Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

2018 ◽  
Vol 235 (11) ◽  
pp. 3177-3185 ◽  
Author(s):  
Kai Zhang ◽  
Hidetoh Toki ◽  
Yuko Fujita ◽  
Min Ma ◽  
Lijia Chang ◽  
...  
Keyword(s):  
Isotope Effects ◽  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Antidepressant Effects ◽  
Chronic Social Defeat Stress ◽  
Deuterium Isotope Effects

scholarly journals Antidepressant Effects of (+)-MK-801 and (-)-MK-801 in the Social Defeat Stress Model

2016 ◽  
Vol 19 (12) ◽  
pp. pyw080 ◽  
Author(s):  
Bangkun Yang ◽  
Qian Ren ◽  
Min Ma ◽  
Qian-Xue Chen ◽  
Kenji Hashimoto
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Mk 801 ◽  
Antidepressant Effects ◽  
The Social

scholarly journals Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

2016 ◽  
Vol 233 (19-20) ◽  
pp. 3647-3657 ◽  
Author(s):  
Bangkun Yang ◽  
Ji-chun Zhang ◽  
Mei Han ◽  
Wei Yao ◽  
Chun Yang ◽  
...  
Keyword(s):  
Social Defeat ◽  
Stress Model ◽  
Social Defeat Stress ◽  
Antidepressant Effects ◽  
The Social

scholarly journals (R)-Ketamine Rapidly Ameliorates the Decreased Spine Density in the Medial Prefrontal Cortex and Hippocampus of Susceptible Mice After Chronic Social Defeat Stress

2019 ◽  
Vol 22 (10) ◽  
pp. 675-679 ◽  
Author(s):  
Jiancheng Zhang ◽  
Youge Qu ◽  
Lijia Chang ◽  
Yaoyu Pu ◽  
Kenji Hashimoto
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Single Injection ◽  
Social Defeat ◽  
Spine Density ◽  
Social Defeat Stress ◽  
Dendritic Spine Density ◽  
Antidepressant Effects ◽  
Chronic Social Defeat Stress ◽  
Medial Pfc

Abstract Background A recent study demonstrated that spine formation rates by ketamine in the prefrontal cortex (PFC) were not altered at 3–6 h following a single injection, but were markedly altered at 12–24 h. Here, we investigated the acute (3 h post-treatment) effects of (R)-ketamine in the decreased spine density in the medial PFC (mPFC) and hippocampus in susceptible mice after chronic social defeat stress (CSDS). Methods (R)-ketamine (10 mg/kg) or saline was administered intraperitoneally to CSDS-susceptible mice. Dendritic spine density in the mPFC and hippocampus was measured 3 h after a single injection. Results (R)-ketamine significantly ameliorated the decreased spine density in the prelimbic area of mPFC, Cornu Ammonis3, and dentate gyrus of the hippocampus of CSDS-susceptible mice Conclusions This study suggests that (R)-ketamine rapidly ameliorates the decreased spine density in the mPFC and hippocampus of CSDS-susceptible mice, resulting in its rapid-acting antidepressant effects.

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