Ascorbic Acid Deficiency, Iron Overload and Alcohol Abuse Underlie the Severe Osteoporosis in Black African Patients with Hip Fractures — A Bone Histomorphometric Study

2004 ◽  
Vol 76 (2) ◽  
pp. 79-89 ◽  
Author(s):  
C. M. Schnitzler ◽  
E. Schnaid ◽  
A. P. MacPhail ◽  
J. M. Mesquita ◽  
H. J. Robson
Keyword(s):  
Ascorbic Acid ◽  
Alcohol Abuse ◽  
Iron Overload ◽  
Hip Fractures ◽  
Severe Osteoporosis ◽  
Black African ◽  
Ascorbic Acid Deficiency ◽  
Histomorphometric Study ◽  
Acid Deficiency ◽  
African Patients

scholarly journals The effect of siderosis and ascorbic acid depletion on bone metabolism, with special reference to osteoporosis in the Bantu

1971 ◽  
Vol 25 (3) ◽  
pp. 367-376 ◽  
Author(s):  
A. A. Wapnick ◽  
S. R. Lynch ◽  
H. C. Seftel ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Bone Resorption ◽  
Bone Formation ◽  
Iron Overload ◽  
Bone Mineral ◽  
Guinea Pigs ◽  
Iron Concentration ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency ◽  
Liver Storage

1. There is an association between iron overload, ascorbic acid deficiency and osteoporosis in middle-aged South African Bantu males. The iron overload contributes to the ascorbic acid deficiency by accelerating its oxidative catabolism. The object of the present investigation was to explore the possibility that the osteoporosis results from chronic ascorbic acid deficiency.2. On quantitative microradiography, percentage bone-formation surface was normal but percentage bone-resorption surface was significantly increased in ten osteoporotic subjects compared with seven control subjects.3. There was a significant inverse correlation between bone mineral density and liver storage iron concentration in thirty-five Bantu subjects. In thirteen individuals aged 39 years or less, liver storage iron concentration was significantly correlated with percentage bone-resorption surface.4. Guinea-pigs deprived of ascorbic acid for 21 d exhibited both significantly diminished percentage bone-formation surface and increased percentage bone-resorption surface.5. Guinea-pigs overloaded with iron by injections of iron dextran developed significantly reduced hepatic ascorbic acid concentrations and bone mineral densities; percentage bone-formation surface was significantly diminished and percentage bone-resorption surface significantly increased. Ascorbic acid injection largely prevented the bone changes.

EXPERIMENTAL ATHEROSCLEROSIS WITH ASCORBIC ACID DEFICIENCY

1971 ◽  
Vol 35 (12) ◽  
pp. 1559-1565 ◽  
Author(s):  
TAKAO FUJITANI ◽  
KOTA OKADO ◽  
KATSUJI SENDA ◽  
MUNEAKI SUGIMURA ◽  
MOTOAKI KISHIKAWA
Keyword(s):  
Ascorbic Acid ◽  
Experimental Atherosclerosis ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

Ascorbic Acid Deficiency —

1981 ◽  
Vol 5 (6) ◽  
pp. 531-532 ◽  
Author(s):  
R.E. Hodges ◽  
J.E. Canham ◽  
J.L. Smith
Keyword(s):  
Ascorbic Acid ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency

Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ods rats

1997 ◽  
Vol 42 (10-11) ◽  
pp. 695-704 ◽  
Author(s):  
Motonari Ogawara ◽  
Kazuhiro Aoki ◽  
Takashi Okiji ◽  
Hideaki Suda
Keyword(s):  
Ascorbic Acid ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency
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