External evaluation of published population pharmacokinetic models of polymyxin B

2021 ◽  
Author(s):  
Ya-qian Li ◽  
Kai-feng Chen ◽  
Jun-jie Ding ◽  
Hong-yi Tan ◽  
Nan Yang ◽  
...  
Keyword(s):  
Polymyxin B ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation

scholarly journals External Evaluation of Population Pharmacokinetic Models and Bayes-Based Dosing of Infliximab

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1191
Author(s):  
Celine Konecki ◽  
Catherine Feliu ◽  
Yoann Cazaubon ◽  
Delphine Giusti ◽  
Marcelle Tonye-Libyh ◽  
...  
Keyword(s):  
Goodness Of Fit ◽  
Inflammatory Diseases ◽  
Plasma Concentrations ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation ◽  
Immunomodulatory Treatment ◽  
Weighted Residuals ◽  
Prediction Distribution ◽  
Target Plasma

Despite the well-demonstrated efficacy of infliximab in inflammatory diseases, treatment failure remains frequent. Dose adjustment using Bayesian methods has shown in silico its interest in achieving target plasma concentrations. However, most of the published models have not been fully validated in accordance with the recommendations. This study aimed to submit these models to an external evaluation and verify their predictive capabilities. Eight models were selected for external evaluation, carried out on an independent database (409 concentrations from 157 patients). Each model was evaluated based on the following parameters: goodness-of-fit (comparison of predictions to observations), residual error model (population weighted residuals (PWRES), individual weighted residuals (IWRES), and normalized prediction distribution errors (NPDE)), and predictive performances (prediction-corrected visual predictive checks (pcVPC) and Bayesian simulations). The performances observed during this external evaluation varied greatly from one model to another. The eight evaluated models showed a significant bias in population predictions (from −7.19 to 7.38 mg/L). Individual predictions showed acceptable bias and precision for six of the eight models (mean error of −0.74 to −0.29 mg/L and mean percent error of −16.6 to −0.4%). Analysis of NPDE and pcVPC confirmed these results and revealed a problem with the inclusion of several covariates (weight, concomitant immunomodulatory treatment, presence of anti-drug antibodies). This external evaluation showed satisfactory results for some models, notably models A and B, and highlighted several prospects for improving the pharmacokinetic models of infliximab for clinical-biological application.

scholarly journals External evaluation of population pharmacokinetic models for ciclosporin in adult renal transplant recipients

2017 ◽  
Vol 84 (1) ◽  
pp. 153-171 ◽  
Author(s):  
Jun-Jun Mao ◽  
Zheng Jiao ◽  
Hwi-Yeol Yun ◽  
Chen-Yan Zhao ◽  
Han-Chao Chen ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Population Pharmacokinetic ◽  
Renal Transplant Recipients ◽  
Pharmacokinetic Models ◽  
Transplant Recipients ◽  
External Evaluation

External evaluation of population pharmacokinetic models for continuous administration of meropenem in critically ill adult patients

2020 ◽  
Vol 76 (9) ◽  
pp. 1281-1289
Author(s):  
YL. Wang ◽  
R. Guilhaumou ◽  
O. Blin ◽  
L. Velly ◽  
Amélie Marsot
Keyword(s):  
Critically Ill ◽  
Adult Patients ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation ◽  
Continuous Administration

scholarly journals External Evaluation of Population Pharmacokinetic Models of Imatinib in Adults Diagnosed with Chronic Myeloid Leukaemia

2021 ◽  
Author(s):  
Álvaro Corral Alaejos ◽  
Aránzazu Zarzuelo Castañeda ◽  
Silvia Jiménez Cabrera ◽  
Fermín Sánchez‐Guijo ◽  
María José Otero ◽  
...  
Keyword(s):  
Chronic Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation

Simulations of Valproate Doses Based on an External Evaluation of Pediatric Population Pharmacokinetic Models

2018 ◽  
Vol 59 (3) ◽  
pp. 406-417 ◽  
Author(s):  
Manon Tauzin ◽  
Jean-Marc Tréluyer ◽  
Rima Nabbout ◽  
Thierry Billette de Villemeur ◽  
Isabelle Desguerre ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation

scholarly journals Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients

2021 ◽  
Author(s):  
Patrick O. Hanafin ◽  
Roger L. Nation ◽  
Marc H. Scheetz ◽  
Alexandre P. Zavascki ◽  
Ana M. Sandri ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Predictive Performance ◽  
Polymyxin B ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models

External evaluation of the predictive performance of seven population pharmacokinetic models for phenobarbital in neonates

2021 ◽  
Author(s):  
Sunae Ryu ◽  
Woo Jin Jung ◽  
Zheng Jiao ◽  
Jung‐Woo Chae ◽  
Hwi‐yeol Yun
Keyword(s):  
Predictive Performance ◽  
Population Pharmacokinetic ◽  
Pharmacokinetic Models ◽  
External Evaluation

scholarly journals External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings

2013 ◽  
Vol 75 (4) ◽  
pp. 1068-1080 ◽  
Author(s):  
Wei Zhao ◽  
Florentia Kaguelidou ◽  
Valérie Biran ◽  
Daolun Zhang ◽  
Karel Allegaert ◽  
...  
Keyword(s):  
Population Pharmacokinetic ◽  
Clinical Settings ◽  
Pharmacokinetic Models ◽  
External Evaluation
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