Efficacy and safety of atomoxetine for attention-deficit/hyperactivity disorder in children and adolescents—meta-analysis and meta-regression analysis

2007 ◽  
Vol 194 (2) ◽  
pp. 197-209 ◽  
Author(s):  
Jackie Y. W. Cheng ◽  
Ronald Y. L. Chen ◽  
John S. N. Ko ◽  
Emil M. L. Ng
2009 ◽  
Vol 194 (3) ◽  
pp. 204-211 ◽  
Author(s):  
Viktória Simon ◽  
Pál Czobor ◽  
Sára Bálint ◽  
Ágnes Mészáros ◽  
István Bitter

BackgroundIn spite of the growing literature about adult attention-deficit hyperactivity disorder (ADHD), relatively little is known about the prevalence and correlates of this disorder.AimsTo estimate the prevalence of adult ADHD and to identify its demographic correlates using meta-regression analysis.MethodWe used the MEDLINE, PsycLit and EMBASE databases as well as hand-searching to find relevant publications.ResultsThe pooled prevalence of adult ADHD was 2.5% (95% CI 2.1–3.1). Gender and mean age, interacting with each other, were significantly related to prevalence of ADHD. Metaregression analysis indicated that the proportion of participants with ADHD decreased with age when men and women were equally represented in the sample.ConclusionsPrevalence of ADHD in adults declines with age in the general population. We think, however, that the unclear validity of DSM–IV diagnostic criteria for this condition can lead to reduced prevalence rates by underestimation of the prevalence of adult ADHD.


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