In vitro antioxidant activities of Rhodobacter sphaeroides and protective effect on Caco-2 cell line model

2018 ◽  
Vol 103 (2) ◽  
pp. 917-927 ◽  
Author(s):  
Jun An ◽  
Cui Yang ◽  
Zuming Li ◽  
Patricia W. Finn ◽  
David L. Perkins ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cell Line ◽  
Rhodobacter Sphaeroides ◽  
Antioxidant Activities ◽  
Line Model ◽  
Cell Line Model

BIOAVAILABILITY OF BERYLLIUM OXIDE PARTICLES: AN IN VITRO STUDY IN THE MURINE J774A.1 MACROPHAGE CELL LINE MODEL

2005 ◽  
Vol 31 (3) ◽  
pp. 341-360 ◽  
Author(s):  
Gregory A. Day ◽  
Mark D. Hoover ◽  
Aleksandr B. Stefaniak ◽  
Robert M. Dickerson ◽  
Eric J. Peterson ◽  
...  
Keyword(s):  
Cell Line ◽  
In Vitro Study ◽  
Beryllium Oxide ◽  
Vitro Study ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Line Model ◽  
Cell Line Model ◽  
Oxide Particles

Natural Fe isotope fractionation in an intestinal Caco-2 cell line model

2017 ◽  
Vol 32 (9) ◽  
pp. 1713-1720 ◽  
Author(s):  
María R. Flórez ◽  
Yulia Anoshkina ◽  
Marta Costas-Rodríguez ◽  
Charlotte Grootaert ◽  
John Van Camp ◽  
...  
Keyword(s):  
Cell Line ◽  
Isotope Fractionation ◽  
Line Model ◽  
Cell Line Model

Caco-2 cells were used in anin vitromodel for studying the Fe isotope fractionation accompanying intestinal Fe fluxes.

scholarly journals Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a ClinicalStaphylococcus aureusStrain with a Small-Colony-Variant Phenotype in anIn VitroModel of THP-1 Macrophages and anIn VivoMouse Peritonitis Model

2011 ◽  
Vol 55 (4) ◽  
pp. 1443-1452 ◽  
Author(s):  
Anne Sandberg ◽  
Sandrine Lemaire ◽  
Françoise Van Bambeke ◽  
Paul M. Tulkens ◽  
Diarmaid Hughes ◽  
...  
Keyword(s):  
Cell Line ◽  
Recurrent Infection ◽  
Line Model ◽  
Small Colony Variant ◽  
Cell Line Model ◽  
Optimal Dosing ◽  
Small Colony ◽  
Peritonitis Model

ABSTRACTThe small-colony-variant (SCV) phenotype ofStaphylococcus aureushas been associated with difficult-to-treat infections, reduced antimicrobial susceptibility, and intracellular persistence. This study represents a detailed intra- and extracellular investigation of a clinical wild-type (WT)S. aureusstrain and its counterpart with an SCV phenotype bothin vitroandin vivo, using the THP-1 cell line model and the mouse peritonitis model, respectively. Bacteria of both phenotypes infected the mouse peritoneum intra- and extracellularly. The SCV phenotype was less virulent and showed distinct bacterial clearance, a reduced multiplication capacity, and a reduced internalization ability. However, some of the SCV-infected mice were still culture positive up to 96 h postinfection, and bacteria of this phenotype could spread to the mouse kidney and furthermore revert to the more virulent WT phenotype in both the mouse peritoneum and kidney. The SCV phenotype is therefore, despite reduced virulence, an important player inS. aureuspathogenesis. In the THP-1 cell line model, both dicloxacillin (DCX) and linezolid (LZD) reduced the intracellular inocula of bacteria of both phenotypes by approximately 1 to 1.5 log10in vitro, while DCX was considerably more effective against extracellular bacteria. In the mouse peritonitis model, DCX and LZD were also able to control both intra- and extracellular infections caused by either phenotype. Treatment with a single dose of DCX and LZD was, however, insufficient to clear the SCVs in the kidneys, and the risk of recurrent infection remained. This stresses the importance of an optimal dosing of the antibiotic when SCVs are present.

Peritoneal sarcomatosis: site of origin for the establishment of an in vitro and in vivo cell line model to study therapeutic resistance in dedifferentiated liposarcoma

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 2341-2351 ◽  
Author(s):  
Sabrina Mersch ◽  
Jasmin C. Riemer ◽  
Philipp M. Schlünder ◽  
Markus P. Ghadimi ◽  
Hany Ashmawy ◽  
...  
Keyword(s):  
Cell Line ◽  
Dedifferentiated Liposarcoma ◽  
Therapeutic Resistance ◽  
Line Model ◽  
Cell Line Model
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