Chronic caffeine exposure potentiates nicotine self-administration in rats

1999 ◽  
Vol 142 (4) ◽  
pp. 327-333 ◽  
Author(s):  
M. Shoaib ◽  
Long S. Swanner ◽  
Sevil Yasar ◽  
Steven R. Goldberg
Keyword(s):  
Self Administration ◽  
Chronic Caffeine ◽  
Caffeine Exposure

scholarly journals Differential Effects of Caffeine on Motor and Cognitive Outcomes of Penetrating Ballistic-Like Brain Injury

2019 ◽  
Vol 184 (Supplement_1) ◽  
pp. 291-300
Author(s):  
Sarah S Sanjakdar ◽  
William J Flerlage ◽  
Hyun S Kang ◽  
Douglas A Napier ◽  
Jaqueline R Dougherty ◽  
...  
Keyword(s):  
Brain Injury ◽  
Morris Water Maze ◽  
Water Maze ◽  
Right Hemisphere ◽  
Cognitive Outcome ◽  
Post Injury ◽  
Caffeine Consumption ◽  
Morris Water Maze Task ◽  
Chronic Caffeine ◽  
Caffeine Exposure

Abstract This study assessed the effect of caffeine on neurobehavioral recovery in the WRAIR penetrating ballistic-like brain injury (PBBI) model. Unilateral frontal PBBI was produced in the right hemisphere of anesthetized rats at moderate (7%-PBBI) or severe (10%-PBBI) injury levels. Animals were randomly assigned to pretreatment groups: acute caffeine (25 mg/kg CAF gavage, 1 h prior to PBBI), or chronic caffeine (0.25 g/L CAF drinking water, 30 days prior to PBBI). Motor function was evaluated on the rotarod at fixed-speed increments of 10, 15, and 20 RPM. Cognitive performance was evaluated on the Morris water maze. Acute caffeine showed no significant treatment effect on motor or cognitive outcome. Acute caffeine exposure prior to 10%-PBBI resulted in a significantly higher thigmotaxic response compared to vehicle-PBBI groups, which may indicate caffeine exacerbates post-injury anxiety/attention decrements. Results of the chronic caffeine study revealed a significant improvement in motor outcome at 7 and 10 days post-injury in the 7%-PBBI group. However, chronic caffeine exposure significantly increased the latency to locate the platform in the Morris water maze task at all injury levels. Results indicate that chronic caffeine consumption prior to a penetrating TBI may provide moderate beneficial effects to motor recovery, but may worsen the neurocognitive outcome.

scholarly journals Chronic caffeine exposure in adolescence promotes diurnal, biphasic mood-cycling and enhanced motivation for reward in adult mice

2019 ◽  
Vol 370 ◽  
pp. 111943
Author(s):  
David J. Hinton ◽  
Lindsey G. Andres-Beck ◽  
Kelle E. Nett ◽  
Alfredo Oliveros ◽  
Sun Choi ◽  
...  
Keyword(s):  
Adult Mice ◽  
Chronic Caffeine ◽  
Caffeine Exposure

Adolescence chronic caffeine exposure promotes movement and mood disorders in mice

2017 ◽  
Vol 381 ◽  
pp. 220
Author(s):  
D. Hinton ◽  
S. Choi ◽  
A. Oliveros ◽  
D.S. Choi
Keyword(s):  
Mood Disorders ◽  
Chronic Caffeine ◽  
Caffeine Exposure

scholarly journals Effects of chronic caffeine exposure on adenosinergic modulation of the discriminative-stimulus effects of nicotine, methamphetamine, and cocaine in rats

2008 ◽  
Vol 203 (2) ◽  
pp. 355-367 ◽  
Author(s):  
Zuzana Justinova ◽  
Sergi Ferré ◽  
Chanel Barnes ◽  
Carrie E. Wertheim ◽  
Lara A. Pappas ◽  
...  
Keyword(s):  
Discriminative Stimulus ◽  
Discriminative Stimulus Effects ◽  
Stimulus Effects ◽  
Chronic Caffeine ◽  
Caffeine Exposure

Caffeine Delays Light-entrained Activity and Potentiates Circadian Photic Phase-resetting in Mice

2018 ◽  
Vol 33 (5) ◽  
pp. 523-534 ◽  
Author(s):  
Christina L. Ruby ◽  
Natalie M. Verbanes ◽  
Kaitlyn N. Palmer ◽  
Catherine F. Zisk ◽  
David J. Bunion ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Receptor Antagonist ◽  
High Dose ◽  
Phase Resetting ◽  
Circadian Activity ◽  
Self Administration ◽  
A2a Receptor ◽  
Adenosine A1 ◽  
Caffeine Exposure

Caffeine is widely used to reduce sedation and increase alertness. However, long-term caffeine use may disrupt circadian (daily, 24-h) rhythms and thereby negatively affect health. Here, we examined the effect of caffeine on photic regulation of circadian activity rhythms in mice. We found that entrainment to a standard 12-h light, 12-h dark (LD) photocycle was delayed during oral self-administration of caffeine. Both acute, high-dose caffeine and chronic, oral caffeine exposure potentiated photic phase-delays in mice, suggesting a possible mechanism by which entrainment to LD was delayed. The effect of caffeine on photic phase-resetting was mimicked by administration of adenosine A1, but not A2A, receptor antagonist in mice. Our results support the hypothesis that caffeine interferes with the ability of the circadian clock to respond normally to light.

scholarly journals Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems

2019 ◽  
Vol 148 ◽  
pp. 257-271 ◽  
Author(s):  
M.R. Arnold ◽  
P.H. Williams ◽  
J.A. McArthur ◽  
A.R. Archuleta ◽  
C.E. O'Neill ◽  
...  
Keyword(s):  
Rat Brain ◽  
Chronic Caffeine ◽  
Caffeine Exposure
Sign in / Sign up

Export Citation Format

Share Document