Correlation between water content and magnetization transfer ratio of the water component in bone marrow using gradient-echo imagings: normal case study

1998 ◽  
Vol 27 (9) ◽  
pp. 484-487 ◽  
Author(s):  
Yasuo Amano ◽  
Tatsuo Kumazaki
Keyword(s):  
Bone Marrow ◽  
Water Content ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Gradient Echo ◽  
Normal Case ◽  
Transfer Ratio

A fast B1-mapping method for the correction and normalization of magnetization transfer ratio maps at 3 T

NeuroImage ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 3015-3026 ◽  
Author(s):  
Steffen Volz ◽  
Ulrike Nöth ◽  
Anna Rotarska-Jagiela ◽  
Ralf Deichmann
Keyword(s):  
Magnetization Transfer ◽  
Mapping Method ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
B1 Mapping

Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study

2006 ◽  
Vol 12 (5) ◽  
pp. 662-665 ◽  
Author(s):  
A Charil ◽  
D Caputo ◽  
R Cavarretta ◽  
M P Sormani ◽  
P Ferrante ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Relapse Rate ◽  
Magnetization Transfer ◽  
Small Sample ◽  
Cervical Cord ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Disease Evolution ◽  
Transfer Ratio ◽  
Relapsing Remitting

Background Magnetization transfer ratio (MTR) permits the quantitative estimation of cervical cord tissue damage in patients with multiple sclerosis (MS). Objective To determine whether a single time-point MTR scan of the cervical cord is associated with short-term disease evolution in patients with relapsing-remitting (RR) MS. Methods Using a 1.5-T magnetic resonance imaging (MRI) system with a tailored cervical cord phased array coil, fast short-tau inversion recovery (fast-STIR) and MTR scans were obtained from 14 untreated patients with RRMS at baseline. Cervical cord MTR histograms were derived. Over the 18- month follow-up period, relapse rate was measured and disability assessed by the Expanded Disability Status Scale (EDSS) score. Results Average cervical cord MTR was correlated with relapse rate ( r= -0.56, P = 0.037). A moderate correlation ( r values ranging from -0.33 to -0.36) between baseline cervical cord MTR metrics and EDSS changes over 18 months was also noted, albeit statistical significance was not reached ( P = 0.26 and 0.21, respectively) perhaps because of the relatively small sample size. Conclusions This study suggests that a ‘snapshot’ MT MRI assessment of the cervical cord may detect cervical cord tissue changes associated with short-term disease evolution in RRMS.

Measurement of magnetization transfer ratio (MTR) from cervical spinal cord: Multicenter reproducibility and variability

2018 ◽  
Vol 49 (6) ◽  
pp. 1777-1785 ◽  
Author(s):  
Benoit Combès ◽  
Laureline Monteau ◽  
Elise Bannier ◽  
Virginie Callot ◽  
Pierre Labauge ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio

Magnetization Transfer Ratio in Peripheral Nerve Tissue

2018 ◽  
Vol 53 (7) ◽  
pp. 397-402 ◽  
Author(s):  
Jennifer Kollmer ◽  
Thorsten Kästel ◽  
Johann M.E. Jende ◽  
Martin Bendszus ◽  
Sabine Heiland
Keyword(s):  
Peripheral Nerve ◽  
Magnetization Transfer ◽  
Nerve Tissue ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio

Improvement of magnetization transfer ratio in new gadolinium-enhanced lesions detected before and during therapy with interferon-β-1a

2010 ◽  
Author(s):  
Mariko Kita ◽  
Donald E Goodkin ◽  
Peter Bacchetti ◽  
Emmanuelle Waubant ◽  
Sarah J Nelson ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Interferon Β ◽  
Transfer Ratio

scholarly journals Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis

2020 ◽  
Vol 7 (5) ◽  
pp. 799-807 ◽  
Author(s):  
Jennifer Kollmer ◽  
Ute Hegenbart ◽  
Christoph Kimmich ◽  
Ernst Hund ◽  
Jan C. Purrucker ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transthyretin Amyloidosis ◽  
Transfer Ratio ◽  
Hereditary Transthyretin Amyloidosis

Brain atrophy and magnetization transfer ratio following methylprednisolone in multiple sclerosis: short-term changes and long-term implications

2005 ◽  
Vol 11 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Robert J Fox ◽  
Elizabeth Fisher ◽  
Jean Tkach ◽  
Jar-Chi Lee ◽  
Jeffrey A Cohen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Whole Brain ◽  
Transfer Ratio ◽  
Short Term Change ◽  
Term Change ◽  
The Impact

Background: The short-term effect of corticosteroids on MRI measures of multiple sclerosis (MS) is not well understood and may have a significant impact when using these quantitative measures to evaluate disease activity and changes following other therapeutic interventions. Objective: To determine the impact of a course of intravenous methylprednisolone (IVMP) on quantitative measures of disease activity and tissue injury in MS patients. Methods: We prospectively measured brain parenchymal fraction (BPF), magnetization transfer ratio (MTR, lesional and whole brain), and lesion volumes on nine weekly brain MRI studies in ten MS patients receiving a course of IVMP. A group of nine MS patients not receiving IVMP served as controls. Results: In comparison to untreated controls, BPF declined over the eight weeks following IVMP treatment (P<0.02). BPF decline was most prominent in patients with secondary progressive MS (SPMS, P<0.03), and was not seen in relapsing-remitting (RR) MS patients. Short-term change in BPF correlated with baseline BPF (r=0.62, P=0.05) and short-term change in lesional MTR (r=-0.55, P=0.03), but not with change in enhancing lesion volume. Short-term change in lesional MTR inversely correlated with baseline lesional and whole brain MTR (r=-0.79, P=0.04 for both). There was no significant difference between treated and control patients in measures of MTR or T2, T1 or enhancing lesion volumes. Conclusions: Patients with SPMS showed a greater decline in BPF following IVMP than RRMS patients. A correlation between changes in BPF and MTR suggest that these changes are secondary to altered water content within MS lesions. Differential response to a standardized therapeutic intervention in RRMS and SPMS suggests that responses to therapy may differ due to a fundamental pathologic difference between early and late stage MS.

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