68Ga-DOTA-TOC uptake in neuroendocrine tumour and healthy tissue: differentiation of physiological uptake and pathological processes in PET/CT

2013 ◽  
Vol 40 (4) ◽  
pp. 514-523 ◽  
Author(s):  
A. Kroiss ◽  
D. Putzer ◽  
C. Decristoforo ◽  
C. Uprimny ◽  
B. Warwitz ◽  
...  
Keyword(s):  
Neuroendocrine Tumour ◽  
Tissue Differentiation ◽  
Healthy Tissue ◽  
Physiological Uptake ◽  
Pet Ct

scholarly journals A [68Ga]Ga-DOTANOC PET/CT Radiomic Model for Non-Invasive Prediction of Tumour Grade in Pancreatic Neuroendocrine Tumours

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 870
Author(s):  
Alessandro Bevilacqua ◽  
Diletta Calabrò ◽  
Silvia Malavasi ◽  
Claudio Ricci ◽  
Riccardo Casadei ◽  
...  
Keyword(s):  
Neuroendocrine Tumour ◽  
Area Under The Curve ◽  
Tumour Volume ◽  
Assessment Method ◽  
Second Order ◽  
Tumour Grade ◽  
Non Invasive ◽  
Pet Ct ◽  
Median Test ◽  
Fdg Pet Ct

Predicting grade 1 (G1) and 2 (G2) primary pancreatic neuroendocrine tumour (panNET) is crucial to foresee panNET clinical behaviour. Fifty-one patients with G1-G2 primary panNET demonstrated by pre-surgical [68Ga]Ga-DOTANOC PET/CT and diagnostic conventional imaging were grouped according to the tumour grade assessment method: histology on the whole excised primary lesion (HS) or biopsy (BS). First-order and second-order radiomic features (RFs) were computed from SUV maps for the whole tumour volume on HS. The RFs showing the lowest p-values and the highest area under the curve (AUC) were selected. Three radiomic models were assessed: A (trained on HS, validated on BS), B (trained on BS, validated on HS), and C (using the cross-validation on the whole dataset). The second-order normalized homogeneity and entropy was the most effective RFs couple predicting G2 and G1. The best performance was achieved by model A (test AUC = 0.90, sensitivity = 0.88, specificity = 0.89), followed by model C (median test AUC = 0.87, sensitivity = 0.83, specificity = 0.82). Model B performed worse. Using HS to train a radiomic model leads to the best prediction, although a “hybrid” (HS+BS) population performs better than biopsy-only. The non-invasive prediction of panNET grading may be especially useful in lesions not amenable to biopsy while [68Ga]Ga-DOTANOC heterogeneity might recommend FDG PET/CT.

scholarly journals 68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake

2014 ◽  
Vol 42 (3) ◽  
pp. 531-532 ◽  
Author(s):  
Yaping Luo ◽  
Miao Yu ◽  
QingQing Pan ◽  
Wenming Wu ◽  
Taiping Zhang ◽  
...  
Keyword(s):  
Physiological Uptake ◽  
Pet Ct

Physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging

2018 ◽  
Vol 59 (12) ◽  
pp. 1487-1493 ◽  
Author(s):  
Guohua Shen ◽  
Meng Liang ◽  
Minggang Su ◽  
Anren Kuang
Keyword(s):  
Bone Marrow ◽  
Vertebral Body ◽  
Cervical Vertebrae ◽  
Healthy Adults ◽  
Physiological Uptake ◽  
Vertebral Bone ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Vertebral Bone Marrow ◽  
18F Fdg

Background 18F-fluorodeoxyglucose *Equal contributors. positron emission tomography/computed tomography (18F-FDG PET/CT) has proven to be a valuable imaging modality for the assessment of bone marrow condition. Purpose To investigate the physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging, and correlate the appearance with clinical factors including gender, body mass index, and age. Material and Methods A total of 64 healthy individuals underwent PET/CT scan, and for each vertebral body, the mean and maximum standardized uptake value (SUVmean and SUVmax) were determined in the central slice of vertebral body on the transversal fused PET/CT image. For each individual, the FDG uptake of the four regions was obtained by averaging the SUVmean and SUVmax of the vertebrae in individual regions. Results The FDG uptake from thoracic to sacral vertebrae showed an upward trend first, then a downward trend, while that of cervical vertebrae was relatively stable. The SUVmax and SUVmean values of bone marrow in the old group (age ≥ 50 years) were significantly lower than those in the young group (age < 50 years) in all regions of the spine ( P < 0.05). FDG uptake of the whole spine showed significant negative correlation with age, and the strongest correlation was observed in lumbar spine (SUVmean: r = −0.364, P < 0.05; SUVmax: r = −0.344, P < 0.05). Conclusion FDG uptake showed a tendency to increase first then decrease from thoracic to sacral vertebrae while the tendency was not obvious in cervical vertebrae. In addition, the glycolytic metabolism of all the four regions decreased with advancing age.

Radiation exposure of patients during 68Ga-DOTATOC PET/CT examinations

2009 ◽  
Vol 48 (05) ◽  
pp. 201-207 ◽  
Author(s):  
K. Zöphel ◽  
R. Freudenberg ◽  
L. Oehme ◽  
M. Andreeff ◽  
G. Wunderlich ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Radiation Exposure ◽  
Somatostatin Receptor ◽  
Blood Pool ◽  
Biological Data ◽  
Whole Body ◽  
Physiological Uptake ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Routine Clinical Setting

Summary Aim: Investigation of the biodistribution and calculation of dosimetry of Ga-68-DOTATOCfor patients imaged in the routine clinical setting for diagnosis or exclusion of neuroendocrine tumours. Patients, methods: Dynamic PET/CT-imaging (Biograph 16) was performed over 20 min in 14 patients (8 men, 6 women) after injection of (112 ± 22) MBq 68Ga-DOTATOC followed by whole body 3D-acquisition (8 bed positions, 3 or 4 min each) 30 min p.i. and 120 min p.i. Urinary tracer elimination was measured and blood activity was derived non-invasively from the blood pool of the heart. The relevant organs for dosimetry were spleen, kidneys, liver, adrenals, urinary bladder and pituitary gland. Dosimetry was performed using OLINDA/ EXM 1.0 software and specific organ uptake was expressed as standardized uptake values (SUVs). Results: Rapid physiological uptake of the radiotracer could be demonstrated in liver, spleen and kidneys, adrenals and pituitary gland (mean SUVs were 6, 20, 16, 10, and 4, respectively). Radiotracer elimination was exclusively via urine (16% of injected dose within 2h); no redistribution could be observed. The spleen and the kidneys received the highest radiation exposure (0.24 mSv/MBq, 0.22 mSv/MBq resp.), mean effective dose yielded 0.023 mSv/MBq. Conclusion: 68Ga-DOTATOC is used extensively for diagnosis of somatostatin receptor positive tumours because it has several advantages over the 111In-labelled ligand. The derived dosimetric values are lower than first approximations from the biological data of OctreoScan. The use of CT for transmission correction of the PET data delivers radiation exposure up to 1 mSv (low dose).

scholarly journals PET/CT analysis of 21 patients with breast cancer: physiological distribution of 18F-choline and diagnostic pitfalls

2018 ◽  
Vol 46 (8) ◽  
pp. 3138-3148 ◽  
Author(s):  
Fathinul Fikri Ahmad Saad ◽  
Mohd Hazeman Zakaria ◽  
Bahunu Appanna
Keyword(s):  
Breast Cancer ◽  
Premenopausal Women ◽  
Axial Skeleton ◽  
Left Breast ◽  
Whole Body ◽  
Appendicular Skeleton ◽  
Choline Uptake ◽  
Physiological Uptake ◽  
Positron Emission ◽  
Pet Ct

Objectives 18F-choline is a useful tracer for detecting tumours with high lipogenesis. Knowledge of its biodistribution pattern is essential to recognise physiological variants. The aim of this study was to describe the physiologic distribution of 18F-choline and pitfalls in patients with breast cancer. Methods Twenty-one consecutive patients with breast cancer (10 premenopausal and 11 postmenopausal women; mean age, 52.82 ± 10.71 years) underwent 18F-choline positron emission tomography (PET)/computed tomography (CT) for staging. Whole-body PET/CT was acquired after 40 minutes of 18F-choline uptake. Acquired PET images were measured semiquantitatively. Results All patients showed pitfalls unrelated to breast cancer. These findings were predominantly caused by physiological glandular uptake in the liver, spleen, pancreas, bowels, axial skeleton (85%-100%), inflammation and benign changes (4.76%), appendicular skeleton (4.76%–19.049%), and site contamination (61.9%). In <1%, a concomitant metastatic neoplasm was found. The breast showed higher physiological uptake in premenopausal compared with postmenopausal woman (18F-choline maximum standardised uptake values [g/dL] of the right breast = 2.04 ± 0.404 vs 1.59 ± 0.97 and left breast = 2.00 ± 0.56 vs 1.93 ± 1.28, respectively). Conclusion 18F-choline uptake was higher in premenopausal women. Physiological 18F-choline uptake was observed in many sites, representing possible pathologies.

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