor subtypes mediating cardiovascular responses in the rat

2020 ◽  
Vol 98 (8) ◽  
pp. 511-521
Author(s):  
Oscar Alcántara-Vázquez ◽  
Ma. Trinidad Villamil-Hernández ◽  
Araceli Sánchez-López ◽  
Heinz H. Pertz ◽  
Carlos M. Villalón ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diastolic Blood Pressure ◽  
Receptor Agonist ◽  
Cardiovascular Responses ◽  
Receptor Subtypes ◽  
Pithed Rats ◽  
Anaesthetized Rats ◽  
Dose Dependent

In vitro studies have suggested that terguride blocks the contractile and relaxant responses produced by 5-hydroxytryptamine (5-HT) via 5-HT2A/2B receptors. This study has now investigated terguride’s blocking properties on central/peripheral 5-HT2 receptors in anaesthetized or pithed rats. Male Wistar anaesthetized/pithed rats were cannulated for recording blood pressure and heart rate and for i.v. administration of several compounds. In both groups of rats, i.v. bolus injections of 5-HT or (±)-DOI (a 5-HT2 receptor agonist; 1–1000 μg/kg) produced dose-dependent increases in diastolic blood pressure and heart rate. These responses were dose-dependently antagonized by terguride (10–3000 μg/kg). In anaesthetized rats, i.v. bolus injections of BW723C86 (a 5-HT2B receptor agonist; 1–1000 μg/kg) produced dose-dependent increases in diastolic blood pressure and not dose-dependent increases in heart rate, while in pithed rats, these responses were attenuated. The vasopressor responses elicited by BW723C86 in anaesthetized rats were dose-dependently blocked by terguride (10–300 μg/kg), whereas its the tachycardic responses were dose-independently blocked. These results, taken together, suggest that terguride behaved as an antagonist at the 5-HT2 receptors located in the central nervous system and (or) the systemic vasculature. This is the first evidence demonstrating that terguride can block central/peripheral 5-HT2 receptors mediating cardiovascular responses in anaesthetized or pithed rats.

scholarly journals Reno-Renal and Reno-Adrenal Reflexes in the Rat

1980 ◽  
Vol 59 (s6) ◽  
pp. 323s-325s ◽  
Author(s):  
G. Recordati ◽  
S. Genovesi ◽  
D. Cerati ◽  
R. Di Cintio
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Nervous System ◽  
Renal Artery ◽  
Sympathetic Activity ◽  
Nerve Activity ◽  
Natural Stimuli ◽  
Anaesthetized Rats ◽  
Excitatory Responses

1. Experiments were carried out to investigate whether the activation of renal chemoceptive receptors by natural stimuli might induce reflex alterations of efferent postganglionic activity to the ipsilateral kidney and preganglionic activity to the ipsilateral adrenal. 2. In anaesthetized rats with intact nervous system back-flow of urine and occlusion of the renal artery were accompanied by increments in efferent sympathetic activity both to the kidney and adrenal without concomitant changes in heart rate and blood pressure. 3. Greater excitatory responses in nerve activity to the same test stimuli were observed in rats with the spinal cord cut at C1. 4. These results indicate that the natural activation of renal chemoceptive receptors might induce reno-renal and reno-adrenal excitatory reflexes which are likely to be integrated at spinal and supraspinal levels.

Is Substance P the Transmitter at the First Synapse of the Baroreceptor Reflex in Rats and Cats?

1980 ◽  
Vol 59 (s6) ◽  
pp. 295s-297s ◽  
Author(s):  
G. Haeusler ◽  
R. Osterwalder
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Substance P ◽  
Cardiovascular Effects ◽  
Baroreceptor Reflex ◽  
Solitary Tract ◽  
Anaesthetized Rats ◽  
Contrast Exposure ◽  
Brain Ventricle ◽  
Dose Dependent

1. Substance P, injected into a lateral brain ventricle of urethane-anaesthetized rats, caused dose-dependent increases in blood pressure and heart rate. 2. By contrast, exposure of the obex region of the medulla oblongata to pieces of filter paper soaked in substance P-containing solution resulted in falls of blood pressure and heart rate in both rats and cats. 3. A more precise application of substance P to the first synapse of the baroreceptor reflex by micro-injection into defined areas of the nucleus of the solitary tract also led to an activation of the baroreceptor reflex. 4. Capsaicin, which is known to release substance P from primary afferents, mimicked the sympatho-inhibitory and cardiovascular effects of substance P when applied locally to the nucleus of the solitary tract. 5. The results are compatible with a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflex.

Localization of Central Noradrenergic Mechanisms in Cardiovascular Regulation in Rats

1974 ◽  
Vol 48 (s2) ◽  
pp. 277s-278s ◽  
Author(s):  
H. Struyker Boudier ◽  
G. Smeets ◽  
G. Brouwer ◽  
J. Van Rossum
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Brain Stem ◽  
Cardiovascular Regulation ◽  
Anterior Hypothalamus ◽  
Anaesthetized Rats ◽  
Lower Brain Stem ◽  
The Brain

1. Various drugs were injected stereotactically into the brain of anaesthetized rats. 2. Noradrenaline injected into the area of the nucleus of the tractus solitarius in the lower brain stem or into the far anterior hypothalamus/pre-optic region induced a fall in blood pressure and in heart rate related to the administered dose. 3. When injected into the anterior hypothalamus/pre-optic region, clonidine and alpha-methyl-noradrenaline induced a long-lasting decrease in blood pressure and heart rate.

Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats

1987 ◽  
Vol 140 (3) ◽  
pp. 259-266 ◽  
Author(s):  
Hubert Dabire ◽  
Claudie Cherqui ◽  
Berthe Fournier ◽  
Henri Schmitt
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Anaesthetized Rats
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