MK-801 and amphetamine result in dissociable profiles of cognitive impairment in a rodent paired associates learning task with relevance for schizophrenia

2015 ◽  
Vol 232 (21-22) ◽  
pp. 3911-3920 ◽  
Author(s):  
John Talpos ◽  
Nancy Aerts ◽  
Jason Waddell ◽  
Thomas Steckler
Keyword(s):  
Cognitive Impairment ◽  
Learning Task ◽  
Mk 801 ◽  
Paired Associates

Hippocampal dysfunction in patients with mild cognitive impairment: A functional neuroimaging study of a visuospatial paired associates learning task

2011 ◽  
Vol 49 (7) ◽  
pp. 2060-2070 ◽  
Author(s):  
Mischa de Rover ◽  
Valentino A. Pironti ◽  
Jonathan A. McCabe ◽  
Julio Acosta-Cabronero ◽  
F. Sergio Arana ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Neuroimaging ◽  
Learning Task ◽  
Paired Associates ◽  
Hippocampal Dysfunction ◽  
Neuroimaging Study

scholarly journals The Relationship Between Hearing Loss and Cognitive Impairment in a Chinese Elderly Population: The Baseline Analysis

2021 ◽  
Vol 15 ◽  
Author(s):  
Xinxing Fu ◽  
Bo Liu ◽  
Shuo Wang ◽  
Robert H. Eikelboom ◽  
Dona M. P. Jayakody
Keyword(s):  
Older Adults ◽  
Hearing Loss ◽  
Cognitive Impairment ◽  
Health Care Professionals ◽  
Spatial Working Memory ◽  
Depression Anxiety Stress Scale ◽  
Paired Associates ◽  
Multiple Stepwise Regression Analysis ◽  
Age Related ◽  
Age Related Hearing Loss

Objectives: The objective of the study was to investigate the association between untreated age-related hearing loss and cognitive impairment in Mandarin-speaking older adults living in China.Methods: Older adults (293; 111 males, M = 70.33 ± 4.90 years; 182 females, M = 69.02 ± 4.08 years) were recruited. All participants completed a pure tone audiometric hearing assessment, Hearing Impairment-Montreal Cognitive Assessment Test (HI-MoCA), and a computerized neuropsychology test battery (CANTAB). The Mandarin version of the De Jong Gierveld Loneliness Scale was used to measure the loneliness, and the Mandarin version of the 21-item Depression Anxiety Stress Scale (DASS-21) was used to measure the current severity of a range of symptoms common to depression, stress, and anxiety of the participants.Results: A multiple stepwise regression analysis showed that the average of four mid-frequency thresholds in the better ear was related to CANTAB Paired Associates Learning (β = 0.20, p = 0.002), and the global cognitive function score (HI-MoCA) (β = −0.25, p < 0.001). The average of three high frequencies in the better ear was significantly associated with CANTAB Delayed Matching to Sample (β = −0.16, p = 0.008), and Spatial Working Memory (β = 0.17, p = 0.003).Conclusion: The results revealed a significant relationship between age-related hearing loss and cognitive impairment in Mandarin-speaking older adults. These research outcomes have clinical implications specifically for hearing health care professionals in China and other populations that speak a tonal language, especially when providing hearing rehabilitation.

scholarly journals Evaluation of the Consonant Vowel Consonant (CVC) Test as an Assessment and Screening Instrument for Mild Cognitive Impairment

2015 ◽  
Vol 7 (4) ◽  
pp. 119 ◽  
Author(s):  
Esther Vierck ◽  
Richard J. Porter ◽  
Janet K. Spittlehouse ◽  
Peter R. Joyce
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Psychometric Properties ◽  
Word Learning ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Learning Task ◽  
Screening Instrument ◽  
Learning Tasks ◽  
Ceiling Effects

<p>Objective: Traditional word learning tasks have been criticised for being affected by ceiling effects. The Consonant Vowel Consonant (CVC) test is a non-word verbal learning task designed to be more difficult and therefore have a lower risk of ceiling effects.</p><p>Method: The current study examines the psychometric properties of the CVC in 404 middle-aged persons and evaluates it as a screening instrument for mild cognitive impairment by comparing it to the Montreal Cognitive Assessment (MoCA). Differences between currently depressed and non-depressed participants were also examined.</p><p>Results: CVC characteristics are similar to traditional verbal memory tasks but with reduced likelihood of a ceiling effect. Using the standard cut-off on the MoCA as an indication of mild cognitive impairment, the CVC performed only moderately well in predicting this. Depressed participants scored significantly lower on the CVC compared with non-depressed individuals.</p><p>Conclusions: The CVC may be similar in psychometric properties to the traditional word learning tests but with a higher ceiling. Scores are lower in depression.</p>

Is the WMS-IV Verbal Paired Associates as Effective as Other Memory Tasks in Discriminating Amnestic Mild Cognitive Impairment from Normal Aging?

2013 ◽  
Vol 27 (6) ◽  
pp. 908-923 ◽  
Author(s):  
Kerryn E. Pike ◽  
Glynda J. Kinsella ◽  
Ben Ong ◽  
Elizabeth Mullaly ◽  
Elizabeth Rand ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Normal Aging ◽  
Amnestic Mild Cognitive Impairment ◽  
Paired Associates

The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801

2010 ◽  
Vol 639 (1-3) ◽  
pp. 91-98 ◽  
Author(s):  
Karel Vales ◽  
Jan Svoboda ◽  
Kristina Benkovicova ◽  
Vera Bubenikova-Valesova ◽  
Ales Stuchlik
Keyword(s):  
Cognitive Impairment ◽  
Mk 801 ◽  
Receptor Agonists ◽  
Mglu5 Receptor ◽  
The Difference
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