Symptomatic Schmorl’s nodes: role of percutaneous vertebroplasty. Open study on 52 patients

2019 ◽  
Vol 61 (4) ◽  
pp. 405-410 ◽  
Author(s):  
Nicolas Amoretti ◽  
Sylvain Guinebert ◽  
Adrian Kastler ◽  
Federico Torre ◽  
Olivier Andreani ◽  
...  
Keyword(s):  
Open Study ◽  
Percutaneous Vertebroplasty ◽  
Schmorl’S Nodes

Prospective, noncomparative open study from Kuwait of the role of intravenous immunoglobulin in the treatment of toxic epidermal necrolysis

2004 ◽  
Vol 43 (11) ◽  
pp. 847-851 ◽  
Author(s):  
N Al-Mutairi ◽  
Joshi Arun ◽  
Nour-Eldin Osama ◽  
Zaki Amr ◽  
Al-Sheltawy Mazen ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Intravenous Immunoglobulin ◽  
Open Study

scholarly journals Clinical Evaluation of Percutaneous Vertebroplasty in a Patient with Paraplegia and Immobilization Syndrome: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Salvatore Masala ◽  
Eros Calabria ◽  
Marco Nezzo ◽  
Dominique De Vivo ◽  
Luca Neroni ◽  
...  
Keyword(s):  
Potential Role ◽  
Percutaneous Vertebroplasty ◽  
Life Quality ◽  
Osteoporotic Fractures ◽  
Well Being ◽  
Vertebral Compression Fractures ◽  
Decubitus Ulcers ◽  
Compression Fractures ◽  
Vertebral Stabilization

We will discuss a potential role of percutaneous vertebroplasty (PVP) in the management of a patient with immobilization syndrome due to paraplegia and vertebral osteoporotic fractures. While PVP is commonly used for the treatment of osteoporotic thoracolumbar vertebral compression fractures, its role in vertebral stabilization in patient with immobilization syndrome has not been reported in the literature. A 73-year-old woman affected by immobilization syndrome due to paraplegia and vertebral osteoporotic fractures was treated with PVP of vertebrae D12, L1, and L4. After PVP, the patient did not need any antalgic therapy, and there was a significant improvement regarding mobilization, performance of physiological functions, daily management of personal care, and treatment of decubitus ulcers, increasing life quality and psychological well-being.

scholarly journals ROLE OF DENDRIMERS IN ADVANCED DRUG DELIVERY AND BIOMEDICAL APPLICATIONS: A REVIEW

2018 ◽  
Vol 40 (3) ◽  
pp. 178-183 ◽  
Author(s):  
A Akbarzadeh ◽  
R Khalilov ◽  
E Mostafavi ◽  
N Annabi ◽  
T Kafshdooz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Retention Time ◽  
Structural Design ◽  
Open Study ◽  
Biomedical Applications ◽  
Delivery Vehicle ◽  
Chemical Substances ◽  
Biologically Relevant ◽  
Polymer Size

Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration. This article reviews role of dendrimers in advanced drug delivery and biomedical applications.

Differential effects of transdermal nicotine on microstructured analyses of tics in Tourette's syndrome: an open study

1997 ◽  
Vol 27 (2) ◽  
pp. 483-487 ◽  
Author(s):  
SERDAR M. DURSUN ◽  
MICHAEL A. REVELEY
Keyword(s):  
Open Study ◽  
Nicotine Patch ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Transdermal Nicotine ◽  
Tic Severity ◽  
Structured Analysis ◽  
Transdermal Nicotine Patch ◽  
Haloperidol Treatment

Background. The treatment of Tourette's syndrome (TS) is often unsatisfactory. However, there is some evidence that transdermal nicotine patch (TNP) application may improve tics of non-smoking TS patients who are refractory to haloperidol treatment.Methods. In this open study we applied two 10 mg TNP for 2 consecutive days to four TS patients whose symptoms were not controlled by haloperidol and to a never-medicated TS patient, all of whom are non-smokers. The Yale Global Tic Severity Scale (YGTSS) and a quantified video-taped micro-structured analysis of tics (head-shake tics, eye-blinks, vocal tics, facial grimace and other body tics) were both carried out to assess the change after the application of TNP.Results. TNP application significantly reduced the YGTSS by an average of 50%, with no reported side-effects, for up to 4 weeks but not 16 weeks, as compared with TNP-free period. Consistent with these results, the total counts of tics also showed a significant decrease for up to 4 weeks after the TNP application.Conclusion. TNP application differentially affected individually quantified tics, which may suggest a differential role of nicotinic receptors in the generation of different tics.

scholarly journals Percutaneous Vertebroplasty for Symptomatic Schmorl’s Nodes: 11 Cases with Long-term Follow-up and a Literature Review

2017 ◽  
Vol 2 (20;2) ◽  
pp. 69-75
Author(s):  
Gao-Jun Teng
Keyword(s):  
Physical Therapy ◽  
Percutaneous Vertebroplasty ◽  
Case Series ◽  
Small Sample ◽  
Vertebral Compression Fractures ◽  
Safe Procedure ◽  
Long Term Follow Up ◽  
Schmorl’S Nodes

Background: Percutaneous vertebroplasty (PVP) is commonly used to treat symptomatic vertebral compression fractures. However, its long-term effectiveness and safety for use in the treatment of symptomatic Schmorl’s nodes (SNs) refractory to conservative treatment is uncertain. Objectives: To present a case series with PVP for symptomatic SNs not responding to conservative therapy and assess the effectiveness and safety for such treatment with long-term follow-up. To present a review of the literature regarding SNs and treatment options. Study Design: Single center retrospective observational study. Setting: This study consists of patients from a large academic center in China. Methods: Between January 2008 and December 2013, 11 patients suffering from symptomatic SNs that were refractory to medical or physical therapy, underwent PVP procedures in our department. All patients had a definitive diagnosis of SNs by magnetic resonance imaging (MRI) and computed tomography (CT). The visual analog scale (VAS) was assessed preoperatively at 4 hours, at one month, and every 6 months postoperatively during the long-term (mean: 58.0 months) follow-up period. Results: Each of the 11 patients reported an immediate and distinct relief of their back pain. No one reported a worsening of symptoms. The VAS decreased from an average preprocedural score of 7.9 to a postprocedural score of 2.1 at 4 hours. The VAS averaged 1.8 during the mean followup period of 58.0 (range 24.1 to 98.9) months. There were no postoperative complications during the follow-up period. At the end of the follow-up period, all 11 patients were unrestricted in their activities. Limitations: This study is a retrospective study with a small sample size. Conclusions: PVP is an effective and safe procedure for the treatment of symptomatic SNs, which are refractory to medical or physical therapy. Key words: Percutaneous vertebroplasty, symptomatic Schmorl’s nodes, vertebral endplate fracture, endplate osteonecrosis, Modic changes

Role of infliximab in the treatment of refractory severe ulcerative colitis: An open study

2001 ◽  
Vol 33 ◽  
pp. A30
Author(s):  
R. Sostegni ◽  
M. Daperno ◽  
C. Laudi ◽  
E. Ercole ◽  
C. Rigazio ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Open Study ◽  
Severe Ulcerative Colitis

Possible key role of immune system in Schmorl’s nodes

2010 ◽  
Vol 74 (3) ◽  
pp. 552-554 ◽  
Author(s):  
Ning Zhang ◽  
Fang-Cai Li ◽  
Yi-Jiang Huang ◽  
Chong Teng ◽  
Wei-Shan Chen
Keyword(s):  
Immune System ◽  
Schmorl’S Nodes

scholarly journals Traumatic Burst Fracture with Spinal Channel Involvement Augmentation with Bioactive Strontium-Hydroxyapatite Cement

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
S. Masala ◽  
E. Calabria ◽  
G. Nano ◽  
R. Iundusi ◽  
L. Greco ◽  
...  
Keyword(s):  
Potential Role ◽  
Percutaneous Vertebroplasty ◽  
Burst Fracture ◽  
Posterior Wall ◽  
Cement Leakage ◽  
Strontium Hydroxyapatite ◽  
Hydroxyapatite Cement ◽  
Pain Improvement ◽  
Very High

In November 2011 a 75-year-old man was admitted to our emergency department with a low back pain caused by a traumatic L1 vertebral collapse with backward projection of posterior wall superior third. The indication for neurosurgical instrumentation was placed, although he refused the treatment. Hence he was treated conservatively without a significant improvement up to January 2012 when, still refusing surgery, he accepted to undergo percutaneous vertebroplasty with a novel bioactive injectable strontium-hydroxyapatite cement. Vertebroplasty was performed without complications. A CT scan, performed the day after the procedure, ruled out extravertebral cement leakage. Pain improvement was significant (preprocedure VAS 10, one-week VAS 4) with a gradual decrease up to three months when it stabilized at 2. CT examination after 1 year showed a good cement osseointegration with osteophytic spurs bridging the superior endplate of the level involved to the inferior one of the level above. The new bone ingrowing property of the strontium-hydroxyapatite containing cement permits to extend the treatment indication also to unstable collapses in which the risk of pseudoarthrosis is very high. In this reported case we evaluated the potential role of percutaneous vertebroplasty in traumatic burst fracture with spinal channel involvement.

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