Diffusion-weighted and hepatobiliary phase gadoxetic acid-enhanced quantitative MR imaging for identification of complete pathologic response in colorectal liver metastases after preoperative chemotherapy

2015 ◽  
Vol 41 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Hooman Hosseini-Nik ◽  
Sandra E. Fischer ◽  
Carol-Anne E. Moulton ◽  
Gautam Karbhase ◽  
Ravi J. Menezes ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastases ◽  
Pathologic Response ◽  
Gadoxetic Acid ◽  
Hepatobiliary Phase ◽  
Complete Pathologic Response ◽  
Quantitative Mr Imaging ◽  
Quantitative Mr

Complete Pathologic Response After Preoperative Chemotherapy for Colorectal Liver Metastases: Myth or Reality?

2008 ◽  
Vol 26 (10) ◽  
pp. 1635-1641 ◽  
Author(s):  
René Adam ◽  
Dennis A. Wicherts ◽  
Robbert J. de Haas ◽  
Thomas Aloia ◽  
Francis Lévi ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Predictive Factors ◽  
Colorectal Liver Metastases ◽  
Objective Response ◽  
Survival Rates ◽  
Postoperative Mortality ◽  
Pathologic Response ◽  
High Survival ◽  
Complete Pathologic Response

Purpose Complete clinical response (CCR) of colorectal liver metastases (CLM) following chemotherapy is of limited predictive value for complete pathologic response (CPR) and cure of the disease. The objective of this study was to determine predictive factors of CPR as well as its impact on survival. Patients and Methods From January 1985 to July 2006, 767 consecutive patients with CLM underwent liver resection after systemic chemotherapy. Patients with CPR were compared with patients without CPR. Results Twenty-nine of 767 (4%) patients had CPR, and none of these 29 patients had CCR. Patients with CPR (mean age, 54 years) had a mean number of 3.3 metastases at diagnosis (mean size, 29.3 mm). Objective response and stable disease were observed in 79% and 21% of cases, respectively. Postoperative mortality rate was 0%. After a median follow-up of 52.2 months (range, 1.1 to 193.0 months), overall 5-year survival was 76% for patients with CPR compared with 45% for patients without CPR (P = .004). Independent predictive factors for CPR were: age ≤ 60 years, size of metastases ≤ 3 cm at diagnosis, carcinoembryonic antigen (CEA) level at diagnosis ≤ 30 ng/mL, and objective response following chemotherapy. The probability of CPR ranged from 0.2% when all factors were absent to 30.9% when all were present. Conclusion CPR was observed in 4% of patients with CLM treated with preoperative chemotherapy. However, CPR may occur in almost one-third of objective responders age ≤ 60 years with metastases ≤ 3 cm and low CEA values. CPR is associated with uncommon high survival rates.

Chemotherapy-Induced Normalization of FDG Uptake by Colorectal Liver Metastases Does Not Usually Indicate Complete Pathologic Response

2007 ◽  
Vol 11 (9) ◽  
pp. 1112-1119 ◽  
Author(s):  
Marcus C. B. Tan ◽  
David C. Linehan ◽  
William G. Hawkins ◽  
Barry A. Siegel ◽  
Steven M. Strasberg
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Pathologic Response ◽  
Complete Pathologic Response ◽  
Fdg Uptake

scholarly journals Two-stage hepatectomy for colorectal liver metastases: Pathologic response to preoperative chemotherapy is associated with second-stage completion and longer survival

Surgery ◽  
2019 ◽  
Vol 165 (4) ◽  
pp. 703-711 ◽  
Author(s):  
François Quénet ◽  
Marie-Hélène Pissas ◽  
Hugo Gil ◽  
Lise Roca ◽  
Sébastien Carrère ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastases ◽  
Pathologic Response ◽  
Two Stage ◽  
Second Stage

The target sign in colorectal liver metastases: an atypical Gd-EOB-DTPA “uptake” on the hepatobiliary phase of MR imaging

2015 ◽  
Vol 40 (7) ◽  
pp. 2364-2371 ◽  
Author(s):  
Vincenza Granata ◽  
Orlando Catalano ◽  
Roberta Fusco ◽  
Fabiana Tatangelo ◽  
Daniela Rega ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Hepatobiliary Phase ◽  
Target Sign

scholarly journals Impact of homogeneous pathologic response to preoperative chemotherapy in patients with multiple colorectal liver metastases

2017 ◽  
Vol 23 (45) ◽  
pp. 8027-8034
Author(s):  
Charles Sabbagh ◽  
Denis Chatelain ◽  
Christophe Attencourt ◽  
Jean-Paul Joly ◽  
Bruno Chauffert ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Preoperative Chemotherapy ◽  
Colorectal Liver Metastases ◽  
Pathologic Response
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