The Effect of Recombinant PTH(1–34) and PTH(1–84) on Serum Ionized Calcium, 1,25-Dihydroxyvitamin D, and Urinary Calcium Excretion: A Pilot Study

2009 ◽  
Vol 85 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Sara Piemonte ◽  
Elisabetta Romagnoli ◽  
Cristiana Cipriani ◽  
Valeria Fassino ◽  
Romano Del Fiacco ◽  
...  
2007 ◽  
Vol 103 (3-5) ◽  
pp. 803-806 ◽  
Author(s):  
Ali Halhali ◽  
Lorenza Díaz ◽  
Euclides Avila ◽  
Ana Carolina Ariza ◽  
Michèle Garabédian ◽  
...  

1993 ◽  
Vol 84 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Sandro Giannini ◽  
Martino Nobile ◽  
Rocco Castrignano ◽  
Tecla Pati ◽  
Andrea Tasca ◽  
...  

1. Vitamin D seems to play an essential role in the pathogenesis of idiopathic hypercalciuria at least in part via intestinal hyperabsorption of calcium. Hyper-absorption of calcium, in turn, might enhance the intestinal uptake of free oxalate, thus leading to hyperoxaluria. To verify this hypothesis we studied 75 calcium-stone-formers subdivided as follows: group 1 (15 patients) with isolated hyperoxaluria; group 2 (25 patients) with hyperoxaluria and hypercalciuria; group 3 (22 patients) with isolated hypercalciuria; group 4 (12 patients) with no metabolic abnormalities. 2. As expected, urinary calcium excretion differed in the various groups (P < 0.001), being highest in groups 2 and 3; urinary oxalate excretion, by definition highest in groups 1 and 2, was even more pronounced in group 2 than in group 1 (P < 0.05). Although in the normal range, the serum 1,25-dihydroxyvitamin D concentration was higher (P < 0.001) in the two hypercalciuric groups (2 and 3), showing peak levels in group 2. 3. When the data from the 75 stone-formers were pooled, there was a positive correlation between the serum concentration of 1,25-dihydroxyvitamin D and urinary calcium excretion (P < 0.001) and urinary oxalate excretion (P < 0.003), the latter relationship also being present when only the two hypercalciuric groups (groups 2 and 3) were considered together (P < 0.05). 4. Our data seem to confirm a relevant role for the vitamin D system in the pathogenesis of calcium nephrolithiasis due to increased intestinal calcium absorption, but also because this in turn induces a greater intestinal absorption of oxalate, thus leading to the occurrence or exacerbation of hyperoxaluria.


1998 ◽  
Vol 18 (3) ◽  
pp. 475-487 ◽  
Author(s):  
Susan J Whiting ◽  
Timothy J Green ◽  
Evelyn P MacKenzie ◽  
Shawna J Weeks

Sign in / Sign up

Export Citation Format

Share Document