Multisensory stimuli shift perceptual priors to facilitate rapid behavior

Multisensory stimuli speed behavioral responses, but the mechanisms subserving these effects remain disputed. Historically, the observation that multisensory reaction times (RTs) outpace models assuming independent sensory channels has been taken as evidence for multisensory integration (the “redundant target effect”; RTE). However, this interpretation has been challenged by alternative explanations based on stimulus sequence effects, RT variability, and/or negative correlations in unisensory processing. To clarify the mechanisms subserving the RTE, we collected RTs from 78 undergraduates in a multisensory simple RT task. Based on previous neurophysiological findings, we hypothesized that the RTE was unlikely to reflect these alternative mechanisms, and more likely reflected pre-potentiation of sensory responses through crossmodal phase-resetting. Contrary to accounts based on stimulus sequence effects, we found that preceding stimuli explained only 3–9% of the variance in apparent RTEs. Comparing three plausible evidence accumulator models, we found that multisensory RT distributions were best explained by increased sensory evidence at stimulus onset. Because crossmodal phase-resetting increases cortical excitability before sensory input arrives, these results are consistent with a mechanism based on pre-potentiation through phase-resetting. Mathematically, this model entails increasing the prior log-odds of stimulus presence, providing a potential link between neurophysiological, behavioral, and computational accounts of multisensory interactions.

Multisensory Stimuli Shift Perceptual Priors to Favor Rapid Detection

Multisensory stimuli speed behavioral responses, but the mechanisms subserving these effects remain disputed. Historically, the observation that multisensory reaction times (RTs) outpace models assuming independent sensory channels has been taken as evidence for multisensory integration (the “redundant target effect”; RTE). However, this interpretation has been challenged by alternative explanations based on stimulus sequence effects, RT variability, and/or negative correlations in unisensory processing. To clarify the mechanisms subserving the RTE, we collected RTs from 78 undergraduates in a multisensory simple RT task. Based on previous neurophysiological findings, we hypothesized that the RTE was unlikely to reflect these alternative mechanisms, and more likely reflected pre-potentiation of sensory responses through crossmodal phase-resetting. Contrary to accounts based on stimulus sequence effects, we found that preceding stimuli explained only 3-9% of the variance in apparent RTEs. Comparing three plausible evidence accumulator models, we found that multisensory RT distributions were best explained by increased sensory evidence at stimulus onset. Because crossmodal phase-resetting increases cortical excitability before sensory input arrives, these results are consistent with a mechanism based on pre-potentiation through phase-resetting. Mathematically, this model entails increasing the prior log-odds of stimulus presence, providing a potential link between neurophysiological, behavioral, and computational accounts of multisensory interactions.

The Circadian Phase Response Curve to Light: Conservation across Seasons and Anchorage to Sunset

Predictions about circadian light responses are largely based on photic phase-response curves (PRCs) generated from animals housed under seasonally agnostic equatorial photoperiods with alternating 12-hour segments of light and darkness. Most of the human population, however, lives at northerly latitudes where seasonal variations in the light-dark schedule are pronounced. Here, we address this disconnect by constructing the first high-resolution seasonal atlas for light-induced circadian phase-resetting. Testing the light responses of nearly 4,000 Drosophila at 120 timepoints across 5 seasonally relevant photoperiods, we determined that many aspects of the circadian PRC waveform are conserved with increasing daylength. Surprisingly though, irrespective of LD schedule, the start of the PRCs always remained anchored to the timing of subjective sunset, creating a differential overlap of the advance zone with the morning hours after subjective sunrise that was maximized under summer photoperiods and minimized under winter photoperiods. These data suggest that circadian photosensitivity is effectively extinguished by the early winter morning and out of optimal phase alignment with the wake schedules of many individuals. They raise the possibility that phototherapy protocols for conditions such as seasonal depression might be improved with programmed light exposure during the final hours of sleep.

The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders

Sensory processing is disrupted in several psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorder. In this review, we focus on the electrophysiological auditory steady-state response (ASSR) driven by high-frequency stimulus trains as an index for disease-associated sensory processing deficits. The ASSR amplitude is suppressed within the gamma band (≥30 Hz) among these patients, suggesting an imbalance between GABAergic and N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission. The reduced power and synchronization of the 40-Hz ASSR are robust in patients with schizophrenia. In recent years, similar ASSR deficits at gamma frequencies have also been reported in patients with bipolar disorder and autism spectrum disorder. We summarize ASSR abnormalities in each of these psychiatric disorders and suggest that the observed commonalities reflect shared pathophysiological mechanisms. We reviewed studies on phase resetting in which a salient sensory stimulus affects ASSR. Phase resetting induces the reduction of both the amplitude and phase of ASSR. Moreover, phase resetting is also affected by rare auditory stimulus patterns or superimposed stimuli of other modalities. Thus, sensory memory and multisensory integration can be investigated using phase resetting of ASSR. Here, we propose that ASSR amplitude, phase, and resetting responses are sensitive indices for investigating sensory processing dysfunction in psychiatric disorders.

Revealing the Physiological Origin of Event-Related Potentials using Electrocorticography in Humans

The scientific and clinical value of event-related potentials (ERPs) depends on understanding the contributions to them of three possible mechanisms: (1) additivity of time-locked voltage changes; (2) phase resetting of ongoing oscillations; (3) asymmetrical oscillatory activity. Their relative contributions are currently uncertain. This study uses analysis of human electrocorticographic activity to quantify the origins of movement-related potentials (MRPs) and auditory evoked potentials (AEPs). The results show that MRPs are generated primarily by endogenous additivity (88%). In contrast, P1 and N1 components of AEPs are generated almost entirely by exogenous phase reset (93%). Oscillatory asymmetry contributes very little. By clarifying ERP mechanisms, these results enable creation of ERP models; and they enhance the value of ERPs for understanding the genesis of normal and abnormal auditory or sensorimotor behaviors.