Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients

2007 ◽  
Vol 59 (3) ◽  
pp. 177-186 ◽  
Author(s):  
Justin P. Rubio ◽  
Melanie Bahlo ◽  
Jim Stankovich ◽  
Rachel K. Burfoot ◽  
Laura J. Johnson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Class I ◽  
Hla Haplotypes ◽  
Class I Region

Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis

2004 ◽  
Vol 63 (3) ◽  
pp. 237-247 ◽  
Author(s):  
H.F. Harbo ◽  
B.A. Lie ◽  
S. Sawcer ◽  
E.G. Celius ◽  
K.-Z. Dai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Susceptibility ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I ◽  
Class I Region

Nucleotide Sequencing Analysis of the 146-Kilobase Segment around theIkBLandMICAGenes at the Centromeric End of the HLA Class I Region

Genomics ◽  
1998 ◽  
Vol 47 (3) ◽  
pp. 372-382 ◽  
Author(s):  
Takashi Shiina ◽  
Gen Tamiya ◽  
Akira Oka ◽  
Tetsushi Yamagata ◽  
Naomi Yamagata ◽  
...  
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Nucleotide Sequencing ◽  
Sequencing Analysis ◽  
Class I Region

A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region

1993 ◽  
Vol 38 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Corine Vernet ◽  
Marie-Th�r�se Ribouchon ◽  
Giovanna Chimini ◽  
Anne-Marie Jouanolle ◽  
Issa Sidib� ◽  
...  
Keyword(s):  
Gene Family ◽  
Mhc Class I ◽  
Class I ◽  
Coding Sequence ◽  
Multicopy Gene ◽  
Class I Region

Multiplex PCR of three dinucleotide markers in the HLA class I region: D6S2792, D6S273 and D6S2972

2008 ◽  
Vol 1 (1) ◽  
pp. 370-372 ◽  
Author(s):  
E.M. Schwartz-Jungl ◽  
E.M. Dauber ◽  
S. Wenda ◽  
G. Dorner ◽  
B. Glock ◽  
...  
Keyword(s):  
Multiplex Pcr ◽  
Hla Class I ◽  
Class I ◽  
Class I Region

Pinpointing a selective sweep to the chimpanzee MHC class I region by comparative genomics

2008 ◽  
Vol 17 (8) ◽  
pp. 2074-2088 ◽  
Author(s):  
NATASJA G. DE GROOT ◽  
CORRINE M. C. HEIJMANS ◽  
NANINE DE GROOT ◽  
NEL OTTING ◽  
ANNEMIEK J. M. DE VOS-ROUWELER ◽  
...  
Keyword(s):  
Comparative Genomics ◽  
Mhc Class I ◽  
Selective Sweep ◽  
Class I ◽  
Class I Region

Molecular analysis of the human MHC class I region in hereditary haemochromatosis

1990 ◽  
Vol 85 (5) ◽  
Author(s):  
DeirdreK. Lord ◽  
I. Dunham ◽  
R.Duncan Campbell ◽  
Adrian Bomford ◽  
Tom Strachan ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Molecular Analysis ◽  
Class I ◽  
Hereditary Haemochromatosis ◽  
Class I Region

scholarly journals Multiple sclerosis: disease modifying therapy and the human leukocyte antigen

2018 ◽  
Vol 76 (10) ◽  
pp. 697-704 ◽  
Author(s):  
Lineu Cesar Werneck ◽  
Paulo José Lorenzoni ◽  
Cláudia Suemi Kamoi Kay ◽  
Rosana Herminia Scola
Keyword(s):  
Multiple Sclerosis ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Class I ◽  
Interferon Β ◽  
Leukocyte Antigen ◽  
Specific Subset ◽  
Hla Type ◽  
Disease Modifying

ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginning and end of each type of DMT including the disease duration, Expanded Disability Status Scale and Multiple Sclerosis Severity Score (MSSS). Genotyping of HLA-DRB1, HLA-DPB1, HLA-DQB1, HLA-A, HLA-B and HLA-C alleles were identified using high-resolution techniques. Statistical correlation between the HLA type and response to DMTs was done using the initial and final MSSS. Results: Statistical relationships (p < 0.05) were found for only 15 of 245 alleles tested. There was a reduction in the MSSS for patients treated with corticosteroids (DRB1*15:01, DPB1*04:01, DQB1*02:01 and DQB1*03:01), azathioprine (DRB1*03:01, DPB1*04:01, DQB1*03:02, DQB1*06:02, HLA-C*07:02), interferon β-1a 22 mcg (DRB1*11:04, DQB1*03:01 and DQB1*03:02), interferon β-1a 30 mcg (DPB1*02:01, HLA-C*05:01) and interferon β-1b (DQB1*02:01). Conclusion: These findings suggest a few relationships between the HLA and response to DMTs in the disability for some types of HLA class I and II alleles in a specific subset of MS patients.

scholarly journals Characterization of microsatellite loci in the SLA class I region

Genomics ◽  
2011 ◽  
Vol 97 (4) ◽  
pp. 223-234 ◽  
Author(s):  
Hoyoung Chung ◽  
Matthew Charles McClure
Keyword(s):  
Microsatellite Loci ◽  
Class I ◽  
Class I Region
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