Gut microbiota is involved in the antidepressant effects of adipose-derived mesenchymal stem cells in chronic social defeat stress mouse model

2022 ◽  
Author(s):  
Riyue Jiang ◽  
Yuanyuan Wang ◽  
Junbi Liu ◽  
Zifeng Wu ◽  
Di Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Antidepressant Effects ◽  
Chronic Social Defeat Stress

scholarly journals (R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress

2019 ◽  
Vol 22 (10) ◽  
pp. 675-679 ◽  
Author(s):  
Jiancheng Zhang ◽  
Youge Qu ◽  
Lijia Chang ◽  
Yaoyu Pu ◽  
Kenji Hashimoto
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Single Injection ◽  
Social Defeat ◽  
Spine Density ◽  
Social Defeat Stress ◽  
Dendritic Spine Density ◽  
Antidepressant Effects ◽  
Chronic Social Defeat Stress ◽  
Medial Pfc

Abstract Background A recent study demonstrated that spine formation rates by ketamine in the prefrontal cortex (PFC) were not altered at 3–6 h following a single injection, but were markedly altered at 12–24 h. Here, we investigated the acute (3 h post-treatment) effects of (R)-ketamine in the decreased spine density in the medial PFC (mPFC) and hippocampus in susceptible mice after chronic social defeat stress (CSDS). Methods (R)-ketamine (10 mg/kg) or saline was administered intraperitoneally to CSDS-susceptible mice. Dendritic spine density in the mPFC and hippocampus was measured 3 h after a single injection. Results (R)-ketamine significantly ameliorated the decreased spine density in the prelimbic area of mPFC, Cornu Ammonis3, and dentate gyrus of the hippocampus of CSDS-susceptible mice Conclusions This study suggests that (R)-ketamine rapidly ameliorates the decreased spine density in the mPFC and hippocampus of CSDS-susceptible mice, resulting in its rapid-acting antidepressant effects.

scholarly journals Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chun Yang ◽  
Yuko Fujita ◽  
Qian Ren ◽  
Min Ma ◽  
Chao Dong ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress

Antidepressant‐like effects of 20( S )‐protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms

2019 ◽  
Vol 33 (10) ◽  
pp. 2726-2736 ◽  
Author(s):  
Ning Jiang ◽  
Jing‐wei Lv ◽  
Hai‐xia Wang ◽  
Qiong Wang ◽  
Cong Lu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress

The Non‐Peptide Vasopressin V1b Receptor Antagonist, SSR149415, Ameliorates Spermatogenesis Function in a Mouse Model of Chronic Social Defeat Stress

2017 ◽  
Vol 118 (11) ◽  
pp. 3891-3898 ◽  
Author(s):  
Bin Wang ◽  
Jian Zhou ◽  
Yan‐Yan Zhuang ◽  
Liang‐Liang Wang ◽  
Jin‐Xian Pu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Receptor Antagonist ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Chronic Social Defeat Stress ◽  
V1b Receptor
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